Abstract: An assembly for securing a tailgate to a cargo bed includes, among other things, a strap having a first leg spaced from a second leg, and a fastener moveable to an engaged position with the strap. The fastener in the engaged position extends through a first aperture in the first leg to threadably engage a second aperture in the second leg. When the fastener is in the engaged position, the fastener and the strap are configured to secure a tailgate to a cargo bed.

Abstract: The present disclosure is concerned with xanthine analogs, methods of making xanthine analogs, and methods of treating West Nile virus using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A disposable pant may include a topsheet, a backsheet, an absorbent core disposed between the topsheet and the backsheet, and a leg gasketing system. The leg gasketing system may include an inner cuff and an outer cuff. The inner cuff may include an inner cuff folded edge and an inner cuff material edge and the outer cuff may include an outer cuff folded edge and an outer cuff material edge such that the web of material is folded laterally inward to form the outer cuff folded edge and folded laterally outward to form the inner cuff folded edge.

Abstract: A reversible or hybrid mattress topper includes a first foam plate having a first density, a second foam plate having a second density different than the first density of the first foam plate, and a spring panel that is disposed between the first foam plate and the second foam plate. The spring panel includes a plurality of coil springs positioned between an upper fabric layer and a lower fabric layer, with the upper and lower fabric layers joined together. An insulating layer extends along an outside surface of each of the first foam plate and the second foam plate.

Abstract: Embodiments facilitate interoperability and secure determination of healthcare costs. An entity may receive a first Electronic Health Record (EHR) sub-block with patient medical coverage information and first treatments and may transmit a first Device Drug Information (DIR) sub-block comprising first treatment classes corresponding to each first treatment, first treatment class members corresponding to each first treatment class, and corresponding first treatment class member cost information. In response, the entity may receive a second EHR sub-block comprising second treatments each: associated with a corresponding first treatment, and selected from corresponding first treatment class members. Upon receipt of a transaction confirmation, the entity may augment a multi-dimensional blockchain with a multi-dimensional block formed by linking: a DIR block including second treatment information, an EHR block including information based on the second EHR sub-block and a transaction block.

Abstract: Embodiments facilitate interoperability and secure patient selection for clinical trials and drug/device deployments. An entity may obtain a first set of health parameters and collective demographic information associated with one or more population segments and receive Electronic Health Record (EHR) sub-blocks with patient profile information and corresponding patient medical histories for patients. The entity may determine a subset of eligible candidate patients for a treatment based on information in the EHR sub-blocks and eligibility criteria for the treatment, which may be based the first set of health parameters, and/or the collective demographic information.

Abstract: A tailgate assembly for a vehicle includes, among other things, a tailgate configured to pivot relative to a vehicle body between a closed position, a fully open position, and a secondary position that is between the closed position and the fully open position. The assembly further includes a cable device having a tailgate connector and a vehicle connector. The tailgate connector is coupled to the tailgate. The vehicle connector couples to a sidewall of the vehicle in first position to support the tailgate in the fully open position. The vehicle connector couples to the sidewall of the vehicle in a second position to support the tailgate in a secondary position. The first position is vertically below the second position. The assembly still further includes a bracket that blocks removal of the tailgate from the vehicle body when the tailgate is in the fully open position and when the tailgate is in the secondary position.

Abstract: Provided herein are methods of amplifying and detecting drug resistance markers (e.g., antibiotic resistance genes) from pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

Abstract: Provided herein are methods of amplifying and detecting biothreat pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

Abstract: Provided herein are methods of amplifying and detecting pathogens and drug resistance markers (e.g., antibiotic resistance genes) in complex samples (e.g., blood), as well as related panels and compositions (e.g., primers, probes, magnetic particles, systems, cartridges, and kits). The methods, panels, and compositions can be used for comprehensive detection of pathogens and drug resistance markers for patient identification, patient selection, optimization of therapies, and antimicrobial stewardship.

Abstract: Provided herein are methods of detecting and sequencing target nucleic acids in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

Abstract: A method, computer system, and a computer program product for computing a product drag effect is provided. The present invention may include receiving a plurality of transaction record data. The present invention may then include tuning a plurality of parameters based on the received transaction record data. The present invention may further include determining a product drag frequency based on the authorized parameter tuning and received transaction record data. The present invention may then include calculating a drag probability based on the determined product drag frequency. The present invention may then include deriving an observation from the calculated drag probability. The present invention may lastly include outputting the derived observation to a user.

Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: An assembly for securing a tailgate to a cargo bed includes, among other things, a strap having a first leg spaced from a second leg, and a fastener moveable to an engaged position with the strap. The fastener in the engaged position extends through a first aperture in the first leg to threadably engage a second aperture in the second leg. When the fastener is in the engaged position, the fastener and the strap are configured to secure a tailgate to a cargo bed.

Abstract: A financial close automation (FCA) system receives or retrieves account data from one or more enterprise resource planning products (ERPs). The FCA examines the balance sheet for a given account and determines whether the account is auto-certifiable, and whether the unknown balance is below a threshold amount. If the answer to either inquiry is no, the FCA generates a task for the general ledger owner to provide an explanation for the discrepancy. A task is the created for a manager to review the provided explanation. If the manager does not approve of the provided explanation, additional information may be required. Once the manager approves the provided explanation for the discrepancy, the account is certified. If the account is auto-certifiable and the unknown balance is below the threshold amount, the account is auto-certified.

Abstract: The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

Abstract: This invention relates to a breast support garment for use in active environments, where the wearer of such garment is engaged in an activity that results in accelerating movements. In some preferred embodiments, these garments may be athletic or sports bras that redirect momentum related to a wearer's accelerating movements, for example, during exercise.

Abstract: A tailgate assembly for a vehicle includes, among other things, a tailgate configured to pivot relative to a vehicle body between a closed position, a fully open position, and a secondary position that is between the closed position and the fully open position. The assembly further includes a cable device having a tailgate connector and a vehicle connector. The tailgate connector is coupled to the tailgate. The vehicle connector couples to a sidewall of the vehicle in first position to support the tailgate in the fully open position. The vehicle connector couples to the sidewall of the vehicle in a second position to support the tailgate in a secondary position. The first position is vertically below the second position. The assembly still further includes a bracket that blocks removal of the tailgate from the vehicle body when the tailgate is in the fully open position and when the tailgate is in the secondary position.