Patents by Inventor Jesus Ching
Jesus Ching has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240359180Abstract: The present disclosure provides various systems, diagnostic devices, and methods for nucleic acid analysis. The systems, devices, and methods allow for the analysis of nucleic acids, in a sample, via programmable nuclease-based assays. Provided are systems comprising an instrument and a cartridge allowing for point of care use. The systems, devices, and methods described herein can be configured for multiplexed detection of nucleic acids in a single sample.Type: ApplicationFiled: December 15, 2023Publication date: October 31, 2024Inventors: Timothy James PATNO, Phillip You Fai LEE, Benjamin Andrew BLIZARD, Xin MIAO, Jacob LESINSKI, Ryan A. BROWN, Daniel Thomas DRZAL, Sarah Jane SHAPIRO, Joshua BAIK, Janice Sha CHEN, James Paul BROUGHTON, Clare Louise FASCHING, Jesus CHING, Sonal JAIN, Deepika VERMA, Matthew VEROSLOFF, Devin SPRATT, Nicholas John FANTIN
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Publication number: 20240327810Abstract: The present disclosure provides compositions of effector proteins. The compositions may comprise engineered guide nucleic acids. Also disclosed are the methods and systems for detecting and modifying target nucleic acids using the same. The compositions may provide nucleic acid modification and/or detection at relatively high temperatures.Type: ApplicationFiled: November 3, 2023Publication date: October 3, 2024Inventors: James Paul BROUGHTON, Janice Sha Chen, Jesus Ching, Clare Louise Fasching, Lucas Benjamin Harrington, Lior Kreindler, Bridget Ann Paine Mckay, David Paez-Espino, Benjamin Julius Rauch, Matthew Verosloff, William Douglass Wright
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Publication number: 20240326048Abstract: The present disclosure provides various diagnostic devices. Devices can comprising a sample interface configured to receive a sample that may comprise at least one sequence of interest; a channel in fluid communication with the sample interface and a detection chamber, said channel comprising one or more movable mechanisms to separate the sample into a plurality of droplets, wherein said detection chamber is configured to receive and contact the plurality of droplets with at least one programmable nuclease probe disposed on a surface of said detection chamber, and wherein said at least one programmable nuclease probe may comprise a guide nucleic acid complexed with a programmable nuclease; and a plurality of sensors that determine a presence of said at least one sequence of interest by detecting a signal produced upon cleavage of a target nucleic acid region of said at least one sequence of interest by said at least one programmable nuclease probe.Type: ApplicationFiled: November 22, 2022Publication date: October 3, 2024Inventors: Clare Louise FASCHING, Matthew VEROSLOFF, Jesus CHING, James Paul BROUGHTON, Maria-Nefeli TSALOGLOU, Phillip You Fai LEE, Timothy James PATNO, Janice Sha CHEN, Sarah Jane SHAPIRO, James Raymond CORDOVA, Brian J. EASTMAN, Donald Allan LOWMILLER, Lior KREINDLER, Daniel Thomas DRZAL, Devin SPRATT, Jacob LESINSKI, Joshua BAIK, Rachel Nouha DERANEY, Sonal JAIN, Sophia HUBBELL, Carley Gelenter HENDRIKS
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Publication number: 20240294970Abstract: Described herein are methods, devices, and compositions for immobilization of biomolecules in diagnostic assays onto a surface. The methods, devices, and compositions may utilize or comprise a plurality of different non-naturally occurring guide nucleic acids. Each of the different non-naturally occurring guide nucleic acids may be immobilized to a surface at a known location identified with the particular non-naturally occurring guide nucleic acid, Alternatively, or in combination, a plurality of programmable nucleases may be immobilized to the surface at each of the known locations. Optionally, the methods, devices, and compositions may utilize or comprise a plurality of reporters immobilized to the surface in proximity to each of the different non-naturally occurring guide nucleic acids and/or programmable nucleases at each of the known locations.Type: ApplicationFiled: June 13, 2023Publication date: September 5, 2024Inventors: Jesus CHING, James Paul BROUGHTON, Janice Sha CHEN, Sarah Jane SHAPIRO, Elizabeth Mae HAWKINS, Sonal JAIN, Lior KREINDLER, Sophia HUBBELL
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Publication number: 20240209421Abstract: The present disclosure provides single-buffer systems that enable efficient and rapid amplification and programmable nuclease enzyme mediated reactions. The single-buffer systems and reagent compositions therein may be used for assaying for a nucleic acid sequence from a sample.Type: ApplicationFiled: June 13, 2023Publication date: June 27, 2024Inventors: Janice Sha CHEN, Carley Gelenter HENDRIKS, Clare Louise FASCHING, Xin MIAO, Nazmiye Emel ALPAY, James Paul BROUGHTON, Elizabeth M. HAWKINS, Matthew S. VEROSLOFF, Sophia HUBBELL, Sarah Jane SHAPIRO, Lior KREINDLER, Jesus CHING
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Publication number: 20240139728Abstract: The application provides devices, kits and methods for a streamlined lateral flow assay for sample preparation, optional amplification, and detection of a target nucleic acid using programmable nuclease reagents.Type: ApplicationFiled: November 15, 2022Publication date: May 2, 2024Inventors: Maria-Nefeli TSALOGLOU, Janice Sha CHEN, James Paul BROUGHTON, Daniel Thomas DRZAL, Sarah Jane SHAPIRO, Clare Louise FASCHING, Carley Gelenter HENDRIKS, Jesus CHING, Sonal JAIN
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Publication number: 20230332253Abstract: Described herein, in certain embodiments, are methods of assaying for a segment of a coronavirus target nucleic acid in a sample. In some embodiments, the target nucleic acid is from a gene of SARS-CoV-2, or a variant thereof. In some embodiments, methods described herein comprise a) contacting the sample to: i) a detector nucleic acid; and ii) a composition comprising a programmable nuclease and a non-naturally occurring guide nucleic acid, and b) assaying for a change in a signal, wherein the change in the signal is produced by cleavage of the detector nucleic acid by the programmable nuclease. Also provided herein are devices for performing the methods of assaying for a segment of a coronavirus target nucleic acid described herein.Type: ApplicationFiled: August 5, 2022Publication date: October 19, 2023Inventors: Maria-Nefeli TSALOGLOU, Clare FASCHING, Jesus CHING, Janice Sha CHEN, James Paul BROUGHTON, Daniel Thomas DRZAL, Sarah Jane SHAPIRO
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Publication number: 20230159992Abstract: Disclosed herein are systems and methods for providing a high-throughput DETECTR assay in a single chamber. The single chamber may be one well of a microplate, and multiple assays may be conducted in a staggered fashion in separate chambers. The methods described herein implement a process including lysing a sample, isolating nucleic acid molecules, eluting the nucleic acid molecules, amplifying the nucleic acid molecules, and detecting a presence of a target nucleic acid.Type: ApplicationFiled: January 17, 2023Publication date: May 25, 2023Inventors: Timothy James PATNO, Jesus CHING, James Paul BROUGHTON, Xin MIAO, Janice Sha CHEN, Clare Louise FASCHING, Alexander HIRSCHI, Raymond Weibang MEI, Wesley Wendell ADDISON, II, Nazmiye Emel ALPAY, Farzaneh TONDNEVIS, Sara ANSALONI, Deepika VERMA
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Publication number: 20220186208Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: ApplicationFiled: October 22, 2021Publication date: June 16, 2022Inventors: David D. SWENSON, Gregory C. LONEY, Valeria REVILLA, Adrienne C. LAM, Helen HUANG, Colin KELLY, Victor BRIONES, Brian CIOPYK, Boris ANDREYEV, Adam DE LA ZERDA, Keith MORAVICK, Jesus CHING, Jennifer ALBRECHT, Ryan CENA, Edward BIBA, Jonathan HONG
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Patent number: 11273443Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: GrantFiled: October 14, 2020Date of Patent: March 15, 2022Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
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Publication number: 20220055032Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: October 22, 2021Publication date: February 24, 2022Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20220033884Abstract: The present disclosure provides kits, methods and systems for identifying spinal muscular atrophy (SMA) in a subject or identifying the subject as a carrier of SMA.Type: ApplicationFiled: July 8, 2021Publication date: February 3, 2022Inventors: Robert Daber, Roger Schaller, Jesus Ching
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Patent number: 11193119Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: GrantFiled: November 9, 2018Date of Patent: December 7, 2021Assignee: Visby Medical, Inc.Inventors: David D. Swenson, Gregory C. Loney, Valeria Revilla, Adrienne C. Lam, Helen Huang, Colin Kelly, Victor Briones, Brian Ciopyk, Boris Andreyev, Adam De La Zerda, Keith Moravick, Jesus Ching, Jennifer Albrecht, Ryan Cena, Edward Biba, Jonathan Hong
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Publication number: 20210354131Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: September 11, 2020Publication date: November 18, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20210354132Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: October 14, 2020Publication date: November 18, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Patent number: 11167285Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: GrantFiled: August 23, 2018Date of Patent: November 9, 2021Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
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Publication number: 20210331159Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: August 23, 2018Publication date: October 28, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20210039097Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: October 14, 2020Publication date: February 11, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20200406257Abstract: A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.Type: ApplicationFiled: September 16, 2020Publication date: December 31, 2020Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Rajinder K. BHATIA, Victor BRIONES, Phoebe CAO, Jesus CHING, Brian CIOPYK, Adam DE LA ZERDA, Jonathan H. HONG, Helen HUANG, Colin KELLY, Adrienne C. LAM, Gregory C. LONEY, Danielle MCSHEERY, Keith E. MORAVICK, Valeria REVILLA, Shaunak ROY, David D. SWENSON
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Publication number: 20200406256Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: September 11, 2020Publication date: December 31, 2020Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY