Patents by Inventor Jess Wagner-Whyte

Jess Wagner-Whyte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APTAMERS THAT BIND THROMBIN WITH HIGH AFFINITY
    Publication number: 20120149764
    Abstract: The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has been implicated. The invention further provides materials and methods for the administration of aptamers capable of binding to thrombin.
    Type: Application
    Filed: August 15, 2011
    Publication date: June 14, 2012
    Inventors: John L. Diener, Jess Wagner-Whyte, David Fontana
  • Aptamers that bind thrombin with high affinity
    Patent number: 7998939
    Abstract: The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has been implicated. The invention further provides materials and methods for the administration of aptamers capable of binding to thrombin.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: August 16, 2011
    Assignee: Archemix Corporation
    Inventors: John L. Diener, Jess Wagner-Whyte, David Fontana
  • Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
    Patent number: 7767803
    Abstract: The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2?-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: August 3, 2010
    Assignee: Archemix Corp.
    Inventors: John L. Diener, Paul Hatala, Jess Wagner-Whyte, Charles Wilson
  • Aptamers that bind thrombin with high affinity
    Publication number: 20090221680
    Abstract: The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has been implicated. The invention further provides materials and methods for the administration of aptamers capable of binding to thrombin.
    Type: Application
    Filed: August 23, 2006
    Publication date: September 3, 2009
    Inventors: John L. Diener, Jess Wagner-Whyte, David Fontana
  • Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics
    Publication number: 20090105172
    Abstract: The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2?-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
    Type: Application
    Filed: March 7, 2006
    Publication date: April 23, 2009
    Inventors: John L. Diener, Paul Hatala, Jason R. Killough, Jess Wagner-Whyte, Charles Wilson, Shuhao Zhu
  • Nucleic Acid Ligands Specific to Immunoglobuline E and Their Use as Atopic Disease Therapeutics
    Publication number: 20090018093
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Application
    Filed: December 1, 2005
    Publication date: January 15, 2009
    Inventors: Sharon Cload, John L. Diener, David Epstein, Jess Wagner-Whyte
  • Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
    Publication number: 20070041901
    Abstract: The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2?-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
    Type: Application
    Filed: March 7, 2006
    Publication date: February 22, 2007
    Inventors: John Diener, Paul Hatala, Jess Wagner-Whyte, Charles Wilson