Patents by Inventor Jerry R. Colca

Jerry R. Colca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense modulation of mitoNEET expression
    Publication number: 20040132078
    Abstract: Antisense compounds, compositions, and methods are provided for modulating the expression of a family of polypeptides from mitochondrial membranes, which bind insulin sensitizing, antidiabetic thiazolodinediones (mitoNEET). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding mitoNEET. Methods of using these compounds for modulation of mitoNEET expression and for treatment of diseases associated with expression of mitoNEET are provided.
    Type: Application
    Filed: December 5, 2003
    Publication date: July 8, 2004
    Inventor: Jerry R. Colca
  • Method and use
    Patent number: 6573291
    Abstract: The invention relates to a method of antagonizing GLP-1 activity in a mammalian patient, comprising administering to said patient an effective amount of a compound of the general formula I: wherein R1 and R2 independently of each other are C1-4alkyl, R3 is halogen, hydroxy, C1-4-alkoxy or trifluoromethoxy, R4 is hydrogen, hydroxy or C1-4-alkoxy, or a pharmacologically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising a compound of formula I.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: June 3, 2003
    Assignee: Biovitrum AB
    Inventors: Alvar Gronberg, Jerry R. Colca
  • Novel method and use
    Publication number: 20020107277
    Abstract: The invention relates to a method of antagonizing GLP-1 activity in a mammalian patient, comprising administering to said patient an effective amount of a compound of the general formula I: 1
    Type: Application
    Filed: December 3, 2001
    Publication date: August 8, 2002
    Inventors: Alvar Gronberg, Jerry R. Colca
  • Use of insulin sensitizing agents to treat hypertension
    Patent number: 5929101
    Abstract: The present invention provides a method for treatin hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: July 27, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jerry R. Colca
  • Use of insulin sensitizing agents to treat hypertension
    Patent number: 5814670
    Abstract: The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: September 29, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jerry R. Colca
  • 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus
    Patent number: 5723476
    Abstract: The present invention provides some novel 4-hydroxycoumarin-3-carboxamide derivatives and the use of a broad class of 4-hydroxycoumarin-3-carboxamide derivatives for the treatment of a patient suffering from or susceptible to diabetes mellitus.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 3, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Scott D. Larsen, Jerry R. Colca, Peter K. W. Harris, Howard R. Miller, Alice L. Laborde, Rolf F. Kletzien, Heinrich Josef Schostarez
  • Use of insulin sensitizing agents to treat hypertension
    Patent number: 5719188
    Abstract: The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: February 17, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventor: Jerry R. Colca
  • Thiazolidinedione derivatives, production and use thereof
    Patent number: 5441971
    Abstract: A thiazolidinedione compound of the formula ##STR1## wherein X,Q are as defined in the specification. The compounds are used for treating diabetes.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: August 15, 1995
    Assignees: The Upjohn Company, Takeda Chemical Industries, Ltd.
    Inventors: Takashi Sohda, Hitoshi Ikeda, John C. Greenfield, Jerry R. Colca, Edgar N. Petzold
  • Use of insulin sensitizing agents to treat hypertension
    Patent number: 5356913
    Abstract: The present invention provides a method for treating hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: October 18, 1994
    Assignee: The Upjohn Company
    Inventor: Jerry R. Colca