Abstract: Integrated particle capture and detection devices include a microimpactor system for capturing particles or other materials from a fluid stream. The captured materials are subject to in situ analysis, inactivation or chemical reactions. The devices are particularly suitable as air purification devices or personal protection devices, where the air is possibly contaminated with pathogenic or toxic materials. The device can indicate the presence of these materials, or can be used to deactivate them and thus render the air safe for breathing.