Abstract: Apparatus, comprising: a sheath (22), advanceable through an endoscope (10), and having distal openings comprising a first opening (30a) and a plurality of second openings (30b) surrounding the first opening; a housing (24), coupled to a proximal portion of the sheath; a first needle (28a), extending through the housing and sheath toward the first opening; a plurality of second needles (28b), extending through the housing and sheath toward a respective second opening; a first handle (26a), slidably coupled to the housing along an axis such that the first needle slides through the sheath and a distal tip of the first needle moves with respect to the first opening; and a second handle (26b), slidably coupled to the housing along a different axis such that the second needles slide through the sheath and a distal tip of each second needle moves with respect to its respective second opening.

Abstract: An apparatus comprising: a sheath comprising a plurality of openings at a distal end; an elongate first needle extendible perpendicularly from said sheath through one of said plurality of openings; and an assembly comprising at least two second needles arranged in a predetermined pattern relative to said first needle, and extendible perpendicularly from said sheath, wherein, when extended from said distal end of said sheath: (i) each of said second needles extends a different length from said distal end of said sheath, (ii) at least a distal portion of each of said second needles is resiliently biased to extend laterally outwardly in relation to said first needle, and (iii) a lateral spread region defined by said distal portions of all of said second needles is determined based, at least in part, on a distance of said extending from said distal end of said sheath.

Abstract: Apparatus, comprising: a sheath (22), advanceable through an endoscope (10), and having distal openings comprising a first opening (30a) and a plurality of second openings (30b) surrounding the first opening; a housing (24), coupled to a proximal portion of the sheath; a first needle (28a), extending through the housing and sheath toward the first opening; a plurality of second needles (28b), extending through the housing and sheath toward a respective second opening; a first handle (26a), slidably coupled to the housing along an axis such that the first needle slides through the sheath and a distal tip of the first needle moves with respect to the first opening; and a second handle (26b), slidably coupled to the housing along a different axis such that the second needles slide through the sheath and a distal tip of each second needle moves with respect to its respective second opening.

Abstract: An apparatus comprising: a sheath comprising a plurality of openings at a distal end; an elongate first needle extendible perpendicularly from said sheath through one of said plurality of openings; and an assembly comprising at least two second needles arranged in a predetermined pattern relative to said first needle, and extendible perpendicularly from said sheath, wherein, when extended from said distal end of said sheath: (i) each of said second needles extends a different length from said distal end of said sheath, (ii) at least a distal portion of each of said second needles is resiliently biased to extend laterally outwardly in relation to said first needle, and (iii) a lateral spread region defined by said distal portions of all of said second needles is determined based, at least in part, on a distance of said extending from said distal end of said sheath.

Abstract: Apparatus, comprising: a sheath (22), advanceable through an endoscope (10), and having distal openings comprising a first opening (30a) and a plurality of second openings (30b) surrounding the first opening; a housing (24), coupled to a proximal portion of the sheath; a first needle (28a), extending through the housing and sheath toward the first opening; a plurality of second needles (28b), extending through the housing and sheath toward a respective second opening; a first handle (26a), slidably coupled to the housing along an axis such that the first needle slides through the sheath and a distal tip of the first needle moves with respect to the first opening; and a second handle (26b), slidably coupled to the housing along a different axis such that the second needles slide through the sheath and a distal tip of each second needle moves with respect to its respective second opening.

Abstract: Apparatus, comprising: a sheath (22), advanceable through an endoscope (10), and having distal openings comprising a first opening (30a) and a plurality of second openings (30b) surrounding the first opening; a housing (24), coupled to a proximal portion of the sheath; a first needle (28a), extending through the housing and sheath toward the first opening; a plurality of second needles (28b), extending through the housing and sheath toward a respective second opening; a first handle (26a), slidably coupled to the housing along an axis such that the first needle slides through the sheath and a distal tip of the first needle moves with respect to the first opening; and a second handle (26b), slidably coupled to the housing along a different axis such that the second needles slide through the sheath and a distal tip of each second needle moves with respect to its respective second opening.

Abstract: An apparatus, device and method are provided for endoscopically extracting multiple tissue samples from multiple locations without needing to completely retract the apparatus or device from the target tissue in the process. In some embodiments the device includes a sheath for delivering the device through a body lumen wall, an outer needle, an inner needle extendable from and retractable into the outer needle, the inner needle having a rotational feature to enable sequential entry of the inner needle at multiple angles relative to the outer needle; and a rotational control mechanism for controlling rotation of the inner needle thereby enabling tissue extraction from multiple locations in a target tissue, without sequentially exiting the body lumen wall.