Abstract: A method for estimating a crack propagation rate includes receiving a first dataset for a new material design, the new material design including crack growth rate data, receiving second and third datasets for a plurality of different legacy systems associated with an existing material design, determining a legacy model for each of the plurality of different legacy systems based on the respective second and third datasets for each of the plurality of different legacy systems and the first dataset for the new material design, the legacy model based on a validity of each legacy system, the validity determined using a legacy model likelihood validity and a predictive uncertainty model validity, calculating a model weight to associate with each of the determined legacy models, and determining a first multi-source model for new data for the new material design based on the model weight.

Abstract: A method and system to receive a dataset for a new design; receive datasets for a plurality of different legacy systems; determine a legacy model for each of the plurality of different legacy systems based on the respective dataset for each of the plurality of different legacy systems and the dataset for the new design; calculate a model weight to associate with each of the determined legacy models; determine, based on a combination of the determined legacy models for the plurality of different legacy systems and the weight associated therewith, a multi-source model for new data for the new design; and save a record of the determined multi-source model.

Abstract: A method and system to receive a dataset for a new design; receive datasets for a plurality of different legacy systems; determine a legacy model for each of the plurality of different legacy systems based on the respective dataset for each of the plurality of different legacy systems and the dataset for the new design; calculate a model weight to associate with each of the determined legacy models; determine, based on a combination of the determined legacy models for the plurality of different legacy systems and the weight associated therewith, a multi-source model for new data for the new design; and save a record of the determined multi-source model.

Abstract: The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectable transdermally by external optical means, and either each particles being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable. The invention relates to a process for the detection of an analyte using such a sensor, comprising implantation of the sensor into the skin of a mammal, transdermal detection of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.

Abstract: The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectable transdermally by external optical means, and either each particles being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable.