Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A method for providing access to multi-file related tasks with version control is provided, including: receiving, through a task interface application executed by a client device, a command to open a task for processing by a local tool application on the client device, the command to open the task further identifying a specific version of the task; responsive to the command to open the task, transmitting, from the client device over a network to a server, a request for a plurality of files associated to the specific version of the task; receiving, by the client device over the network from the server, the plurality of files associated to the specific version of the task; initiating, by the task interface application, opening of the received plurality of files by the local tool application for editing on the client device.

Abstract: A version control system implemented on at least one server computer is provided, including: a database that stores a plurality of tasks, each task having one or more versions, each version of a given task having files that are associated thereto; a server process that manages versioning of the tasks; wherein responsive to a request to check-out a first version of the given task, the server process retrieves and serves files associated to the first version of the given task; wherein responsive to a request to check-in the previously checked-out first version of the given task, the server process generates a second version of the given task, and receives and stores files in association with the second version of the given task.

Abstract: A method includes: implementing a first asset management system at a first site; implementing a second asset management system at a second site; processing a first set of changes to a first copy of a task stored by the first asset management system; processing a second set of changes to a second copy of the task stored by the second asset management system, the first and second copies of the task being synchronized; receiving, by the second asset management system from the first asset management system, the second set of changes; receiving, by the first asset management system from the second asset management system, the second set of changes; applying merge rules to the first and second set of changes at the first site and the second site, to generate first and second copies of a new version of the task stored to the first and second asset management systems.

Abstract: A method for providing access to multi-file related tasks with version control is provided, including: receiving, through a task interface application executed by a client device, a command to open a task for processing by a local tool application on the client device, the command to open the task further identifying a specific version of the task; responsive to the command to open the task, transmitting, from the client device over a network to a server, a request for a plurality of files associated to the specific version of the task; receiving, by the client device over the network from the server, the plurality of files associated to the specific version of the task; initiating, by the task interface application, opening of the received plurality of files by the local tool application for editing on the client device.