Abstract: A method utilizing compositions for topical application which are adapted for the prevention and treatment of viral infections such as Herpes, AIDS and other envelope virus infections are disclosed. The compositions of the present invention produce a synergistic anti-viral effect when used in combination. The formulation contains a humectant such as sorbitol, glycerol, or other comparable compound in the range of 20-80% w/v final concentration, which facilitates structural and/or functional three dimensional disruption or disorientation of the viral envelope. The activation of the destruction of the envelope and subsequent death of the envelope virus is then achieved using combination of inorganic monovalent anions, nonionic detergents and anionic detergents. These monovalent anions can include sodium bicarbonate, sodium thiocyanate, sodium fluoride and sodium chloride at about 0.5 to 5% w/v final concentration; nonionic detergents such as Tween 20 at concentrations of about 0.

Abstract: The present invention provides compositions for the lysis and killing of microbes in general, and in particular provides oral compositions for the lysis and killing oral bacteria. The compositions of the present invention include a humectant such as glycerol, sorbitol or comparable compounds and provide an in-mouth concentration of such substances from about 20% to about 80% weight/volume in dentifrice preparations, in particular mouthrinses. These compositions further comprises (a) bicarbonate ion at about 0.5% to about 2% wt./vol. and if desired, thiocyanate, chloride or fluoride ion at about 0.5% to about 2% wt./vol. (b) sodium lauroyl sarcosinate or other anionic detergents from about 0.05% to about 1% wt./vol. and (c) Tween 20 or other non-ionic detergents or structurally similar compounds from about 0.01% to about 3% vol./vol. In addition, alcohol may be added up to a level of 15% vol./vol. along with appropriate sweetening and flavoring agents. Water is then added to 100%.

Abstract: A composition for reducing the transmissability of viral infection from a subject infected therewith which comprises a topically applicable, pharmaceutically acceptable carrier and a viricidally effective amount of a polypeptide of between 24 and 500 aminoacid residues comprising at least 24 residues of L-Histidine.

Abstract: Dental compositions containing bicarbonate anion in combination with a monovalent anion such as fluoride, chloride or thiocyanate and methods of using them in anti-carogenic, antiplaque and antiperiodontopathic therapy are disclosed herein.

Abstract: Polypeptides containing a substantial proportion of L-histidine are effective fungicidal agents. They are particularly effective against C. albicans and have a high degree of safety and nontoxicity because of their structural similarity to naturally occuring histidine-rich polypeptides which are unique to the salivas of humans and old world monkeys.

Abstract: Dental compositions containing bicarbonate anion in combination with a monovalent anion such as fluoride, chloride or thiocyanate and methods of using them in anti-caries therapy are disclosed herein.