Abstract: Provided is a pharmaceutical composition which comprises a nucleophilic compound capable of inhibiting carbamylation, for use in the treatment of a condition involving cutaneous or connective tissue damage. A method for treating a condition involving cutaneous or connective tissue damage in a patient, is also provided, said method comprising administering a said pharmaceutical composition to said patient.

Abstract: There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypetides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine.

Abstract: There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypeptides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine.

Abstract: There is provided a topical formulation comprising a nucleophile, such as amino acids and most polypeptides and/or a derivative thereof, for use in the treatment or prevention of itchy dry skin caused by urea, such as in uremic pruritus, of a subject. The amino acid may be histidine and the derivative may be a histidine degradation product, a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine.

Abstract: A gas analyzer has a measuring chamber, a gas inlet channel, a gas outlet channel, a pump for providing a gas flow through the chamber, a device for irradiating the gas in the chamber with pulsating electromagnetic energy to generate acoustic pressure fluctuations therein, and at least one microphone communicating with the chamber for detecting the fluctuations. The inlet channel and the outlet channel each has an acoustic filter formed by channels with reduced sectional area of flow and a plurality of cavities associated therewith. The gas analyzer has at least one sandwich device formed of joined plate-like elements. The channel sections of the inlet and/or outlet channel are defined by at least two elements and the vibration-reducing cavities are also defined by at least two elements. The connections between the respective channels and cavities are formed as transverse apertures in the elements or element portions adjoining the channel and the cavities, respectively.

Abstract: Gas analyzer comprising a measuring chamber (3), a gas inlet channel (1), a gas outlet channel (14), a pump (13) for providing a gas flow through the measuring chamber (3), a device for irradiating the gas in the measuring chamber (3) with pulsating electromagnetic energy in form of infrared light so as to generate acoustic pressure fluctuations therein, and at least one microphone (9) communicating with the measuring chamber for detecting said pressure fluctuations. The inlet channel (1) and the outlet channel (14) each comprises an acoustic filter (2,11) in form of channel sections with reduced sectional area of flow (R1-R9) and a plurality of cavities (C1-C7) associated therewith.