Patents by Inventor Jesse M. McFarland

Jesse M. McFarland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURIFIED MULTIVALENT PROTEIN-HYALURONIC ACID POLYMER CONJUGATES
    Publication number: 20230405133
    Abstract: The present invention relates to purified hyaluronic acid conjugates comprising biologically active peptides. The invention further relates to pharmaceutical compositions of the conjugates, and methods of preparing them.
    Type: Application
    Filed: April 14, 2023
    Publication date: December 21, 2023
    Inventors: Wesley M. JACKSON, Amy A. TWITE, Adam BARNEBEY, Livia Wilz BRIER, Jesse M. MCFARLAND
  • HUMANIZED MULTIVALENT PROTEIN CONJUGATES
    Publication number: 20230406916
    Abstract: The present invention relates to peptide sequences having a high degree of humanness and/or the ability to be expressed in appreciable levels in culture media, such as in E. coli. The peptides can be covalently attached via an alpha-helical peptide linker to a polymer backbone. The invention further relates to methods of preparing the peptides, polymer conjugates comprising the peptides, and pharmaceutical compostions thereof.
    Type: Application
    Filed: April 14, 2023
    Publication date: December 21, 2023
    Inventors: Wesley M. JACKSON, Amy A. TWITE, Adam BARNEBEY, Livia Wilz BRIER, Jesse M. MCFARLAND
  • Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy
    Publication number: 20230256109
    Abstract: Trans-cyclooctene conjugates of immunomodulatory agents may be used for bioorthogonal delivery to a targeted location in a subject. The compositions and methods have applications in the treatment of cancer, tumor growths, and immunotherapy.
    Type: Application
    Filed: August 6, 2021
    Publication date: August 17, 2023
    Inventors: Jose Manuel Mejia Oneto, Nathan A. Yee, Sangeetha Srinivasan, Michael Zakharian, Jesse M. McFarland
  • N-cyano-7-azanorbornane derivatives and uses thereof
    Patent number: 11572374
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: February 7, 2023
    Assignee: AMGEN INC.
    Inventors: John R. Butler, Daniel Erlanson, Russell Graceffa, Jeffrey Iwig, Joon Won Jeong, Ryan D. White, Yongwei Wu, Shuyan Yi, Xiao Mei Zheng, Jesse M. McFarland, Abhisek Banerjee
  • N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF
    Publication number: 20220363694
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
    Type: Application
    Filed: August 13, 2019
    Publication date: November 17, 2022
    Applicants: Amgen Inc., Carmot Therapeutics, Inc.
    Inventors: John R. BUTLER, Daniel ERLANSON, Russell GRACEFFA, Jeffrey IWIG, Joon Won JEONG, Ryan D. WHITE, Yongwei WU, Shuyan YI, Xiao Mei ZHENG, Jesse M. MCFARLAND, Abhisek BANERJEE
  • Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate
    Patent number: 11376334
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: July 5, 2022
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • Anti-Her2 Antibody-Maytansine Conjugates and Methods of Use Thereof
    Publication number: 20220023440
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: July 22, 2021
    Publication date: January 27, 2022
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Anti-HER2 antibody-maytansine conjugates and methods of use thereof
    Patent number: 11097013
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: August 24, 2021
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Hydrazinyl-Substituted Heteroaryl Compounds and Methods for Producing a Conjugate
    Publication number: 20200405876
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Application
    Filed: July 22, 2020
    Publication date: December 31, 2020
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate
    Patent number: 10758628
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: September 1, 2020
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • ANTI-CD22 ANTIBODY-MAYTANSINE CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20200246480
    Abstract: The present disclosure provides anti-CD22 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: November 8, 2016
    Publication date: August 6, 2020
    Inventors: David RABUKA, Jesse M. MCFARLAND, Penelope M. DRAKE, Robyn M. BARFIELD
  • Hydrazinyl-Substituted Heteroaryl Compounds and Methods for Producing a Conjugate
    Publication number: 20190192680
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 27, 2019
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • ANTI-HER2 ANTIBODY-MAYTANSINE CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20190111151
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: September 26, 2018
    Publication date: April 18, 2019
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Hydrazinyl-substituted heteroaryl compounds and methods for producing a conjugate
    Patent number: 10195283
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: February 5, 2019
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • Anti-HER2 antibody-maytansine conjugates and methods of use thereof
    Patent number: 10124070
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: November 13, 2018
    Assignee: Redwood Bioscience, Inc.
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland
  • Hydrazinyl-Substituted Heteroaryl Compounds and Methods for Producing a Conjugate
    Publication number: 20170266302
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • Anti-Her2 Antibody-Maytansine Conjugates and Methods of Use Thereof
    Publication number: 20150352225
    Abstract: The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
    Type: Application
    Filed: May 27, 2015
    Publication date: December 10, 2015
    Inventors: David Rabuka, Aaron Edward Albers, Robyn M. Barfield, Gregory W. deHart, Penelope M. Drake, Romas Alvydas Kudirka, Albert W. Garofalo, Jesse M. McFarland