Patents by Inventor Jerry Shay

Jerry Shay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5707795
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Telomerase activity assays for diagnosing pathogenic infections
    Patent number: 5695932
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
    Type: Grant
    Filed: May 13, 1993
    Date of Patent: December 9, 1997
    Assignees: University of Texas System, The Regents of the University of California
    Inventors: Michael D. West, Jerry Shay, Woodring Wright, Elizabeth H. Blackburn, Michael J. McEachern
  • Methods for cancer diagnosis and prognosis
    Patent number: 5693474
    Abstract: A method for predicting tumor progression and prognosing cancer comprises: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the activity with a standard level of telomerase activity; and (d) correlating a high telomerase activity with an indication of unfavorable prognosis and a low telomerase activity with a favorable prognosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 2, 1997
    Assignee: Board of Regents, University of Texas System
    Inventors: Jerry Shay, Michael David West, Woodring E. Wright
  • Methods for screening for agents which modulate telomere length
    Patent number: 5686245
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 11, 1997
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Methods and reagents for lengthening telomeres
    Patent number: 5686306
    Abstract: Method and compositions for increasing telomere length in normal cells can be used to increase the proliferative capacity of cells and to delay the onset of cellular senescence.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: November 11, 1997
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring E. Wright
  • Telomerase diagnostic methods
    Patent number: 5648215
    Abstract: The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the course of disease progression in a patient.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: July 15, 1997
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring E. Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5645986
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: July 8, 1997
    Assignees: Board of Reagents, The University of Texas System, The Reagents of the University of California, Geron Corporation
    Inventors: Michael D. West, Calvin B. Harley, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Homayoun Vaziri
  • Methods for cancer diagnosis and prognosis
    Patent number: 5639613
    Abstract: A method for predicting tumor progression and prognosing cancer comprises: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the activity with a standard level of telomerase activity; and (d) correlating a high telomerase activity with an indication of unfavorable prognosis and a low telomerase activity with a favorable prognosis.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: June 17, 1997
    Assignee: Board of Regents, University of Texas System
    Inventors: Jerry Shay, Michael David West, Woodring E. Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5489508
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: February 6, 1996
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright