Abstract: According to some embodiments, a skin treatment system comprises a manifold assembly comprising at least one fluid connector to secure at least one treatment fluid container, a primary handpiece configured to hydraulically couple to the manifold assembly, wherein the primary handpiece is hydraulically coupled to the manifold assembly using at least one fluid conduit, and a flow control device positioned along the at least one fluid conduit, the flow control device configured to switch flow of treatment fluid from the at least one treatment fluid between the primary handpiece and a port, wherein the port is configured to be coupled to a secondary handpiece, wherein a vacuum source is configured to operatively couple to the system and selectively create suction along the primary handpiece.