Abstract: Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.

Abstract: Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.

Abstract: A mixture, apparatus, and method is provided for formulating, solidifying, packaging, shipping, and reprocessing laundry active for purposes of providing laundry active product to developing markets.

Abstract: The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin comprising the steps of introducing a plasmid containing a DNA encoding antibiotic resistance into a Bordetella bronchiseptica strain, selecting for isolates in which the DNA encoding antibiotic resistance is recombinantly incorporated into the chromosome in place of the Bordetella bronchiseptica toxin gene, introducing a plasmid containing DNA encoding subunits of the Bordetella pertussis toxins into the Bordetella bronchiseptica isolates; and, selecting for isolates in which DNA encoding Bordetella pertussis toxin subunit is recombinantly incorporated into the chromosome, the resulting cells producing the Bordetella pertussis toxin.

Abstract: A support or jack that hangs from the tabs of a poured concrete wall. The support may include a hook that engages in an opening in the tab, to connect the support to the wall. The support may include a slot in which the tab is received, to connect the support to the wall.

Abstract: A weight training machine includes a main frame, a lever carriage mechanism, an adjustment linkage and a stop mechanism. A lever carriage mechanism is pivotally connected to the main frame. The lever carriage mechanism includes a weight carrying portion adapted to carry at least one weight. An input mechanism is connected to the lever carriage mechanism. The adjustment linkage is connected between the lever carriage mechanism and the main frame and is configured to selectively adjust an arc of rotation of the weight carrying portion of the lever carriage mechanism about the main frame such that the weight carrying portion may selectively traverse each of a plurality of predefined strength curves in response to movement of the input mechanism by a user.

Abstract: An attachment extends between an outer sleeve and an inner riser pipe where the pipe penetrates the keel of a platform. In one version, the attachment is a conically-shaped with a small diameter ring that engages the riser pipe and a large diameter ring that engages the outer sleeve. This attachment has elements that are very flexible in bending but relatively stiff and strong in axial load. Other versions include flat rings where lateral load is taken directly into tension and compression in the beams, allowing for relatively high lateral load transfer. Both the conically-shaped attachment and the flat ring have a number of variations that provide low bending stiffness but high axial stiffness of the elements. Depending on whether resistance to axial loads, lateral loads, or resistance to combination of both loads is desired, the attachment and the flat ring may be used alone or in combination.

Abstract: A pager receiver based system provides a method and an apparatus for receiving and detecting a tornado alert or other severe weather alert from the National Weather Service, determining the region or grid block to which the alert applies, and broadcasting an alert signal to a plurality of pager receivers, all programmed with the same sub-address, within that region or grid block.

Abstract: An internal tieback connector for connecting a riser from a platform to a subsea wellhead having internal grooves and a casing hanger therein. The connector has an inner body which carries a lower housing adapted to land on the wellhead. A plurality of dogs abut the lower housing and are adapted to engage and lift the inner body relative to the lower housing. An upper housing is carried on the inner body and adapted to force the dogs inward into engagement with the inner body. A plurality of latch members are carried on the inner body and are adapted to engage the internal grooves when the internal is moved upward relative to the lower housing.

Abstract: A pager receiver based system provides a method and an apparatus for receiving and detecting a tornado alert from the National Weather Service, determining the region to which the alert applies, and broadcasting an alert signal to a plurality of pager receivers, all programmed with the same pager number, within that region.

Abstract: A repair kit for a sliding glass patio door having worn original wheel assemblies includes an edge bracket with an associated edge wheel for installation on a leading edge of the door and a side bracket with an associated side wheel for installation on a side of the door near a trailing edge. The edge wheel and the side wheel support the weight of the door, while the worn original wheel assemblies are left in place for guiding the door. An original track for the door provides a guideway on which the door and the original wheel assemblies travel. The edge bracket includes an edge plate that can be fastened to the leading edge, and a frame is attached to the edge plate. An axle is mounted in the frame, and the edge wheel is mounted on the axle. The side bracket has a side plate and a frame. The frame has legs mounted parallel to the side plate for holding an axle perpendicular to the side plate. The side wheel is mounted on the axle located within the frame on the side plate.