Patents by Inventor Jessica A. Palmer

Jessica A. Palmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO ASSAY TO PREDICT CARDIOTOXICITY
    Publication number: 20210072230
    Abstract: The invention provides methods for predicting whether compounds are cardiotoxic by analyzing their effects on the ratios of concentrations of metabolites in cultured heart muscle cells.
    Type: Application
    Filed: March 8, 2019
    Publication date: March 11, 2021
    Inventors: Jessica A. Palmer, Alan M. Smith, Robert Burrier
  • PREDICTING HUMAN DEVELOPMENTAL TOXICITY OF PHARMACEUTICALS USING HUMAN STEM-LIKE CELLS AND METABOLOMIC RATIOS
    Publication number: 20190128872
    Abstract: This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.
    Type: Application
    Filed: December 18, 2018
    Publication date: May 2, 2019
    Inventors: Alan M. Smith, Paul R. West, Jessica Palmer
  • Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios
    Patent number: 10209240
    Abstract: This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: February 19, 2019
    Assignee: Stemina Biomarker Discovery, Inc.
    Inventors: Alan Smith, Paul West, Jessica Palmer
  • PREDICTING HUMAN DEVELOPMENTAL TOXICITY OF PHARMACEUTICALS USING HUMAN STEM-LIKE CELLS AND METABOLOMIC RATIOS
    Publication number: 20180128814
    Abstract: This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 10, 2018
    Inventors: Alan Smith, Paul West, Jessica Palmer
  • PREDICTING HUMAN DEVELOPMENTAL TOXICITY OF PHARMACEUTICALS USING HUMAN STEM-LIKE CELLS AND METABOLOMIC RATIOS
    Publication number: 20150301025
    Abstract: This present invention provides rapid, reproducible, biomarker-based screening methods for the developmental toxicity testing of compounds. The methods are designed to identify the exposure level at which a test compound perturbs metabolism in a manner predictive of developmental toxicity. In particular, the perturbation of two metabolites, ornithine and cystine, is measured, wherein a ratio of the fold change in ornithine to the fold change in cystine of less than or equal to about 0.88 is indicative of the teratogenicity of a test compound.
    Type: Application
    Filed: November 1, 2013
    Publication date: October 22, 2015
    Applicant: Stemina Biomarker Discovery, Inc.
    Inventors: Alan Smith, Paul West, Jessica Palmer
  • Vehicle taillamp
    Patent number: D1017849
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: March 12, 2024
    Assignee: Canoo Technologies Inc.
    Inventors: Jackson E. Luttig, Richard Kim, Brian Oh, Jessica Palmer, Zu-Ning Chen