Abstract: Pharmaceutical composition comprising growth-hormone releasing peptide 6 (GHRP-6), tartrate buffer at pH 5.0-6.0, and trehalose as stabilizing agent, as well as the use of said composition for the manufacture of a medicament. The invention also provides a kit of parts comprising said pharmaceutical composition and a method of treatment of an individual in need thereof, which entails the administration of a therapeutically effective amount of the pharmaceutical composition comprising of GHRP-6, tartrate buffer at pH 5.0-6.0 and trehalose.

Abstract: An elevator system includes a guide rail, an elevator car, a safety brake actuator and a safety brake. The safety brake actuator and the safety brake are mounted to the elevator car to move along the guide rail with the elevator car in use. The safety brake actuator includes an actuation mechanism configured in use to actuate the engagement of the safety brake against the guide rail. The safety brake actuator also includes a proximal surface, the safety brake actuator is mounted adjacent to the guide rail with the proximal surface facing the guide rail and spaced from the guide rail to define a clearance gap between the guide rail and the proximal surface of the safety brake actuator.

Abstract: A system for controlling temperature of a body (6) comprising a DBD actuator (9) connectable to a power source to produce an ionic wind on the body; a control unit (8) to select an initial configuration and to control the power source (5) depending on a temperature difference (?T) between an input temperature (Ti) and a target temperature (Tta) on the body (6), wherein the initial configuration comprises the following constructive parameters of the DBD actuator: number, shape, geometry, relative position of electrodes (d), dielectric material, dielectric thickness (e), wherein the initial configuration further comprises the following setting parameters to be set in the power source (5): a frequency value (f), an amplitude value (V), a waveform signal and a duty cycle, wherein the control unit (8) adjusts the initial configuration by modifying any of the setting parameters to control the heat transferred to the surface of the body.

Abstract: The invention relates to neurodegenerative disorders, and in particular to novel peptides, peptidomimetics, compositions, therapies and methods for treating such conditions, for example Alzheimer's disease.

Abstract: Disclosed is a method of making a part, comprising: forming the part via an additive manufacturing process, wherein the additive manufacturing process comprises layering, melting, and solidifying a metal alloy based on a three dimensional numerical model, wherein the formed part comprises a microstructure, wherein the microstructure comprises an average columnar grain length; and heat treating the formed part, wherein heat treating comprises heating to between 750° C. and 1200° C. for a time between 0.5 hours and 10 hours and then cooling the formed part below 750° C., wherein after heat treating, the formed part has an average columnar grain length of about 400 micrometers to about 1000 micrometers, as measured using electron backscattered diffraction.

Abstract: An elevator system includes a guide rail, an elevator car, a safety brake actuator and a safety brake. The safety brake actuator and the safety brake are mounted to the elevator car to move along the guide rail with the elevator car in use. The safety brake actuator includes an actuation mechanism configured in use to actuate the engagement of the safety brake against the guide rail. The safety brake actuator also includes a proximal surface, the safety brake actuator is mounted adjacent to the guide rail with the proximal surface facing the guide rail and spaced from the guide rail to define a clearance gap between the guide rail and the proximal surface of the safety brake actuator.

Abstract: A gearcase seal assembly includes an inboard seal body and an outboard seal body both extending about and along a center axis between respective interior and exterior portions. The inboard and outboard seal bodies include respective inboard and outboard pockets configured to receive first and second surfaces of a gearcase of an axle assembly, respectively. The interior portions of the inboard and outboard seal bodies include respective gutters configured to direct fluid away from the first and second surfaces of the gearcase, respectively. The exterior portion of the inboard seal body includes plural fingers disposed outside of the inboard pocket and extending in one or more directions away from the inboard pocket. The exterior portion of the outboard seal body includes plural other fingers disposed outside of the outboard pocket and extending in one or more directions away from the outboard pocket.

Abstract: A hybrid faucet assembly configured to operate in a touchless, hands-free automatic mode and a manual mode comprises a faucet body; a faucet spout; a first manual flow control valve connected to a cold water source; a second manual flow control valve connected to a hot water source; an electromechanical valve connected to a cold water source or to both a cold water source and a hot water source; a flow director; a controller; and an activator device. The hybrid faucet assembly may comprise an override mechanism to disable an automatic mode during operation of a manual mode.

Abstract: The present description relates to a 2D visual code based on the superposition of pure flat waves framed in black, designed to be read at long distances, with different types of degradation (noise, blurring or movement) and in adverse lighting conditions. To this end, the information carrying elements are waves that are distributed over the whole image. The combination of waves with different directions, frequencies, amplitudes and phases permits generating a high number of configurations that may be decoded in a robust and efficient manner.

Abstract: A method for reducing instability of a nozzle meniscus of a droplet deposition apparatus. The method includes the steps of receiving first and second data blocks for respective first and second line pixels, receiving a data set of forbidden pixel periods, determining a first jitter delay value based on the forbidden pixel periods, generating first and second print data based on the first and second data blocks, the first print data defining a first holding period and one or more drive pulses and the second print data defining one or more drive pulses; wherein the first and second print data generate first and second actuating element signals that cause an actuating element to eject at least one droplet from a nozzle, wherein the first jitter delay value adjusts a first pixel period, defined by the drive pulses, to fall outside of the forbidden pixel periods to reduce nozzle meniscus instability.

Abstract: The invention relates to a fodder distributor formed by: a propelled carriage comprising a first shredding surface in the rear part, in the direction of travel, with first propulsion means, and a second surface in the front part, for feeding bales to the first surface; a first mechanism for shredding parallelepiped bales, with a shaft having a first end connected to rotation means and longitudinal blades projecting radially from the shaft; second propulsion means on the second surface; and respective panels for providing additional bale support, which are positioned horizontally adjacent to the second surface and have means for moving the bales to said surface.

Abstract: A hybrid faucet assembly configured to operate in a touchless, hands-free automatic mode and a manual mode comprises a faucet body; a faucet spout; a first manual flow control valve connected to a cold water source; a second manual flow control valve connected to a hot water source; an electromechanical valve connected to a cold water source or to both a cold water source and a hot water source; a flow director; a controller; and an activator device. The hybrid faucet assembly may comprise an override mechanism to disable an automatic mode during operation of a manual mode.

Abstract: Techniques, methods and/or apparatuses are disclosed that enable detection of an operating system of a host. Through the disclosed techniques, an operating system detection model, which may be a form of a machine learning model, may be trained to detect operating system. The operating system detection model may be provided to an operating system detector to detect operating system of a host utilizing transport layer probes without the need to have credentialed access to the host.

Abstract: A turbine engine has: a compressor; a combustor; a turbine, a gas flowpath passing consecutively through the compressor, combustor, and turbine; and inlet member along the gas flowpath upstream of the compressor. The inlet member includes the unitarily-formed single piece combination of: a three dimensional (3D) lattice portion; and a nose cap body surrounding the lattice portion.

Abstract: The invention is based on a method of modulating the activation or inhibition of Mixed lineage kinase domain-like (MLKL) protein, or a MLKL variant protein, via modulating the intramolecular interaction between the C-terminal helix (Hc) of the psK domain and a hydrophobic groove in the MLKL protein. The invention provides methods and compounds for to selectively target the herein firstly disclosed intramolecular interaction of MLKL protein. Based on the herein disclosed essential intramolecular rearrangement of MLKL, the invention provides small molecules capable of specifically inhibiting mouse or human MLKL. The invention provides uses, including medical applications such as treatments, of MLKL driven conditions including necroptosis, cell trafficking, pathological immune responses and/or inflammation.

Abstract: The present description relates to a 2D visual code based on the superposition of pure flat waves framed in black, designed to be read at long distances, with different types of degradation (noise, blurring or movement) and in adverse lighting conditions. To this end, the information carrying elements are waves that are distributed over the whole image. The combination of waves with different directions, frequencies, amplitudes and phases permits generating a high number of configurations that may be decoded in a robust and efficient manner.

Abstract: A droplet deposition apparatus (1) comprising: a first head module (101A, 101B, 102A) and a second head module (101B, 102A, 102B) arranged in at least partially overlapping relationship, each head module having a plurality of nozzles in at least one nozzle array (A1, B1); and a storage (200) configured to store a table of determined best aligned nozzle pairs in an overlap region and corresponding skew angles (?i) of at least one of the head modules relative to a datum of the droplet deposition apparatus and/or a corresponding positional offset of the second head module relative to the first head module; wherein, in the overlap region, nozzles of the first head module are arranged at a first nozzle pitch (P2) and nozzles of the second head module are arranged at a second nozzle itch (P3).

Abstract: The present invention relates to the use of grape skin or a composition comprising it as prebiotic for increasing the intestinal levels and/or activity of butyrate-producing bacteria, such as Faecalibacterium prausnitzii, F. prausnitzii phylogroup I (PHGI), F. prausnitzii phylogroup II (PHGII), Roseburia hominis and Subdoligranulum variabile, in a subject. More specifically it refers to grape skin or a composition comprising it for use in a method of treating intestinal dysbiosis in a subject, wherein intestinal dysbiosis is characterized by a decrease of butyrate-producing bacteria levels and/or activity. In addition, it pertains to grape skin or a composition comprising it for use in a method of treating an inflammatory or non-inflammatory intestinal disease in a subject having reduced levels and/or reduced activity of butyrate-producing bacteria.

Abstract: A turbine engine has: a compressor; a combustor; a turbine, a gas flowpath passing consecutively through the compressor, combustor, and turbine; and inlet member along the gas flowpath upstream of the compressor. The inlet member includes the unitarily-formed single piece combination of: a three dimensional (3D) lattice portion; and a nose cap body surrounding the lattice portion.