Patents by Inventor JESSIE M. ENGLISH

JESSIE M. ENGLISH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using anti-lap antibodies
    Patent number: 11230601
    Abstract: Provided herein are antibodies which bind to latency-associated peptide (LAP) of TGF-?1 and are characterized by particular functional features, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: January 25, 2022
    Assignee: Tilos Therapeutics, Inc.
    Inventors: Barbara S. Fox, Randall Burton, Stavros Kopsiaftis, Xiufeng Song, Patricia Rao, Kenneth J. Simon, Jessie M. English
  • ANTI-LAP ANTIBODY VARIANTS AND USES THEREOF
    Publication number: 20220017612
    Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Application
    Filed: September 2, 2021
    Publication date: January 20, 2022
    Inventors: Randall Burton, Jessie M. English, Barbara S. Fox, Stavros Kopsiaftis, Yacob Gomez Llorente, Renee Moore, Patricia Rao, Giovanna Scapin, Kenneth J. Simon, Haihong Zhou
  • Anti-lap antibody variants
    Patent number: 11130802
    Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: September 28, 2021
    Assignees: Tilos Therapeutics, Inc., Merck Sharp & Dohme Corp.
    Inventors: Randall Burton, Jessie M. English, Barbara S. Fox, Stavros Kopsiaftis, Renee Moore, Patricia Rao, Kenneth J. Simon
  • Compositions and methods for identification, assessment, prevention, and treatment of cancer using NFS1 biomarkers and modulators
    Patent number: 10947596
    Abstract: The present invention is based, in part, on the identification, of novel mitochondrial iron-sulfur (Fe—S) cluster biosynthesis pathway biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating cancer.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: March 16, 2021
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Mark Bittinger, Jessie M. English, Kwok-Kin Wong, Sima Zacharek
  • ANTI-LAP ANTIBODY VARIANTS AND USES THEREOF
    Publication number: 20200140530
    Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Application
    Filed: October 9, 2019
    Publication date: May 7, 2020
    Inventors: Randall BURTON, Jessie M. ENGLISH, Barbara S. FOX, Stavros KOPSIAFTIS, Yacob GOMEZ LLORENTE, Renee MOORE, Patricia RAO, Giovanna SCAPIN, Kenneth J. SIMON, Haihong ZHOU
  • ANTI-LAP ANTIBODIES AND USES THEREOF
    Publication number: 20190144549
    Abstract: Provided herein are antibodies which bind to latency-associated peptide (LAP) of TGF-?1 and are characterized by particular functional features, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
    Type: Application
    Filed: October 10, 2018
    Publication date: May 16, 2019
    Inventors: Barbara S. FOX, Randall BURTON, Stavros KOPSIAFTIS, Xiufeng SONG, Patricia RAO, Kenneth J. SIMON, Jessie M. ENGLISH
  • COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF CANCER USING NFS1 BIOMARKERS AND MODULATORS
    Publication number: 20170051358
    Abstract: The present invention is based, in part, on the identification, of novel mitochondrial iron-sulfur (Fe—S) cluster biosynthesis pathway biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating cancer.
    Type: Application
    Filed: May 6, 2015
    Publication date: February 23, 2017
    Inventors: Mark Bittinger, Jessie M. English, Kwok-Kin Wong, Sima Zacharek
  • METHODS FOR CRYSTALLIZING ERK2 POLYPEPTIDES
    Publication number: 20100190231
    Abstract: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
    Type: Application
    Filed: April 5, 2010
    Publication date: July 29, 2010
    Inventors: JESSIE M. ENGLISH, Thierry Oliver Fischmann, Thomas Hesson, Alan William Hruza, Weihong Jin, Paul Reichert, Catherine Smith, Shahriar Shane Taremi