Patents by Inventor Jessica O'Rear

Jessica O'Rear has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11105819
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: August 31, 2021
    Assignee: CRIMSON U.S. ASSETS LLC
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Publication number: 20210024652
    Abstract: The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
    Type: Application
    Filed: April 14, 2020
    Publication date: January 28, 2021
    Inventors: Gary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
  • Publication number: 20210007361
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: September 28, 2020
    Publication date: January 14, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN D GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10820596
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: November 3, 2020
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Steven D Gruver, Heather Kozy, Jessica O'Rear, Barbara Rosen, Ute Schellenberger, Jun-Zhi Wei, Weiping Xie, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20200158739
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Patent number: 10641781
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: May 5, 2020
    Assignee: CRIMSON U.S. ASSETS LLC
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Patent number: 10618975
    Abstract: The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: April 14, 2020
    Assignee: YALE UNIVERSITY
    Inventors: Gary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
  • Patent number: 10563221
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: February 18, 2020
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Lu Liu, Jessica O'Rear, Young-Jun Park, Barbara Rosen, Ute Schellenberger, Eric Schepers, Jun-Zhi Wei, Weiping Xie, Nasser Yalpani, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20190387749
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: September 11, 2019
    Publication date: December 26, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN D. GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10448648
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: October 22, 2019
    Assignee: PIONEER HI-BRED INTERANTIONAL, INC.
    Inventors: Steven Gruver, Heather Kozy, Jessica O'Rear, Barbara Rosen, Ute Schellenberger, Jun-Zhi Wei, Weiping Xie, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20190194355
    Abstract: The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
    Type: Application
    Filed: March 7, 2019
    Publication date: June 27, 2019
    Inventors: Gary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
  • Publication number: 20190142013
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 28, 2019
    Publication date: May 16, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10273311
    Abstract: The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: April 30, 2019
    Assignee: YALE UNIVERSITY
    Inventors: Gary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
  • Patent number: 10231460
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: March 19, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Steven Gruver, Heather Kozy, Jessica O'Rear, Barbara Rosen, Ute Schellenberger, Jun-Zhi Wei, Weiping Xie, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20180273974
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: June 6, 2018
    Publication date: September 27, 2018
    Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: LU LIU, JESSICA O'REAR, YOUNG-JUN PARK, BARBARA ROSEN, UTE SCHELLENBERGER, ERIC SCHEPERS, JUN-ZHI WEI, WEIPING XIE, NASSER YALPANI, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10006045
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: June 26, 2018
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Lu Liu, Jessica O'Rear, Young Jun Park, Barbara Rosen, Ute Schellenberger, Eric Schepers, Jun-Zhi Wei, Weiping Xie, Nasser Yalpani, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20170367349
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 7, 2016
    Publication date: December 28, 2017
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Publication number: 20170226228
    Abstract: The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
    Type: Application
    Filed: June 26, 2015
    Publication date: August 10, 2017
    Inventors: Gary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
  • Publication number: 20170003305
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Application
    Filed: September 19, 2016
    Publication date: January 5, 2017
    Applicant: CRIMSON U.S. ASSETS LLC
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Patent number: 9482677
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: November 1, 2016
    Assignee: SCIOS INC.
    Inventors: Ute Schellenberger, Eric E Niederkofler, Urban A Kieman, Randall W. Nelson, Jessica O'Rear