Patents by Inventor Jesse D. Bloom

Jesse D. Bloom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for making random codon-mutant libraries and uses thereof
    Patent number: 10479989
    Abstract: The present disclosure relates to compositions and methods for randomly introducing codon-mutations in a target nucleic acid molecule and, more particularly, using wild-type and triplet-randomized oligonucleotides to introduce mutations uniformly across a target nucleotide of interest in a controlled fashion and with a low rate of insertions or deletions.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 19, 2019
    Assignee: Fred Hutchinson Cancer Research Center
    Inventor: Jesse D. Bloom
  • COMPOSITIONS AND METHODS FOR DIRECTED IMMUNOGEN EVOLUTION AND USES THEREOF
    Publication number: 20160199481
    Abstract: The present disclosure relates to compositions and methods for using a modified virus that infects a cell only if the virus presents a candidate antigen that binds with high affinity to a target antibody, thereby allowing for generation and identification of immunogens useful, for example, as vaccines.
    Type: Application
    Filed: August 21, 2014
    Publication date: July 14, 2016
    Inventor: Jesse D. Bloom
  • COMPOSITIONS FOR MAKING RANDOM CODON-MUTANT LIBRARIES AND USES THEREOF
    Publication number: 20160145603
    Abstract: The present disclosure relates to compositions and methods for randomly introducing codon-mutations in a target nucleic acid molecule and, more particularly, using wild-type and triplet-randomized oligonucleotides to introduce mutations uniformly across a target nucleotide of interest in a controlled fashion and with a low rate of insertions or deletions.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 26, 2016
    Inventor: Jesse D. Bloom