Patents by Inventor Jerry Silver

Jerry Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR INDUCING NEURAL PLASTICITY
    Publication number: 20250255939
    Abstract: A method of promoting compensatory plasticity of spared neural cells after a neural injury includes contacting the spared neural cells with an effective amount of a therapeutic agent comprising a therapeutic peptide, wherein the therapeutic peptide comprises an amino acid sequence with at least 70% identity to SEQ ID NO:32.
    Type: Application
    Filed: October 31, 2024
    Publication date: August 14, 2025
    Inventors: Jerry Silver, Yu Luo, Fucheng Luo
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 12171834
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: December 24, 2024
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Methods and compositions for inducing neural plasticity
    Patent number: 12138300
    Abstract: A method of promoting compensatory plasticity of spared neural cells after a neural injury includes contacting the spared neural cells with an effective amount of a therapeutic agent comprising a therapeutic peptide, wherein the therapeutic peptide comprises an amino acid sequence with at least 70% identity to SEQ ID NO:32.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: November 12, 2024
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jerry Silver, Yu Luo, Fucheng Luo
  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20230346947
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: November 15, 2022
    Publication date: November 2, 2023
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 11497812
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: November 15, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • METHODS AND COMPOSITIONS FOR INDUCING NEURAL PLASTICITY
    Publication number: 20210330757
    Abstract: A method of promoting compensatory plasticity of spared neural cells after a neural injury includes contacting the spared neural cells with an effective amount of a therapeutic agent comprising a therapeutic peptide, wherein the therapeutic peptide comprises an amino acid sequence with at least 70% identity to SEQ ID NO:32.
    Type: Application
    Filed: August 29, 2019
    Publication date: October 28, 2021
    Inventors: Jerry Silver, Yu Luo, Fucheng Luo
  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20210205460
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: August 3, 2020
    Publication date: July 8, 2021
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Compositions and methods of treating root avulsion injury
    Patent number: 10898550
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 26, 2021
    Assignees: CASE WESTERN RESERVE UNIVERSITY, VERSITECH LIMITED
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY
    Publication number: 20210008148
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 14, 2021
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • Compositions and methods for treating heart disease and/or injury
    Patent number: 10786541
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: September 29, 2020
    Assignees: CASE WESTERN RESERVE UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 10729777
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: August 4, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • COMPOSITIONS AND METHODS FOR TREATING MYELIN DISORDERS
    Publication number: 20200230205
    Abstract: A method of enhancing oligodendrocyte progenitor cell (OPC) migration, differentiation, proliferation and/or maturation in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: July 11, 2018
    Publication date: July 23, 2020
    Inventors: Jerry Silver, Fucheng Luo, Yan Yang
  • COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
    Publication number: 20200093890
    Abstract: A method inhibiting and/or reducing ?-amyloid accumulation and/or Tau aggregation in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases.
    Type: Application
    Filed: June 5, 2018
    Publication date: March 26, 2020
    Inventors: Yingjie Shen, Yuanzheng Gu, Jerry Silver, Bradley Lang
  • COMPOSITIONS AND METHODS OF TREATING ROOT AVULSION INJURY
    Publication number: 20200000888
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: April 11, 2019
    Publication date: January 2, 2020
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY
    Publication number: 20190290717
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: February 19, 2019
    Publication date: September 26, 2019
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • Compositions and methods of treating root avulsion injury
    Patent number: 10258672
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: April 16, 2019
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE UNIVERSITY OF HONG KONG
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng, Heng Li, Wutian Wu
  • Compositions and methods for treating heart disease and/or injury
    Patent number: 10206967
    Abstract: A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: February 19, 2019
    Assignees: CASE WESTERN RESERVE UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Bradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    Publication number: 20180228905
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 16, 2018
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-Lan Weng
  • Compositions and methods for inhibiting the activity of LAR family phosphatases
    Patent number: 9937242
    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: April 10, 2018
    Assignee: Case Western Reserve University
    Inventors: Bradley T. Lang, Jared M. Cregg, Jerry Silver, Yi-lan Weng
  • COMPOSITIONS AND METHODS OF TREATING ROOT AVULSION INJURY
    Publication number: 20170072026
    Abstract: A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTP?.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 16, 2017
    Inventors: Jerry Silver, Bradley T. Lang, Jared M. Cregg, Yi-Lan Weng