Patents by Inventor Jerzy Karczewski

Jerzy Karczewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ANTIMICROBIAL COMPOUND AND USES THEREOF
    Publication number: 20220133846
    Abstract: A novel lantibiotic peptide and a composition comprising the peptide in an antimicrobial effective amount are provided. A method for preparing the composition from a medium into which host cells produce the peptide is also provided. A method of inhibiting growth of microbial cells, killing microbial cells or treating a subject infected by microbial cells, comprising administering to the microbial cells or the subject an effective amount of the peptide or the composition is further provided. Where the microbial cells are on a surface, the method may further comprise administering the peptide or the composition to the surface.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 5, 2022
    Applicant: Fraunhofer USA Inc.
    Inventors: Jerzy Karczewski, Stephen John Streatfield, Yukari Maezato, Stephen Peter Krasucki, Christine Mikel Brown, Vidadi Yusibov
  • Radioligand and binding assay
    Patent number: 6838291
    Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1?-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4?-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 4, 2005
    Assignee: Merck & Co., Inc.
    Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
  • Radioligand and binding assay
    Publication number: 20020034730
    Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
    Type: Application
    Filed: July 12, 2001
    Publication date: March 21, 2002
    Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
  • Method for blocking platelet adhesion to collagen
    Patent number: 5179082
    Abstract: A method for blocking platelet adhesion to collagen by contacting platelets with a polypeptide having one of the following sequences:NH.sub.2 (Ch) Ala Arg Gly Asp (Cx) COOH (i)NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH (ii)NH.sub.2 (Ch) Ala Arg Tyr Asp (CX) COOH (iii)NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z (iv)wherein Ch, Cx, Cy are defined amino acid sequences or conservatively substituted amino acid sequences, and Z is NH.sub.2 or COOH.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: January 12, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. Connolly, Jerzy Karczewski