Patents by Inventor Jesse L. Bobbitt

Jesse L. Bobbitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification and refolding of recombinant proteins
    Patent number: 4923967
    Abstract: The present invention discloses a new method for solubilizing and refolding recombinant proteins expressed as granules. The method involves sulfitolysis and the formation of a precipitate of protein-S-sulfonate by warming. The precipitate has been found to contain protein in high purity. In addition, proper folding takes place if the desired protein is fully reduced and passed through an intermediate concentration of denaturant which allows for a transition between its folded and unfolded states.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: May 8, 1990
    Assignee: Eli Lilly and Company
    Inventors: Jesse L. Bobbitt, Joseph Manetta
  • Substrate for assay of plasmin
    Patent number: 4056519
    Abstract: The proteinase plasmin is assayed either colorimetrically or fluorometrically with a tripeptidyl-4-methoxy-2-naphthylamide substrate having the following general formula: ##STR1## The substrate is useful for either routine clinical assays or kinetic studies.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: November 1, 1977
    Assignee: Eli Lilly and Company
    Inventors: Jesse L. Bobbitt, Edward L. Smithwick, Jr.