Abstract: In various examples, a plurality of poses corresponding to one or more configuration parameters within an environment—such as a location of a machine within an environment, an orientation of a machine within an environment, a sensor angle pose of a machine, or a sensor location of a machine—may be used to generate training data and corresponding ground truth data for training a machine learning model—such as a deep neural network (DNN). As a result, the machine learning model, once deployed, may more accurately compute one or more outputs—such as outputs representative of lane boundaries, trajectories for an autonomous machine, etc.—agnostic to machine and/or sensor poses of the machine within which the machine learning model is deployed.