Abstract: An electrode pad with a defibrillation circuit and a separate ECG tracing circuit. The electrode pad includes a foam base layer, first and second conductive layers, and a hydrogel layer. The foam base layer has a first side and the first conductive layer is centrally located on the base layer. The first conductive layer has a first circuit configured to provide a defibrillation current. The second conductive layer extends at least partially around the first conductive layer on the first side of the base layer. The second conductive layer has a separate second circuit configured to receive an electrical signal. The hydrogel layer covers the first and second conductive layers on the first side of the base layer. The electrode pad additionally includes an electrical connector attached to the first and second conductive layers. The electrical connector is configured for providing a voltage to the first and second conductive layers.

Abstract: A surgical suction system. The surgical suction system includes a large bore Yankauer suction device having a distal tip with a first diameter, and a proximal end with exterior hose barbs and a second diameter. The second diameter is greater than the first diameter such that a channel extending through the large bore Yankauer suction device may have an increasing diameter from the distal tip to the proximal end. The surgical system also includes cannulated tubing having a distal end and a proximal end, the distal end configured to mate with the exterior hose barbs of the Yankauer suction device. The surgical system further includes an adapter having a distal end with exterior hose barbs and a proximal end. The exterior hose barbs configured to mate with the proximal end of the cannulated tubing. The proximal end of the adapter is configured to connect to a port to a canister, wall vacuum, or other biological material collection device.

Abstract: One aspect of the invention provides a method of producing a heterogeneous filament. The method includes applying pressure to a plurality of filament components to move the filament components into a common outlet channel. Another aspect of the invention provides a method of fabricating a scaffold. The method includes producing a plurality of filaments according to the methods described herein. Another aspect of the invention provides a scaffold produced according to the methods described herein. Another aspect of the invention provides a heterogeneous filament including a plurality of adjacent filament components. Another aspect of the invention provides a method of producing a droplet. The method includes: positioning a printing tip in proximity to a cross-linking liquid; applying pressure to one or more liquids to produce a droplet extending beyond outside of the printing tip; and contacting the droplet with the cross-linking liquid, thereby producing a droplet.

Abstract: Thin pnc-Si membranes operate as high-flow-rate EOPs at low applied voltages. In at least some instances, this may be due to the small electrical resistance presented by the membrane and high electric fields across the molecularly thin membrane. The normalized flow rates of some pnc-Si EOPs may be 20 times to several orders of magnitude higher than other low-voltage EOPs.

Abstract: The present invention relates to microfluidic systems and methods for monitoring or detecting a change in a characteristic of an input substance. Specifically, the invention relates to a model for in vitro pharmacokinetic study and other pharmaceutical applications, as well as other uses including computing, sensing, filtration, detoxification, production of chemicals and biomolecules, testing cell/tissue behavior, toxicology, drug metabolism, drug screening, drug discovery, and implantation into a subject. The present invention also relates to systems and methods of a microplasm functionalized surface patterning of a substrate. The present invention represents an improvement over existing plasma systems used to modify the surface of a substrate, as the present invention creates surface patterning without the use of a mask, stamp or a chemical treatment.

Abstract: Disclosed is a device for co-culturing two or more populations of cells using ultrathin, porous membranes positioned between cell culture chambers. Multiple chamber devices and uses thereof are described, including the formation of in vitro tissue models for studying drug delivery, cell-cell interactions, and the activity of low abundance molecular species.

Abstract: The invention provides methods (also referred to herein as a “screening assays”) for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, small molecules or other drugs) capable of modulating tolerance. In one embodiment, the invention provides methods for identifying a tolerance modulatory compound, comprising, e.g., contacting a T cell with a stimulating agent and a test compound and assaying for expression or activity of at least one T regulatory (Treg) marker and at least one T effector (Teff) marker.