Abstract: The present disclosure provides a duplex or single-stranded siRNA molecule against plasminogen, the siRNA molecule containing modified or unmodified nucleotides and wherein at least one strand of the duplex or the single-stranded siRNA has a sequence that has at least 80% sequence identity to any one of SEQ NOs: 1 to 28. Further provided is a duplex or single-stranded siRNA molecule against plasminogen, the siRNA molecule containing modified or unmodified nucleotides and is between 25 and 35 nucleotides in length. The siRNA molecule may be formulated in a lipid nanoparticle as described herein.

Abstract: A blind rivet includes a hollow rivet body having a longitudinally extending indented groove. The groove may be shaped to impart rivet setting characteristics that may be varied to provide desirable fastening characteristics for joints in a number of industries. The shape of the indentation on the rivet body may be varied to cause a portion of the rivet body to collapse and form a secondary head at a predetermined longitudinal location.

Abstract: A brake-cooling device is provided for a motor vehicle having a wheel with a wheel hub, and a disc brake assembly. The brake-cooling device consists of a first fan blade with blade leaves that move air while the first fan blade is in motion. The first fan blade is secured onto the wheel hub on an outside-facing side of the wheel hub. Because the brake-cooling device is positioned on the outside-facing side of the wheel hub (rather than within the disc brake assembly, for example), the brake-cooling device can be readily removed or replaced as necessary. The present invention is also designed such that the first fan blade can be stacked with additional fan blades or with other wheel accessories without interfering with the operation of the wheel (e.g., some embodiments of the invention does not require the wheel offsets to be changed) or disc brake assembly.

Abstract: A flavored, lubricating solution is applied to a solid medicament by spray, dipping, or otherwise coating the medicament. This liquid coating masks the often objectionable taste of the medicament while lubricating it, and thus significantly improving the ability to swallow the medicament. The improvement to the swallowing process is dramatically enhanced with significant reduction in gag reflex, general un-palatability and inability to move the dosage form completely through the mouth, palate, and esophagus to the stomach without sticking or lodging at any point in the process. The solution is a mixture of viscosity-adhesion-lubricity ingredients which includes polyols and polysaccharides, preservative agents, flavoring agents (to improve the palatability of the solution) and optional dispensing agents.

Abstract: A blind rivet includes a hollow rivet body having a longitudinally extending indented groove. The groove may be shaped to impart rivet setting characteristics that may be varied to provide desirable fastening characteristics for joints in a number of industries. The shape of the indentation on the rivet body may be varied to cause a portion of the rivet body to collapse and form a secondary head at a predetermined longitudinal location.

Abstract: A blind rivet includes a hollow rivet body having a longitudinally extending indented groove. The groove may be shaped to impart rivet setting characteristics that may be varied to provide desirable fastening characteristics for joints in a number of industries. The shape of the indentation on the rivet body may be varied to cause a portion of the rivet body to collapse and form a secondary head at a predetermined longitudinal location.

Abstract: A flavored, lubricating solution is applied to a solid medicament by spray, dipping, or otherwise coating the medicament. This liquid coating masks the often objectionable taste of the medicament while lubricating it, and thus significantly improving the ability to swallow the medicament. The improvement to the swallowing process is dramatically enhanced with significant reduction in gag reflex, general un-palatability and inability to move the dosage form completely through the mouth, palate, and esophagus to the stomach without sticking or lodging at any point in the process. The solution is a mixture of viscosity-adhesion-lubricity ingredients which includes polyols and polysaccharides, preservative agents, flavoring agents (to improve the palatability of the solution) and optional dispensing agents.

Abstract: A multi-grip blind rivet 74 includes a rivet body 82, adapted to receive a portion of a mandrel 76. A plurality of indentations 88 are formed in an outer surface 86 of the rivet body 82 in each of three axially spaced transaxial planes. Each indentation 88 is formed with a work hardened base surface 90 having a convex portion, which is formed with axially spaced first and second transaxial edges 106 and 108 having nonlinear portions. Adjacent indentations 88 are separated by ribs 89. A flared intermediate surface 122 extends between the base surface 90 and the outer surface 86. The rivet 74 is assembled within aligned holes 128 and 130 of workpieces 124 and 126, respectively, where, upon setting of the rivet, the indentations 88 collapse and the outer surface 86 bulges against walls of the holes to retain the workpieces together.

Abstract: A blind rivet includes a hollow rivet body having a longitudinally extending indented groove. The groove may be shaped to impart rivet setting characteristics that may be varied to provide desirable fastening characteristics for joints in a number of industries. The shape of the indentation on the rivet body may be varied to cause a portion of the rivet body to collapse and form a secondary head at a predetermined longitudinal location.

Abstract: A fastener includes an axial shank and a clamping face extending radially from the shank. A plurality of serrations are formed on the clamping face and extend radially from a shank periphery to an outer periphery of the clamping face. The shank periphery is axially displaced away from the clamping face relative to the outer periphery of the clamping face to define a ramped surface.