Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Abstract: A permanent magnet module for a permanent magnet machine is provided, the permanent magnet module including a baseplate, at least a permanent magnet attached to the baseplate and a cover for at least partially covering the permanent magnet. The cover includes a stainless steel having a high magnetic permeability.

Abstract: The present invention relates to improved pharmaceutical compositions and dosage unit forms of bispecific CD3×CD20 antibodies and to routes of administration.

Abstract: The present invention relates to pharmaceutical compositions and dosage unit forms of bispecific CD3xCD20 antibodies and to routes of administration.

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Abstract: The present invention discloses a method for production of novel carbamylated erythropoietin and compositions comprising the novel carbamylated erythropoietin and pharmaceutical compositions comprising this and uses thereof.

Abstract: A refrigerant compressor (1) includes a cylinder block (4), in which a cylinder (14) is arranged, and a cylinder head (16), which covers the front side of the cylinder (14) and is connected to the cylinder block (4) by a plurality of threaded bolts (18, 19). It is endeavored to achieve a good performance with a small mass of the refrigerant compressor. For this purpose, it is ensured that at least two threaded bolts (18) extend through the cylinder block (4) and are screwed into a common mating thread element (23) at the end projecting from the cylinder block (4).

Abstract: Provided is a simplified design for spring retainers in a hermetically enclosed refrigerant compressor. A hermetically enclosed refrigerant compressor includes a hermetically tight enclosure, and an electrical motor unit and a compressor supported relative to the enclosure by springs. The electrical motor unit and compressor include a first spring retainer and the enclosure includes a second spring retainer. The first and second spring retainers hold springs such that the electrical motor and compressor are supported relative to the enclosure. The first spring retainer is integrated with the electrical motor unit and the compressor.

Abstract: The invention concerns a refrigerant compressor (1) with a cylinder block (4), in which a cylinder (14) is arranged, and a cylinder head (16), which covers the front side of the cylinder (14) and is connected to the cylinder block (4) by means of threaded bolts (18, 19). It is endeavored to achieve a good performance with a small mass of the refrigerant compressor. For this purpose, it is ensured that at least two threaded bolts (18) extend through the cylinder block (4) and are screwed into a common mating thread element (23) at the end projecting from the cylinder block (4).

Abstract: The invention concerns a refrigerant compressor arrangement (1) with a compressor block (21) comprising a compressor unit (9) with a cylinder formed in the compressor block, and with a motor (8) having a stator (12) and a rotor (13), the rotor being unrotatably connected to a drive shaft (31) driving the compressor unit (9), the drive shaft (31) being supported in a bearing section (32) of the compressor block (21). It is endeavoured to make the refrigerant compressor arrangement with a smaller total height. For this purpose, the bearing section (32) penetrates an active area of the stator (12) and that the rotor (13) and the drive shaft (31) are connected to each other outside the active area on the side of the rotor (13) facing away from the compressor unit (9).

Abstract: The invention concerns a hermetically enclosed refrigerant compressor arrangement (1) having a hermetically tight enclosure (2), a unit (7) comprising an electrical motor (8) with stator (14) and rotor (15) and a compressor (9) with cylinder head cover (48), and springs (10-12) fixed on the unit (7) via first spring retainers and on the enclosure via second spring retainers (59). It is endeavoured to simplify the design of the spring retaining means. For this purpose, at least one of the elements cylinder head cover (48) and end plate (23) of the stator (14) comprises at least one integrated first spring retainer (49, 50).

Abstract: The invention concerns a method and a blank (30) for manufacturing a compressor block of a small-type refrigeration appliance, particularly for a hermetically enclosed refrigerant compressor arrangement, the blank comprising a handling section (34) and at least two working areas (43, 46). The blank (30) is clamped in a working arrangement at a handling section (34), the blank being worked during maintenance of the clamping. It is endeavoured to reduce the dimensions of a compressor block, though maintaining the opportunity of performing several working steps during one clamping process. For this purpose, it is provided that the handling section (34) is removed after the working.