Abstract: LC techniques are disclosed. The LC technique includes providing a liquid chromatography system having a coated metallic fluid-contacting element, and transporting a fluid to contact the coated metallic fluid contacting element. Conditions for the transporting of the fluid are selected from the group consisting of the temperature of the fluid being greater than 150 degree Celsius, pressure urging the fluid being greater than 60 MPa, the fluid having a protein-containing analyte incompatible with one of titanium and polyether ether ketone, the fluid having a chelating agent incompatible with the one or both of the titanium or the polyether ether ketone.

Abstract: Bacillus strain compositions and methods for reducing growth of one or more mastitis-causing organisms and/or reducing a symptom, sign, or occurrence of mastitis in animals are provided. The Bacillus strain composition can comprise a bacterial cell, a spore, a forespore, and/or a combination of cells, spores, and/or forespores of Bacillus subtilis 839, Bacillus subtilis 4976, and/or an active variant thereof. Compositions and methods provided herein can be applied to beddings of animals, such as dairy cows, and can reduce symptoms, signs, and/or occurrences of mastitis (e.g., environmental mastitis) in the animals and/or reduce somatic cell count in the milk produced by the animals. Beddings for animals comprising the Bacillus strain compositions provided herein in an effective amount to reduce growth of one or more mastitis-causing organisms are also provided.

Abstract: Cold thermal chemical vapor deposition coatings, articles, and processes are disclosed. Specifically, a cold thermal chemical vapor deposition process includes positioning an article, heating a precursor gas to at least a decomposition temperature of the precursor gas to produce a deposition gas, introducing the deposition gas to a coating vessel, and depositing a coating from the deposition gas onto the article within the coating vessel. The article remains at a temperature below the decomposition temperature throughout the introducing and depositing of the deposition gas. The coating on the article has a gradient formed by the depositing of the coating having no flow for a period of time. The coated article includes a thermally-sensitive substrate (the thermally-sensitive substrate capable of being modified by a temperature of 300 degrees Celsius) and a coating the thermally-sensitive substrate.

Abstract: Disclosed herein are systems and methods for providing targeted temperature management (TTM) therapy to a patient. For example, TTM systems include a connection system for coupling a fluid deliver line to a thermal contact pad. The connection system is configured to provide indication to the user that the fluid deliver line is completely connected to thermal contact pad. In addition, the connection system also includes a controller for activating a connection lock and for sharing signals with a TTM system module. The fluid deliver line includes a pair of conduits arranged concentrically and the thermal pad includes a TTM fluid filter disposed within a fluid containing layer.

Abstract: A vehicle includes a support structure. The vehicle also includes a side door operable to move relative to the support structure between an open position and a closed position. In the open position of the side door, access to a vehicle interior of the vehicle is provided. In the closed position of the side door, the side door extends across a longitudinal centerline of the vehicle. The vehicle further includes a plurality of pivot members, each pivotably coupled to the support structure at a first end and pivotably coupled to the side door at a second end. The side door is movable between the open and closed positions via pivotal movement of each of the plurality of pivot members relative to the support structure and pivotal movement of the side door relative to each of the plurality of pivot members.

Abstract: A method for training a control system model includes introducing a simulated fault into a software simulation of a physical system and generating emulated sensor data based on the simulated fault, where the emulated sensor data emulates output from one or more sensors of the physical system. The method further includes obtaining output data from a test control system provided with the emulated sensor data, where the test control system emulates a control system of the physical system and tagging the output data with the simulated fault to create training data. The method further includes utilizing the training data to train the control system model, where the control system model is a machine learning model for use with the control system of the physical system during operation of the physical system.

Abstract: A crime center system generating a graphical user interface (GUI), which may be map-based, that facilitates efficient following of a moving object across cameras covering a geographic area. The system processes information on a network of cameras to determine the locations the cameras and their orientations. An object-tracking interface is generated by the system that includes an active camera view window presenting video from a camera capturing video of the geographic area that includes the tracked object. The system determines a set of the cameras, based on known locations and orientations, capturing images about the geographic space captured by the active camera. The system generates a “halo” of camera icons in the object-tracking interface around the periphery of the active camera view window, which provides a 360-degree view of available cameras about the active camera's location allowing a user to select a next active camera to efficiently track an object.

Abstract: A microprocessor executable method and system for determining the semantic relatedness and meaning between at least two natural language sources is described in a prescribed context. Portions of natural languages are vectorized and mathematically processed to express relatedness as a calculated metric. The metric is associable to the natural language sources to graphically present the level of relatedness between at least two natural language sources. The metric may be re-determined with algorithms designed to compare the natural language sources with a knowledge data bank so the calculated metric can be ascertained with a higher level of certainty.

Abstract: Systems and methods for synchronous content viewing are provided. In embodiments, a method includes providing an interface to a user of a remote user device; receiving a user selection of one or more contacts of the user as invitees to a synchronized session; providing content synchronously to the remote user device of the user and other remote user devices of the respective one or more contacts of the user based on receiving an acceptance from the one or more contacts of the user, wherein the user and the one or more contacts of the user view the content synchronously during the synchronized session; and providing functions of an application to the participants synchronously, wherein the functions enable the participants to interact with the content in real-time during the synchronized session, and wherein all participants view interactions with the content simultaneously.

Abstract: An electrosurgical system includes an electrosurgical unit electrically coupled to a surgical retractor. The electrosurgical unit includes an RF output and an RF return. The surgical retractor includes a return pad electrically coupled to the RF return of the electrosurgical unit. The electrosurgical unit includes an RF output configured to be coupled to an electrosurgical device, such as an electrosurgical device configured in a monopolar mode. A controller is configured to determine an impedance in tissue at a surgical area electrically disposed between the RF output and the and the RF return. The surgical retractor includes a handle and a blade configured to interface with tissue. The blade includes a return electrode.

Abstract: An electrosurgical system includes an electrosurgical unit electrically coupled to a surgical retractor. The electrosurgical unit includes an RF output and an RF return. The surgical retractor includes a return pad electrically coupled to the RF return of the electrosurgical unit. The electrosurgical unit includes an RF output configured to be coupled to an electrosurgical device, such as an electrosurgical device configured in a monopolar mode. A controller is configured to determine an impedance in tissue at a surgical area electrically disposed between the RF output and the and the RF return. The surgical retractor includes a handle and a blade configured to interface with tissue. The blade includes a return electrode.

Abstract: Disclosed herein is a system, apparatus and method directed to patient temperature control. The system can include a control module configured to provide fluid that is heated or cooled, a heating and cooling system configured to couple with the control module and receive the fluid, and a temperature sensor coupled to the control module, the temperature sensor configured to measure a body temperature of a patient and provide signals to the control module that indicate the body temperature. The system can include a neurostimulation device coupled to the control module to provide neurostimulation to the patient. The control module can include logic, stored on non-transitory, computer-readable medium that, when executed by one or more processors, causes performance of operations including generation and transmission of first instructions to the neurostimulation device causing initiation of a first neurostimulation procedure.

Abstract: In one or more arrangements, a tag system for monitoring of livestock is presented. The system includes at least one tag and a control system communicatively connected to the tag. In one or more arrangements, the tag includes a housing and a connector configured to operably connect with the housing to facilitate attachment of the tag to an animal. The tag also includes a set of sensors. In one or more arrangements, the set of sensors includes a first temperature sensor configured to monitor a temperature of the animal (animal reference temperature), a second temperature sensor configured to monitor an ambient temperature (ambient reference temperature) of the environment where the animal is located, a gyroscopic sensor, and/or an accelerometer sensor. In one or more arrangements, the tag includes an electronic circuit positioned within the housing and configured to communicate data from the set of sensors to the control system.

Abstract: A heating mat system is presented for use with livestock. The heating mat system includes a heating layer positioned between an upper support pad and a lower support pad. The heating layer includes a conductive microfilm that has a generally planar shape extending between a front edge, a rear edge, and opposing side edges. In one or more arrangements, the conductive microfilm includes a layer of graphene. In one or more arrangements, the heating mat system has a first electrical contact and a second electrical contact that are connected to the conductive microfilm. When a voltage difference is applied between the first electrical contact and the second electrical contact, current flows through the conductive microfilm, thereby generating heat to the heating mat system and heating livestock positioned on the system.

Abstract: In one or more arrangements, a heating system is provided having one or more heating panels positioned in a housing. The housing has a hollow interior with an open lower end. A first panel is positioned in the open lower end of the housing. The first heating panel includes a heating layer. The heating layer includes a conductive microfilm. A first electrical contact is connected to the conductive microfilm. A second electrical contact is connected to the conductive microfilm. In one or more arrangements, the conductive microfilm includes at least one layer of graphene or nanofiber carbon material. Application of a voltage difference between the first electrical contact and the second electrical contact causes current to flow through the conductive microfilm, thereby generating heat. In one or more arrangements, current which flows through the conductive microfilm causes the conductive microfilm to emit infrared radiation.

Abstract: The present disclosure provides novel cancer therapies. The treatment of cancers harboring EP300 mutations with CREBBP inhibition therapy is described.

Abstract: An electrosurgical unit configured to regulate a RF input signal applied to an electrosurgical device, the electrosurgical unit including a PWM circuit to produce a DC voltage responsive to a control signal; an RF waveform generator configured to generate an RF waveform based at least in part on the DC voltage; a transformer configured to transform the RF waveform to the RF input signal in a forward direction across the isolation barrier and transform a leakage current to a feedback current in a reverse direction across the isolation barrier; and a control circuit configured to generate the control signal based at least in part on the first input signal and the second input signal, the control signal controlling a pulse width modulation of the PWM circuit to produce the RF input signal.

Abstract: Disclosed are fluid delivery lines (“FDLs”) of systems, pads, and methods for targeted temperature management. A system can include a control module, a primary FDL, a secondary FDL, and one or more pads for placement on one or more portions of a patient's body, respectively. The primary FDL can be configured to convey a temperature-controlled fluid as a supply fluid from a hydraulic system of the control module and convey a return fluid back to the hydraulic system. Each pad of the one-or-more pads can include a multilayered pad body including a conduit layer configured to convey the supply fluid therethrough. The secondary FDL can be configured to convey the supply fluid from the primary FDL and convey the return fluid back to the primary FDL. The secondary FDL can include a pair of piercing tips configured to pierce the primary tubing for fluidly connecting the primary and secondary FDLs.

Abstract: Disclosed are systems and methods for performing targeted temperature management including a thermal pad having a thermoelectric device. A pad controller may regulate the temperature of the thermal pad. The thermal pad temperature can facilitate cooling and/or warming of the patient. The pad can include a thermal conduction layer and a skin contact layer. The system may include a controller to set the pad temperature of multiple thermal pads according to a TTM therapy. The thermal pad and the system can incorporate data from temperature sensors coupled to the thermoelectric device and the patient. The system controller may be coupled to the thermal pads via a wired or wireless connection.

Abstract: Disclosed are indicators for confirming fluid connections in systems, pads, and methods thereof for targeted temperature management. For example, a pad can include a multilayered pad body, a pad inlet connector, a pad outlet connector, and an indicator for visual indication of charging a conduit layer of the pad body with a supply fluid and confirmation of accurate fluid connections. The conduit layer includes one or more conduits for conveying a temperature-controlled fluid as the supply fluid from a hydraulic system of a control module as well as convey a return fluid back to the hydraulic system. A thermally conductive adhesive layer over the conduit layer is for placement on a portion of a patient's body. The pad inlet connector includes a pad inlet for charging the conduit layer with the supply fluid. The pad outlet connector includes a pad outlet for discharging the return fluid from the conduit layer.