Patents by Inventor Jessica Rachel MOLEK

Jessica Rachel MOLEK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for purifying antibodies
    Patent number: 11530238
    Abstract: The present invention relates to a method of purifying a recombinant polypeptide from Host Cell Proteins (HCP), the method comprising: (a) applying a solution comprising the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer comprising caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: December 20, 2022
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Andre C. Dumetz, Kent E. Goklen, Nicholas E. Levy, Jessica Rachel Molek, Andrew S. Thomson, Kenneth G. Yancey
  • METHODS FOR PURIFYING ANTIBODIES
    Publication number: 20210284686
    Abstract: The present invention relates to a method of purifying a recombinant polypeptide from Host Cell Proteins (HCP), the method comprising: (a) applying a solution comprising the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer comprising caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support.
    Type: Application
    Filed: September 6, 2017
    Publication date: September 16, 2021
    Inventors: Andre C. DUMETZ, Kent E GOKLEN, Nicolas E LEVY, Jessica Rachel MOLEK, Andrew S. THOMSON, Kenneth G. YANCY
  • METHODS FOR PURIFYING RECOMBINANT POLYPEPTIDES
    Publication number: 20210054051
    Abstract: A method of purifying a recombinant polypeptide from a Host Cell Protein (HCP), wherein the amino acid sequence of the recombinant polypeptide comprises a cathepsin L cleavage site is provided. The method includes: (a) applying a solution containing the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer containing caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support. A method of purifying an anti-OX40 antigen binding polypeptide from a Host Cell Protein (HCP) is also provided.
    Type: Application
    Filed: March 6, 2019
    Publication date: February 25, 2021
    Inventors: Andre DUMETZ, Kent E. GOKLEN, Nicholas E. LEVY, Jessica Rachel MOLEK, Andrew S. THOMSON, Kenneth G. YANCEY
  • METHOD OF PRODUCING A PROTEIN
    Publication number: 20150368292
    Abstract: The present invention relates to a method of producing a recombinant protein by harvesting a microbial cell broth and adding an amount of a flocculant to achieve an effective particle size distribution. The present invention also relates to a method of clarifying a microbial harvest by adding an amount of a flocculant to achieve an effective particle size distribution.
    Type: Application
    Filed: January 29, 2014
    Publication date: December 24, 2015
    Applicant: GLAXO GROUP LIMITED
    Inventors: Alex CHATEL, Michael HOARE, Peter KUMPALUME, Jessica Rachel MOLEK, Jason Michael RECK, Andrew David WEBER