Patents by Inventor Jesus E. Gonzalez

Jesus E. Gonzalez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF USING SELECTIVE DELIVERY MOLECULES
    Publication number: 20250269069
    Abstract: Provided herein, in part, are selective delivery molecules their methods of use in the detection of cancer tissue and surgical excision of said cancer tissue.
    Type: Application
    Filed: October 8, 2021
    Publication date: August 28, 2025
    Inventors: Jesus E. Gonzalez, Steven Chen, Alec Harootunian, Phillip Poonka
  • SELECTIVE DELIVERY OF THERAPEUTIC AND IMAGING AGENTS
    Publication number: 20220347306
    Abstract: Described herein are methods and compositions for the targeted delivery of selective delivery molecule therapeutic agents and imaging agents.
    Type: Application
    Filed: April 16, 2019
    Publication date: November 3, 2022
    Inventors: Jesus E. GONZALEZ, Junjie LIU, Marcel MIAMPAMBA, Ning ZOU, Andrew GALE
  • Ratiometric fluorescence imaging methods
    Patent number: 11293868
    Abstract: Disclosed herein are ratiometric fluorescence imaging reagents, and image processing methods for using fluorescence ratio and intensity thresholds to detect and visualize regions of biological activity in biological specimens with improved accuracy.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 5, 2022
    Assignee: Avelas Biosciences, Inc.
    Inventors: Alec Harootunian, Jesus E. Gonzalez
  • COMPOSITIONS AND METHODS FOR THE SELECTIVE DELIVERY OF THERAPEUTIC AND IMAGING AGENTS
    Publication number: 20210079039
    Abstract: Described herein are methods and compositions for the targeted delivery of therapeutic agents and imaging agents.
    Type: Application
    Filed: April 16, 2019
    Publication date: March 18, 2021
    Inventors: Jesus E. GONZALEZ, Junjie LIU, Marcel MIAMPAMBA, Giuseppe DELLO IACANO, Ning ZOU, Andrew GALE
  • RATIOMETRIC FLUORESCENCE IMAGING METHODS
    Publication number: 20200150041
    Abstract: Disclosed herein are ratiometric fluorescence imaging reagents, and image processing methods for using fluorescence ratio and intensity thresholds to detect and visualize regions of biological activity in biological specimens with improved accuracy.
    Type: Application
    Filed: April 5, 2018
    Publication date: May 14, 2020
    Inventors: Alec HAROOTUNIAN, Jesus E. GONZALEZ
  • Quinazolines useful as modulators of ion channels
    Publication number: 20040248890
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 3, 2004
    Publication date: December 9, 2004
    Inventors: Jesus E. Gonzalez, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmermann
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Publication number: 20040191757
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: February 2, 2004
    Publication date: September 30, 2004
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Publication number: 20040180426
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: February 2, 2004
    Publication date: September 16, 2004
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • Ion channel assay methods
    Publication number: 20040110123
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: July 14, 2003
    Publication date: June 10, 2004
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • Detection of transmembrane potentials by optical methods
    Publication number: 20040002123
    Abstract: Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems.
    Type: Application
    Filed: December 31, 2002
    Publication date: January 1, 2004
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Roger Y. Tsien, Jesus E. Gonzalez
  • Detection of transmembrane potentials by optical methods
    Publication number: 20030207248
    Abstract: Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems.
    Type: Application
    Filed: December 31, 2002
    Publication date: November 6, 2003
    Inventors: Roger Y. Tsien, Jesus E. Gonzalez
  • Detection of transmembrane potentials by optical methods
    Publication number: 20030129670
    Abstract: Methods and compositions are provided for determining the potential of a membrane.
    Type: Application
    Filed: December 31, 2002
    Publication date: July 10, 2003
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Roger Y. Tsien, Jesus E. Gonzalez
  • Detection of transmembrane potentials by optical methods
    Publication number: 20020164577
    Abstract: Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems.
    Type: Application
    Filed: September 28, 2001
    Publication date: November 7, 2002
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Roger Y. Tsien, Jesus E. Gonzalez
  • DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS
    Publication number: 20020137201
    Abstract: Methods and compositions are provided for determining the potential of a membrane.
    Type: Application
    Filed: August 20, 1999
    Publication date: September 26, 2002
    Inventors: TOGER Y. TSIEN, JESUS E. GONZALEZ
  • Ion channel assay methods
    Publication number: 20020045159
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: March 12, 2001
    Publication date: April 18, 2002
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Publication number: 20020028480
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: March 12, 2001
    Publication date: March 7, 2002
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • Multi-well plate and electrode assemblies for ion channel assays
    Publication number: 20020025573
    Abstract: Plate and electrode assemblies include configurations allowing for relatively uniform electric field production. The electrodes may comprise strips of conductive material plated onto the bottom surface of sample wells or they may comprise plate electrodes extending down into the well. In some embodiments, the electric field strength varies by less than about 10% from a mean field intensity over at least about 20% of the surface area of the bottom surface of a sample well.
    Type: Application
    Filed: March 12, 2001
    Publication date: February 28, 2002
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • Ion channel assay methods
    Publication number: 20020025568
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: March 12, 2001
    Publication date: February 28, 2002
    Inventors: Michael P. Maher, Jesus E. Gonzalez