Abstract: The present disclosure provides compositions comprising biogels and hydrogels comprising lipid nanoparticles (LNPs) comprising nucleic acids encoding target antigens along with modified immune cells or precursors thereof (e.g., T cells) comprising chimeric antigen receptors (CARs). Methods of treating disease (e.g., cancer) by administering said compositions to a subject in need thereof, are also provided.

Abstract: The present disclosure provides compositions comprising modified immune cells or precursors thereof (e.g. T cells) comprising chimeric antigen receptors (CARs) along with modified cells comprising lipid nanoparticles (LNPs) comprising a nucleic acids encoding a truncated target antigens. Methods of treating disease (e.g. cancer) by administering said compositions to a subject in need thereof, are also provided.

Abstract: The disclosure features amphiphilic ligand conjugates including an EGFR peptide as well as immune cells modified with EGFR receptors. The disclosure also features compositions and methods of using the same, for example, to stimulate proliferation of T cell receptor expressing cells.

Abstract: A protective face mask having a main textile portion adapted to be worn over the mouth and nose, and comprising a perimeter and a filter portion. The mask further comprises a deformable member secured to the main textile portion near the perimeter, the deformable member circumscribing at least a majority of main textile portion, and being adapted to be conformed to the physical features of a user's face through the use of pressure, such that when the deformable member is so conformed, the mask will fit snugly against the user's face so that gaps between skin and the deformable member are reduced, thereby creating an inner air space; and, a mask securing system operatively affixed to the main textile portion for keeping the face mask securely in place during breathing; wherein the filter adapted to permit the exchange air between the environment and the inner air space.

Abstract: An ultraviolet reactor for irradiating a flow of fluid includes a set of UV lamps and baffles spaced along the ramps. The baffles generate helical flow of the fluid flowing along the lamps to enhance exposure of microorganisms carried in the fluid to UV radiation.