Patents by Inventor Jerry Leroy Adams

Jerry Leroy Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolylaminopyridines as inhibitors of FAK
    Patent number: 9446034
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: September 20, 2016
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Hong Lin, Xin Peng
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20160095841
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 20, 2015
    Publication date: April 7, 2016
    Inventors: Jerry Leroy ADAMS, Thomas H. FAITG, Neil W. JOHNSON, Hong LIN, Xin PENG
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20150265589
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: March 30, 2015
    Publication date: September 24, 2015
    Inventors: Jerry Leroy ADAMS, Thomas H. Faitg, Neil W. Johnson, Hong Lin, Xin Peng
  • Pyrazolylaminopyridines as inhibitors of FAK
    Patent number: 9012479
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: April 21, 2015
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Hong Lin, Xin Peng
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20140155410
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: February 6, 2014
    Publication date: June 5, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Jiri Kasparec, Hong Lin, Mark Mellinger, Xin Peng, Ren Xie
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20140107131
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 17, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Jerry Leroy ADAMS, Thomas H. FAITG, Neil W. JOHNSON, Jiri KASPAREC, Hong LIN, Mark MELLINGER, Xin PENG, Ren XIE
  • Benzene Sulfonamide Thiazole and Oxazole Compounds
    Publication number: 20140080851
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 20, 2014
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: GEORGE ADJABENG, JERRY LEROY ADAMS, SCOTT HOWARD DICKERSON, KEITH HORNBERGER, NEIL W. JOHNSON, KEVIN KUNTZ, KIMBERLY PETROV, JEFFREY M. RALPH, TARA RENAE RHEAULT, GREGORY SCHAAF, JOHN STELLWAGEN, XINRONG TIAN, DAVID E. UEHLING, ALEX G. WATERSON, BRIAN WILSON
  • Benzene Sulfonamide Thiazole And Oxazole Compounds
    Publication number: 20130144055
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: January 31, 2013
    Publication date: June 6, 2013
    Applicant: GlaxoSmithKline LLC
    Inventors: George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Benzene sulfonamide thiazole and oxazole compounds
    Patent number: 8415345
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: April 9, 2013
    Assignee: Glaxo SmithKline LLC
    Inventors: George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Deuterated benzene sulfonamide thiazole compounds
    Patent number: 8389723
    Abstract: Deuterated forms of N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: March 5, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Jerry Leroy Adams, Dashyant Dhanak, Dirk A. Heerding, Calvin O. Manning
  • Deuterated Benzene Sulfonamide Thiazole Compounds
    Publication number: 20130053562
    Abstract: Deuterated forms of N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and pharmaceutical compositions containing the same.
    Type: Application
    Filed: July 26, 2012
    Publication date: February 28, 2013
    Inventors: Jerry Leroy Adams, Dashyant Dhanak, Dirk A. Heerding, Calvin O. Manning
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20110207743
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 27, 2009
    Publication date: August 25, 2011
    Inventors: Jerry Leroy Adams, Thomas H Faitg, Neil W Johnson, Hong Lin
  • ANILINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20100317663
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, Q, Z, r, and p are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with FAK overexpression, including proliferative diseases.
    Type: Application
    Filed: February 19, 2009
    Publication date: December 16, 2010
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Xin Peng
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20100113475
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 27, 2009
    Publication date: May 6, 2010
    Inventors: Jerry Leroy ADAMS, Thomas H. Faitg, Neil W. Johnson, Hong Lin
  • Benzene Sulfonamide Thiazole and Oxazole Compounds
    Publication number: 20090298815
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: May 4, 2009
    Publication date: December 3, 2009
    Inventors: Jerry Leroy Adams, Scott Howard Dickerson, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David Edward Uehling, Alex Gregory Waterson, Brian Wilson
  • Azaindole inhibitors of aurora kinases
    Patent number: 7495102
    Abstract: The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: February 24, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Martha A. Sarpong, Nicholas D. Adams, Jeffrey Michael Axten, Amita M. Chaudhari, Dashyant Dhanak, Toshihiro Hamajima, Kenneth Allen Newlander, Cynthia A. Parrish, Jerry Leroy Adams, Domingos J. Silva, Jun Tang
  • SUBSTITUTED PYRAZOLOPYRIMIDINES
    Publication number: 20090029989
    Abstract: Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: July 8, 2008
    Publication date: January 29, 2009
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva, Catherine C. K. Yuan
  • CHEMICAL COMPOUNDS
    Publication number: 20090012309
    Abstract: Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 8, 2009
    Inventors: Jerry Leroy Adams, Jiri Kasparec, Domingos J. Silva
  • 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20080287466
    Abstract: Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: July 9, 2008
    Publication date: November 20, 2008
    Inventors: Jerry Leroy Adams, Deborah Lynne Bryan, Yanhong Feng, Shinichiro Matsunaga, Yutaka Maeda, Yasushi Miyazaki, Masato Nakano, Jean-Philippe Rocher, Hideyuki Sato, Marcus Semones, Domingos J. Silva, Jun Tang
  • Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases
    Publication number: 20080242667
    Abstract: The present invention provides a compound represented by Formula (I): or a salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein. The present invention also relates to a composition comprising the compound of formula (I) and diluents, carriers, or excipients. Furthermore, the present invention relates to a method of treating a disease of cell proliferation comprising administering to a patient in need thereof a pharmaceutically effective amount of the compound of formula (I) or a salt thereof, or a solvate thereof, or a combination thereof.
    Type: Application
    Filed: August 23, 2006
    Publication date: October 2, 2008
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Jeffrey M. Ralph, Domingos J. Silva