Patents by Inventor Jerry L. Atwood
Jerry L. Atwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9908874Abstract: The present invention provides a method for physically separating the active pharmaceutical ingredient (API) from the excipients in a pharmaceutical formulation before the API is fully characterized by standard techniques. The presently disclosed method is based on making use of the difference in density of the API and that of the excipients. In the method, the API is not dissolved, nor is the crystal form of the API changed.Type: GrantFiled: April 25, 2016Date of Patent: March 6, 2018Assignee: The Curators of the University of MissouriInventor: Jerry L. Atwood
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Publication number: 20160340350Abstract: The present invention provides a method for physically separating the active pharmaceutical ingredient (API) from the excipients in a pharmaceutical formulation before the API is fully characterized by standard techniques. The presently disclosed method is based on making use of the difference in density of the API and that of the excipients. In the method, the API is not dissolved, nor is the crystal form of the API changed.Type: ApplicationFiled: April 25, 2016Publication date: November 24, 2016Applicant: The Curators of the University of MissouriInventor: Jerry L. Atwood
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Publication number: 20140336196Abstract: The present invention relates to novel phosphoric acid salts of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine, and polymorphs, hydrates and solvates thereof, which are potent inhibitors of dipeptidyl peptidase-IV useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The present invention also relates to the process for preparing the novel phosphoric acid salts of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine, as well as pharmaceutical compositions containing the novel phosphoric acid salts, and methods of use thereof for the treatment of diabetes, obesity, and high blood pressure.Type: ApplicationFiled: May 22, 2012Publication date: November 13, 2014Applicant: Merck Sharp & Dohme Corp.Inventor: Jerry L. Atwood
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Patent number: 8252954Abstract: A method for the preparation of calix[n]arene derivatives, in particular phosphonated calix[n]arenes. The present invention also relates to nano-structures of phosphonated calix[n]arenes.Type: GrantFiled: June 6, 2008Date of Patent: August 28, 2012Assignees: The Curators of The University of Missouri, The University of Western AustraliaInventors: Colin L. Raston, Mohamed Makha, Thomas Edward Clark, Jerry L. Atwood
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Patent number: 8172924Abstract: A method of using a crystallographic framework of sterically bulky calixarene molecules to selectively separate and/or store volatile gas components. Sterically bulky calix[4]arenes or their derivatives form a crystalline lattice that has relatively large lattice voids, is nonporous, and is held together predominately by van der Weals forces. The calix[4]arene lattice can form a guest-host assembly by absorbing a desired volatile gas guest component into the crystalline lattice without any phase shift or other change to the lattice structure. The crystalline calixarene can also be desirably used to purify a gas mixture by removing one or more volatile gas contaminants or by removing and storing the desired volatile gas component. This method can preferably be used to purify a hydrogen gas stream by removing the carbon dioxide and carbon monoxide contaminants or to remove and store oxygen from the air or carbon dioxide and carbon monoxide from combustion gases.Type: GrantFiled: April 18, 2005Date of Patent: May 8, 2012Inventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga
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Publication number: 20120036999Abstract: A method of using a crystallographic framework of sterically bulky calixarene molecules to selectively separate and/or store volatile gas components. Sterically bulky calix[4]arenes or their derivatives form a crystalline lattice that has relatively large lattice voids, is nonporous, and is held together predominately by van der Waals forces. The calix[4]arene lattice can form a guest-host assembly by absorbing a desired volatile gas guest component into the crystalline lattice without any phase shift or other change to the lattice structure. The crystalline calixarene can also be desirably used to purify a gas mixture by removing one or more volatile gas contaminants or by removing and storing the desired volatile gas component. This method can preferably be used to purify a hydrogen gas stream by removing the carbon dioxide and carbon monoxide contaminants or to remove and store oxygen from the air or carbon dioxide and carbon monoxide from combustion gases.Type: ApplicationFiled: April 18, 2005Publication date: February 16, 2012Inventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga
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Publication number: 20100185022Abstract: A method for the preparation of calix[n]arene derivatives, in particular phosphonated calix[n]arenes. The present invention also relates to nano-structures of phosphonated calix[n]arenes.Type: ApplicationFiled: June 6, 2008Publication date: July 22, 2010Inventors: Colin L. Raston, Mohamed Makha, Thomas Edward Clark, Jerry L. Atwood
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Patent number: 7217846Abstract: A guest host assembly comprising a host assembly formed of calixarene molecules and a guest component located within the host assembly. A crystallographic assembly of layers of the calixarene molecules and stacked along the crystallographic c axis of the assembly in a repeating configuration associated together predominantly by van der Waal forces. The guest component is transferable through the host assembly in a direction normal to the stacked layers. The calixarene molecules are configured in bilayers of adjacent layers along the c axis. The bilayers are shifted along the a or b axis so the assembly, relative to a corresponding assembly of the calixarene molecules without the inclusion of the guest component is shifted. The calixarene are calix(N)arenes in which N is an integer within the range of 4–8. The calixarene molecules are distally substituted with a substituent such as methyl, ethyl, propyl, butyl amyl or phenyl groups.Type: GrantFiled: October 31, 2002Date of Patent: May 15, 2007Inventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga
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Patent number: 7169957Abstract: Disclosed are the general principles upon which closed molecular or ionic structural frameworks may be prepared. These frameworks are based upon the self-assembly (wherein the term self-assembly refers to the association of chemical components through inter-component bonds) of n>4 subunits where surface curvature is supplied by edge sharing of subunits.Type: GrantFiled: April 7, 2003Date of Patent: January 30, 2007Inventors: Jerry L. Atwood, Leonard R. MacGillivray
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Self-assembled calixarene-based guest-host assemblies for guest storage by van der Waals confinement
Patent number: 7132571Abstract: A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dilated channels having void volumes within the range of 100-200 ?3. A guest component, such as hydrogen, methane, or another hydrocarbon or halocarbon, is encapsulated within the dilated channels of the spheroidal host assembly and retained within the channels primarily by van der Waals forces. The guest-host assembly is stable at a temperature of 150° C. or higher. The temperature at which the onset of the release of the guest component occurs is within the range of 150-300° C.Type: GrantFiled: May 9, 2002Date of Patent: November 7, 2006Assignee: The Curators of the University of MissouriInventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga -
Patent number: 7014868Abstract: A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host assembly. A guest component, specifically a pharmaceutically active agent, is encapsulated within the spheroidal host assembly to provide a guest/host assembly exhibiting a high stability, being stable upon a solubilization in a mixture of acetone and water in a one-to-one ratio for a period of one day at a temperature of 37° C. The pharmaceutically active agent encapsulated within the spheroidal hexamer is selected from the group consisting of Depakote, Wellbutrin, Allegra, Neurontin, Zovirax, and Claritin. A process for the preparation of a hexameric complex, as described above, from a methylene-bridged tetramer solubilized in an amphiphilic organic solvent. An activator is incorporated into the amphiphilic solvent containing the tetramer.Type: GrantFiled: October 16, 2001Date of Patent: March 21, 2006Assignee: Curators of the University of MissouriInventor: Jerry L. Atwood
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Publication number: 20040087666Abstract: A guest host assembly comprising a host assembly formed of calixarene molecules and a guest component located within the host assembly. A crystallographic assembly of layers of the calixarene molecules and stacked along the crystallographic c axis of the assembly in a repeating configuration associated together predominantly by van der Waal forces. The guest component is transferable through the host assembly in a direction normal to the stacked layers. The calixarene molecules are configured in bilayers of adjacent layers along the c axis. The bilayers are shifted along the a or b axis so the assembly, relative to a corresponding assembly of the calixarene molecules without the inclusion of the guest component is shifted. The calixarene are calix(N)arenes in which N is an integer within the range of 4-8. The calixarene molecules are distally substituted with a substituent such as methyl, ethyl, propyl, butyl amyl or phenyl groups.Type: ApplicationFiled: October 31, 2002Publication date: May 6, 2004Inventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga
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Publication number: 20040014963Abstract: Disclosed are the general principles upon which closed molecular or ionic structural frameworks may be prepared. These frameworks are based upon the self-assembly (wherein the term self-assembly refers to the association of chemical components through inter-component bonds) of n>4 subunits where surface curvature is supplied by edge sharing of subunits.Type: ApplicationFiled: April 7, 2003Publication date: January 22, 2004Inventors: Jerry L. Atwood, Leonard R. MacGillivray
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Self-assembled calixarene-based guest-host assemblies for guest storage by van der waals confinement
Publication number: 20030212301Abstract: A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dilated channels having void volumes within the range of 100-200 Å3. A guest component, such as hydrogen, methane, or another hydrocarbon or halocarbon, is encapsulated within the dilated channels of the spheroidal host assembly and retained within the channels primarily by van der Waals forces. The guest-host assembly is stable at a temperature of 150° C. or higher. The temperature at which the onset of the release of the guest component occurs is within the range of 150-300° C.Type: ApplicationFiled: May 9, 2002Publication date: November 13, 2003Inventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga -
Publication number: 20030073872Abstract: A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host assembly. A guest component, specifically a pharmaceutically active agent, is encapsulated within the spheroidal host assembly to provide a guest/host assembly exhibiting a high stability, being stable upon a solubilization in a mixture of acetone and water in a one-to-one ratio for a period of one day at a temperature of 37° C. The pharmaceutically active agent encapsulated within the spheroidal hexamer is selected from the group consisting of Depakote, Wellbutrin, Allegra, Neurontin, Zovirax, and Claritin. A process for the preparation of a hexameric complex, as described above, from a methylene-bridged tetramer solubilized in an amphiphilic organic solvent. An activator is incorporated into the amphiphilic solvent containing the tetramer.Type: ApplicationFiled: October 16, 2001Publication date: April 17, 2003Inventor: Jerry L. Atwood
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Patent number: 6495669Abstract: Amphiphilic, polyhedron-shaped p-sulfonatocalix[4]arene building blocks, which have been shown previously to assemble into bilayers in an antiparallel fashion, assemble in a parallel alignment into spherical and helical tubular structures on the addition of pyridine N-oxide and lanthanide ions. The addition of greater amounts of pyridine N-oxide changed the curvature of the assembling surface and led to the formation of extended tubules. The inventive compositions and methods are useful for drug delivery and construction of nano-devices.Type: GrantFiled: August 11, 2000Date of Patent: December 17, 2002Assignee: The Curators of the University of MissouriInventors: Jerry L. Atwood, G. William Orr, Leonard J. Barbour
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Patent number: 5711927Abstract: This invention relates to a method of purifying afullerenes by recrystallization of a fullerene-complexing agent complex and to a fullerene-complexing agent complex.Type: GrantFiled: March 27, 1995Date of Patent: January 27, 1998Inventors: Jerry L. Atwood, Colin L. Raston
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Patent number: 5489612Abstract: Calixarene derivatives, their synthesis and use as chloride channel blockers are described. Preferred calixarene derivatives are of the formula: ##STR1## wherein R is an acidic group or salt thereof, such as SO.sub.3 X or R.sup.1 SO.sub.3 X where X is H or Na, and R.sup.1 is ##STR2## where m=1-2, and R.sup.3 and R.sup.4 the same or different is each H or a C.sub.1-4 alkyl, or a nitrogen-containing group of the formula ##STR3## or A, wherein R.sup.5 is a C.sub.1-4 alkyl, R.sup.6 is a C.sub.1-4 alkyl and A is ##STR4## where R.sup.7 and R.sup.8, the same or different each is H or a C.sub.1-4 alkyl, and R.sup.9 and R.sup.10, the same or different, each is H or a C.sub.1-4 alkyl; R' is H or a C.sub.1-4 alkyl; and n is an integer of 4-8, preferably 4, 6 or 8.Type: GrantFiled: January 7, 1994Date of Patent: February 6, 1996Assignee: The University of Alabama at Birmingham Research FoundationInventors: Jerry L. Atwood, Robert J. Bridges, Ravindra K. Juneja, Ashvani K. Singh
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Patent number: 4496744Abstract: A liquid clathrate of a multidentate macromolecular compound complex salt of the formula:[M(multidentate macromolecular compound).sub.m ].sub.x [Al.sub.n R.sub.3n X].sub.y.pZwherein M is a mono-, di, or trivalent cation, R is a lower alkyl group of 1 to 8 carbon atoms, X is a monovalent, divalent or trivalent anion, n is an integer of 2 to 4, x and y are integers from 1 to 3 and m is 1 to 2, Z is an aromatic hydrocarbon compound and p is an integer from 1 to 40. The present liquid clathrate is useful in separating an aromatic hydrocarbon compound from a non-aromatic hydrocarbon compound as well as from a different aromatic hydrocarbon compound.Type: GrantFiled: February 28, 1980Date of Patent: January 29, 1985Assignee: University of AlabamaInventor: Jerry L. Atwood
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Patent number: 4321127Abstract: The method for the liquefaction of a solid carbonaceous substance whereby the liquefaction takes place as a result of the addition of a liquid clathrate to said substance. The liquid clathrate layer then contains the liquified petroleum oil products which are then separated from the liquid clathrate.Type: GrantFiled: March 5, 1981Date of Patent: March 23, 1982Assignee: University of AlabamaInventor: Jerry L. Atwood