Patents by Inventor Jessica R. Spengler

Jessica R. Spengler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS REPLICON PARTICLES AND USE THEREOF
    Publication number: 20220023410
    Abstract: Crimean-Congo hemorrhagic fever (CCHF) virus replicon particles (VRP) are described. These VRP are capable of undergoing a single round of virus replication, but are unable to produce new particles or spread to neighboring cells due to the lack of the glycoprotein-encoding M genome segment. In some instances, the VRP contain one or more mutations in the viral ovarian tumor domain protease encoded by the L genome segment or heterologous antigens within its S genome segment. The VRP are shown to elicit a protective immune response against lethal CCHF virus challenge in an animal model.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 27, 2022
    Applicants: University of Georgia Research Foundation, Inc., THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Eric Bergeron, Scott D. Pegan, Stephen R. Welch, Florine E.M. Scholte, Christina F. Spiropoulou, Stuart T. Nichol, Jessica R. Spengler