Patents by Inventor Jerzy PIECZYKOLAN

Jerzy PIECZYKOLAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-phenyl-4-hexynoic acid derivatives as GPR40 agonists
    Patent number: 11964938
    Abstract: A compound of the formula (I) wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom, and * denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: April 23, 2024
    Assignee: CELON PHARMA S.A.
    Inventors: Mateusz Mach, Radoslaw Dzida, Damian Smuga, Filip Stelmach, Mikolaj Matloka, Katarzyna Bazydlo, Krzysztof Dubiel, Maciej Wieczorek, Jerzy Pieczykolan
  • Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
    Patent number: 11072619
    Abstract: A compound or its acid addition salt of the general formula (I), wherein R1 represents phenyl substituted with one or two substituents selected from the group consisting of halogen and C1-C3 alkoxyl, or 6-membered heteroaryl with 1 or 2 nitrogen atoms, which is unsubstituted or substituted with a substituent selected from the group consisting of —NH2, halogen, alkyl C1-C4, alkoxyl C1-C3, and 6-membered heterocyclyl comprising 1 or 2 heteroatoms selected from the group consisting of N and O. The compound has the activity of kinase JAK1/JAK3 inhibitor and can find use in the treatment of chronic inflammatory and autoimmunological diseases.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: July 27, 2021
    Assignee: Celon Pharma S.A.
    Inventors: Michal Mroczkiewicz, Bartosz Stypik, Anna Bujak, Krzysztof Szymczak, Pawel Gunerka, Krzysztof Dubiel, Maciej Wieczorek, Jerzy Pieczykolan
  • 3-PHENYL-4-HEXYNOIC ACID DERIVATIVES AS GPR40 AGONISTS
    Publication number: 20200399198
    Abstract: A compound of the formula (I) wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3-C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom, and * denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes.
    Type: Application
    Filed: January 7, 2019
    Publication date: December 24, 2020
    Applicant: CELON PHARMA S.A.
    Inventors: Mateusz MACH, Radoslaw DZIDA, Damian SMUGA, Filip STELMACH, Mikolaj MATLOKA, Katarzyna BAZYDLO, Krzysztof DUBIEL, Maciej WIECZOREK, Jerzy PIECZYKOLAN
  • PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS
    Publication number: 20200199128
    Abstract: A compound or its acid addition salt of the general formula (I), wherein R1 represents phenyl substituted with one or two substituents selected from the group consisting of halogen and C1-C3 alkoxyl, or 6-membered heteroaryl with 1 or 2 nitrogen atoms, which is unsubstituted or substituted with a substituent selected from the group consisting of —NH2, halogen, alkyl C1-C4, alkoxyl C1-C3, and 6-membered heterocyclyl comprising 1 or 2 heteroatoms selected from the group consisting of N and O. The compound has the activity of kinase JAK1/JAK3 inhibitor and can find use in the treatment of chronic inflammatory and autoimmunological diseases.
    Type: Application
    Filed: May 10, 2018
    Publication date: June 25, 2020
    Applicant: CELON PHARMA S.A.
    Inventors: Michal MROCZKIEWICZ, Bartosz STYPIK, Anna BUJAK, Krzysztof SZYMCZAK, Pawel GUNERKA, Krzysztof DUBIEL, Maciej WIECZOREK, Jerzy PIECZYKOLAN