Abstract: A portable cone-shaped single container holder that is lightweight and holds sports beverage coolers, including half gallon sports beverage coolers, and other containers. The device can be placed on the flat floor, including the flat floor of a vehicle. Containers are placed in the open interior holding space or compartment. Even when free standing, the device's stable structure holds a container in the upright position. The container holder reduces spilling and damage to containers and their contents caused when bumped into or when the motion of the vehicle during reasonable driving conditions would otherwise cause the container to tip over. The container holder does not require additional balancing, weights, internal adjustments, or vehicle restraints. The container holder allows room for vehicle passengers feet, and allows for easy portability and travel.

Abstract: The invention relates to compounds of formula (I) wherein X1, X2, R1 to R4, m, and n have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds, the preparation of such compounds as well as the use as medicaments.

Abstract: The invention relates to compounds of formula (I) wherein X1, X2, R1 to R4, m, n have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.