Abstract: N-(6-(((2R,3S)-3,4-dihydroxy butan-2-yl)oxy)-2-((4-fluoro benzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide (compound 4), a known chemokine modulator, in combination with colchicine is useful in the treatment of diseases/conditions in which modulation of chemokine receptor activity, interleukin-1 (IL-1) activity, and/or myeloperoxidase (MPO) activity is beneficial. In particular, provided herein are compositions and methods for the treatment and prevention of such diseases/conditions.

Abstract: N-(6-(((2R,3S)-3,4-dihydroxy butan-2-yl)oxy)-2-((4-fluoro benzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide (compound 4), a known chemokine modulator, in combination with colchicine is useful in the treatment of diseases/conditions in which modulation of chemokine receptor activity, interleukin-1 (IL-1) activity, and/or myeloperoxidase (MPO) activity is beneficial. In particular, provided herein are compositions and methods for the treatment and prevention of such diseases/conditions.

Abstract: A system and method for using command buffers as timeslices or periods of execution for a long running compute task on a graphics processor. Embodiments of the present invention allow execution of long running compute applications with operating systems that manage and schedule graphics processing unit (GPU) resources and that may have a predetermined execution time limit for each command buffer. The method includes receiving a request from an application and determining a plurality of command buffers required to execute the request. Each of the plurality of command buffers may correspond to some portion of execution time or timeslice. The method further includes sending the plurality of command buffers to an operating system operable for scheduling the plurality of command buffers for execution on a graphics processor. The command buffers from a different request are time multiplexed within the execution of the plurality of command buffers on the graphics processor.

Abstract: An apparatus configured for dispensing flowable materials comprises a canister, a straining member, a lid, means for pressurizing a cavity of the canister and a dispensing tube assembly. The canister has a fill port and means for pressurizing the canister. The straining member is removably mounted within the fill port. The lid is removably mounted on the fill port. The lid and the fill port are jointly configured for providing a substantially air-tight seal therebetween when the lid is mounted on the fill port. The dispensing tube assembly is communicatively attached to the canister. The dispensing tube is configured for enabling flowable material within the cavity of the canister to be selectively dispensed through the dispensing tube assembly.

Abstract: Real-time processing includes per-point transfer matrices forming a high-dimensional surface signal that is compressed using clustered principal component analysis (CPCA). CPCA partitions multiple samples into fewer clusters, each cluster approximating the signal as an affine subspace. Further, source radiance is input to a processor, which approximates source radiance using spherical harmonic basis to produce a set of source radiance coefficients. A graphics processing unit (GPU) processes the source radiance coefficients through the transfer matrix model for each cluster. The result of such processing is the exit radiance, which parameterizes the radiance leaving the surface of the object at each point, thus producing the shading for each point of the virtual object in real time.