Patents by Inventor Jesús JIMÉNEZ BARBERO

Jesús JIMÉNEZ BARBERO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic complex for vaccination and method for the production thereof
    Patent number: 9901633
    Abstract: The present invention is related to an immunogenic complex comprising a polymerized antigen, mannan and a dialdehyde, the composition comprising it and the use thereof as an immune response stimulator and vaccine, useful in the treatment of infectious diseases, neoplasms and allergies. Likewise, the invention relates to the method for obtaining said immunogenic complex, based on the antigen and mannan simultaneous polymerization and conjugation by using a dialdehyde.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: February 27, 2018
    Assignee: IMMUNOTEK, S.L.
    Inventors: José Luis Subiza Garrido-Lestache, Javier Cañada Vicinay, Irene Soria Castro, Enrique Fernández-Caldas Rodríguez, Ana Manzano Pérez, Bárbara Cases Ortega, Jesús Jiménez Barbero, Miguel Casanovas Vergés
  • NEW C-GLYCOSYLPOLYPHENOL ANTIDIABETIC AGENTS, EFFECT ON GLUCOSE TOLERANCE AND INTERACTION WITH BETA-AMYLOID. THERAPEUTIC APPLICATIONS OF THE SYNTHESIZED AGENT(S) AND OF GENISTA TENERA ETHYL ACETATE EXTRACTS CONTAINING SOME OF THOSE AGENTS
    Publication number: 20170348340
    Abstract: The present invention concerns the antidiabetic activity of compounds type A, namely of 8-?-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to ?-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. The inhibitory activity of ?-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphastase by these two extracts and the diethyl ether plant extract is also part of the present invention.
    Type: Application
    Filed: August 21, 2017
    Publication date: December 7, 2017
    Inventors: Amélia Pilar GRASES SANTOS SILVA RAUTER, Ana Rita XAVIER DE JESUS, Alice Isabel MENDES MARTINS, Catarina Alexandra DOS SANTOS DIAS, Rogério José TAVARES RIBEIRO, Maria Paula BORGES DE LEMOS MACEDO, Jorge Alberto GUERRA JUSTINO, Helder DIAS MOTA FILIPE, Rui Manuel AMARO PINTO, Bruno Miguel NOGUEIRA SEPODES, Margarida Alexandra PATRÍCIO GOULART DE MEDEIROS, Jesus JIMENÉZ BARBERO, Cristina AIROLDI, Francesco NICOTRA
  • C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of ethyl acetate extracts containing some of those agents
    Patent number: 9775856
    Abstract: The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-?-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to ?-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. The inhibitory activity of ?-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: October 3, 2017
    Assignee: FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA
    Inventors: Amélia Pilar Grases Santos Silva Rauter, Ana Rita Xavier De Jesus, Alice Isabel Mendes Martins, Catarina Alexandra Dos Santos Dias, Rogério José Tavares Ribeiro, Maria Paula Borges De Lemos Macedo, Jorge Alberto Guerra Justino, Helder Dias Mota Filipe, Rui Manuel Amaro Pinto, Bruno Miguel Nogueira Sepodes, Margarida Alexandra Patrício Goulart De Medeiros, Jesus Jimenéz Barbero, Cristina Airoldi, Francesco Nicotra
  • IMMUNOGENIC COMPLEX FOR VACCINATION AND METHOD FOR THE PRODUCTION THEREOF
    Publication number: 20160058859
    Abstract: The present invention is related to an immunogenic complex comprising a polymerized antigen, mannan and a dialdehyde, the composition comprising it and the use thereof as an immune response stimulator and vaccine, useful in the treatment of infectious diseases, neoplasms and allergies. Likewise, the invention relates to the method for obtaining said immunogenic complex, based on the antigen and mannan simultaneous polymerization and conjugation by using a dialdehyde.
    Type: Application
    Filed: April 3, 2014
    Publication date: March 3, 2016
    Inventors: José Luis SUBIZA GARRIDO-LESTACHE, Javier CAÑADA VICINAY, Irene SORIA CASTRO, Enrique FERNÁNDEZ-CALDAS RODRÍGUEZ, Ana MANZANO PÉREZ, Bárbara CASES ORTEGA, Jesús JIMÉNEZ BARBERO, Miguel CASANOVAS VERGÉS
  • NEW C-GLYCOSYLPOLYPHENOL ANTIDIABETIC AGENTS, EFFECT ON GLUCOSE TOLERANCE AND INTERACTION WITH BETA-AMYLOID. THERAPEUTIC APPLICATIONS OF THE SYNTHESIZED AGENT(S) AND OF GENISTA TENERA ETHYL ACETATE EXTRACTS CONTAINING SOME OF THOSE AGENTS
    Publication number: 20150031639
    Abstract: The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-?-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to ?-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. The inhibitory activity of ?-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.
    Type: Application
    Filed: March 11, 2013
    Publication date: January 29, 2015
    Applicant: Universidade de Lisboa
    Inventors: Amélia Pilar Grases Santos Silva, Ana Rita Xavier De Jesus, Alice Isabel Mendes Martins, Catarina Alexandra Dos Santos Dia, Rogério José Tavares Ribeiro, Maria Paula Borges De Lemos Ma, Jorge Alberto Guerra Justino, Helder Dias Mota Filipe, Rui Manuel Amaro Pinto, Bruno Miguel Nogueira Sepodes, Margarida Alexandra Patrício Goul, Jesus Jimenéz Barbero, Cristina Airoldi, Francesco Nicotra