Abstract: A method of reducing or preventing the occurrence of respiratory infections, and other ailments associated with close quartering of non-human mammals such as cattle, the ailments generally referred to as “shipping fever.” The methods may comprise administering xylitol, possibly in the form a water or saline based solution, to the non-human mammals in a mist form. The mist may be applied directly to the nostrils of the animal, or may be applied in the general vicinity of the animal, such that the solution is inhaled.