Abstract: Disclosed herein are methods, compositions and devices for diagnosing pathologic pulmonary vascular disease development, progression, and outcomes from cardiac surgical interventions, particularly surgical palliation in SVHD, and more particularly superior cavopulmonary anastomosis procedures. In particular, methods are provided for assessing risk of post-Stage 2 complications arising from intolerance of Stage 2 physiology due to e.g., pulmonary vascular inadequacy.

Abstract: Disclosed herein are methods, devices, and systems for accurately detecting and/or diagnosing a child having or at risk of developing necrotizing enterocolitis (NEC). In most embodiments, the child is currently suffering from congenital heart disease (CHD). The disclosed methods, devices, and systems may be useful in monitoring the administration and/or response to therapy for CHD and/or NEC. The disclosed methods, devices, and systems may involve detecting one or more biomarkers in a sample from the child, for example a plasma sample, wherein the sample is less than or equal to about 20 microliters.

Abstract: The present invention includes a method of inhibiting and/or reducing blood coagulation in a subject. The present invention further provides a method of treating and/or preventing inflammation and/or organ dysfunction in a subject.