Patents by Inventor Jerry M. Kuner

Jerry M. Kuner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12006504
    Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: June 11, 2024
    Assignees: DSM IP Assets B.V., DOW AgroSciences LLC
    Inventors: Terence A. Walsh, Daniel Gachotte, Ann Owens Merlo, Paul G. Roessler, James George Metz, Scott Bevan, Jerry M. Kuner
  • Publication number: 20220170037
    Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
    Type: Application
    Filed: February 11, 2022
    Publication date: June 2, 2022
    Inventors: Terence A. WALSH, Daniel GACHOTTE, Ann Owens MERLO, Paul G. ROESSLER, James George METZ, Scott BEVAN, Jerry M. KUNER
  • Patent number: 10968437
    Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 6, 2021
    Assignee: DSM IP Assets B.V.
    Inventors: James George Metz, Jerry M. Kuner, David Glen McCaskill, Mendy Louise Foster
  • Publication number: 20190100733
    Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
    Type: Application
    Filed: August 21, 2018
    Publication date: April 4, 2019
    Inventors: James G. METZ, Jerry M. KUNER, David Glen MCCASKILL, Mendy Louise FOSTER
  • Patent number: 10087430
    Abstract: Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: October 2, 2018
    Assignee: DSM IP Assets B.V.
    Inventors: James George Metz, Jerry M. Kuner, David Glen McCaskill, Mendy Louise Foster
  • Publication number: 20160348083
    Abstract: Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor proteins of the PUFA synthase systems, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified microorganisms comprising the same, and methods of making and using the same. Also disclosed are genetically modified microorganisms that have been genetically modified to express a PUFA synthase system for the production of PUFAs, wherein the microorganisms have been modified to express the novel enhancing factor proteins of the PUFA synthase system.
    Type: Application
    Filed: January 28, 2015
    Publication date: December 1, 2016
    Inventors: James George METZ, Jerry M. KUNER, David Glen MCCASKILL, Mendy Louise FOSTER
  • Patent number: 9382521
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: July 5, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: James G. Metz, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20140289904
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Application
    Filed: March 21, 2013
    Publication date: September 25, 2014
    Applicant: DSM IP Assets B.V.
    Inventors: James G. METZ, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20130150599
    Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
    Type: Application
    Filed: May 17, 2011
    Publication date: June 13, 2013
    Inventors: Terence A. Walsh, Ann Owens Merlo, Daniel Gachotte, Paul Gordon Roessler, Scott Bevan, Jerry M. Kuner, James G. Metz
  • Patent number: 8426686
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: April 23, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: James G. Metz, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20110250342
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Application
    Filed: January 18, 2011
    Publication date: October 13, 2011
    Applicant: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7973149
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: July 5, 2011
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7960524
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: June 14, 2011
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7919320
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: April 5, 2011
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7897844
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: March 1, 2011
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7842796
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: November 30, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7816504
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: October 19, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7807442
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: October 5, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay
  • Patent number: 7759548
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: July 20, 2010
    Assignee: Martek Biosciences Corporation
    Inventors: James G. Metz, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20100024050
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 12, 2007
    Publication date: January 28, 2010
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay