Patents by Inventor Jerry Z. Zhang

Jerry Z. Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diffusion cell testing methods and system containing biphasic receptor fluids
    Patent number: 10564140
    Abstract: An in vitro release testing method and system for testing the ability of formulations to deliver agents across a barrier membrane is disclosed. The method may comprise steps of providing a dosage of a semi-solid formulation containing the bioactive agent, a receptor solution, and a barrier membrane to separate the semi-solid formulation and the receptor solution. The receptor solution may be a biphasic solution or an immiscible solution. The semi-solid formulation may be contacted with one side of the barrier membrane and the receptor solution with the other side of the barrier membrane for a time sufficient to produce penetration of the barrier membrane by the semi-solid formulation. The receptor solution may be sampled and assayed to determine the concentration of the bioactive agent in the receptor solution.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: February 18, 2020
    Assignee: BUFFERAD Illinois Inc.
    Inventors: Wen Yang, Kenna Krone, Jerry Z. Zhang, Xiaoyan Xu
  • Topical compositions for improved delivery of active agents
    Patent number: 10328154
    Abstract: A topical composition and methods of making the composition is disclosed. The composition may comprise an ointment base, C11-C40 alcohols or acids, and a polymer. The ointment base may be in an amount of at least about 50% of the topical composition by weight. The polymer may be substantially soluble in the ointment base.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: June 25, 2019
    Assignee: BUFFERAD Illinois Inc.
    Inventors: Xiaoyan Xu, Wen Yang, Nguyet Le, Jerry Z. Zhang
  • TOPICAL COMPOSITIONS FOR IMPROVED DELIVERY OF ACTIVE AGENTS
    Publication number: 20190125880
    Abstract: A topical composition and methods of making the composition is disclosed. The composition may comprise an ointment base, C11-C40 alcohols or acids, and a polymer. The ointment base may be in an amount of at least about 50% of the topical composition by weight. The polymer may be substantially soluble in the ointment base.
    Type: Application
    Filed: October 27, 2017
    Publication date: May 2, 2019
    Inventors: Xiaoyan Xu, Wen Yang, Nguyet Le, Jerry Z. Zhang
  • DIFFUSION CELL TESTING METHODS CONTAINING BIPHASIC RECEPTOR FLUIDS
    Publication number: 20180292376
    Abstract: An in vitro release testing method and system for testing the ability of formulations to deliver agents across a barrier membrane is disclosed. The method may comprise steps of providing a dosage of a semi-solid formulation containing the bioactive agent, a receptor solution, and a barrier membrane to separate the semi-solid formulation and the receptor solution. The receptor solution may be a biphasic solution or an immiscible solution. The semi-solid formulation may be contacted with one side of the barrier membrane and the receptor solution with the other side of the barrier membrane for a time sufficient to produce penetration of the barrier membrane by the semi-solid formulation. The receptor solution may be sampled and assayed to determine the concentration of the bioactive agent in the receptor solution.
    Type: Application
    Filed: April 10, 2017
    Publication date: October 11, 2018
    Inventors: Wen Yang, Kenna Krone, Jerry Z. Zhang, Xiaoyan Xu