Abstract: Nucleic acids are described that encode for triggering receptor expressed on myeloid cells 2 (TREM2) and that can be used in expression constructs, vectors and gene therapies. Also described are methods of using the same for the treatment of TREM2-associated diseases and disorders, especially neurological diseases such as Alzheimer's Disease (AD), Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) or Nasu-Hakola Disease (NHD).

Abstract: Embodiments of the disclosure relate to an optical fiber cable. The optical fiber cable includes a cable jacket having an inner surface and an outer surface in which the inner surface defines a central bore along a longitudinal axis of the optical fiber cable and the outer surface defines the outermost extent of the cable. The optical fiber cable also includes at least one access feature disposed in the cable jacket between the inner surface and the outer surface. Further included are a first plurality of optical fiber bundles. Each optical fiber bundle includes a second plurality of optical fiber ribbons that has a third plurality of optical fibers arranged in a planar configuration. The optical fiber cable bends uniformly in all directions transverse to the longitudinal axis of the optical fiber cable.

Abstract: Embodiments of the disclosure relate to an optical fiber cable. The optical fiber cable includes a cable jacket having an inner surface and an outer surface in which the inner surface defines a central bore along a longitudinal axis of the optical fiber cable and the outer surface defines the outermost extent of the cable. The optical fiber cable also includes at least one access feature disposed in the cable jacket between the inner surface and the outer surface. Further included are a first plurality of optical fiber bundles. Each optical fiber bundle includes a second plurality of optical fiber ribbons that has a third plurality of optical fibers arranged in a planar configuration. The optical fiber cable bends uniformly in all directions transverse to the longitudinal axis of the optical fiber cable.

Abstract: Embodiments of the disclosure relate to an optical fiber cable. The optical fiber cable includes a cable jacket having an inner surface and an outer surface in which the inner surface defines a central bore along a longitudinal axis of the optical fiber cable and the outer surface defines the outermost extent of the cable. The optical fiber cable also includes at least one access feature disposed in the cable jacket between the inner surface and the outer surface. Further included are a first plurality of optical fiber bundles. Each optical fiber bundle includes a second plurality of optical fiber ribbons that has a third plurality of optical fibers arranged in a planar configuration. The optical fiber cable bends uniformly in all directions transverse to the longitudinal axis of the optical fiber cable.

Abstract: A steel coil weighing apparatus includes a base having a structure capable of supporting the weighing apparatus and an article to be weighed and having a base portion capable of contact with a load cell, a platform positioned above the base and having a platform portion capable of contact with a load cell, at least one load cell positioned between the base portion and the platform portion and capable of providing a signal corresponding to the weight of an article to be weighed, and at least one guide capable of aligning the base and the platform.

Abstract: A steel coil weighing apparatus includes a base having a structure capable of supporting the weighing apparatus and an article to be weighed and having a base portion capable of contact with a load cell, a platform positioned above the base and having a platform portion capable of contact with a load cell, at least one load cell positioned between the base portion and the platform portion and capable of providing a signal corresponding to the weight of an article to be weighed, and at least one guide capable of aligning the base and the platform.

Abstract: The invention provides a translucent, water-insoluble hydrogel composition and methods of making it. The hydrogel composition comprises a polyvinyl alcohol polymer and a complexing agent which are physically crosslinked to form a semi-crystalline polyvinyl alcohol-complexing agent polymer complex. This is achieved by:(i) combining a polyvinyl alcohol polymer with a suitable aprotic solvent;(ii) Adding a complexing agent to (i) to form a water soluble complex with the polyvinyl alcohol polymer; and(iii) Allowing the polyvinyl alcohol polymer and the complexing agent to form a water-insoluble, semi-crystalline structure.The formation of the semi-crystalline structure is assisted by freezing the polyvinyl alcohol/complexing agent/polar aprotic solvent mixture.