Abstract: A skating training device with a V-shape frame that has a front end and two rear portions with handles. The front end includes a wheeled leg and the rear portions include rear legs that terminate with skating blade assemblies. A brake system includes actuating levers that transmit a force of predetermined magnitude to an elongated bar that is pivotally mounted to the blade assemblies and include a braking teethed plate mounted thereto so that predetermined movements of the actuating lever result in causing the teethed plate member to sink against the ice surface. Optionally, the blade assemblies can be replaced with wheel assemblies for land skating.

Abstract: Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane, as described by the Nernst equation, (b) introducing a second reagent which labels the first face or the second face of the membrane, which second reagent comprises a chromophore capable of undergoing energy transfer by either (i) donating excited state energy to the fluorescent ion, or (ii) accepting excited state energy from the fluorescent ion, (c) exposing the membrane to radiation; (d) measuring energy transfer between the fluorescent ion and the second reagent, and (e) relating the energy transfer to the membrane potential. Energy transfer is typically measured by fluorescence resonance energy transfer.

Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

Abstract: A security method (100) in a radio access network can include monitoring (102) (by either a base station controller or a mobile radio) for one or more abnormalities among CPU utilization, memory storage, memory read-write, malicious incoming or outgoing messages, and virus file names, notifying (104) of a specific abnormality detected, and receiving (108) access, conditional access or limited access based on the specific abnormality detected. The method can further include receiving updates (112) used for monitoring the abnormalities. The method can further include the optional step (106) of issuing a notification from a mobile radio to a base station controller if the specific abnormality is detected and suspending (110) one or more services based on the specific abnormality detected. The method can further include receiving (114) at the mobile radio an over the air programming instruction to suspend a specific service and alerting the mobile radio.

Abstract: A gate assembly with moving gate members with one pivoting end and a moving end. This moving end includes upper and lower tubular members that receive the ends of a protruding reinforcement member mounted to a housing for the locking hardware. The ends of the protruding reinforcement member extend internally a sufficient distance to enhance the structural integrity of the moving end. The reinforcement member readily aligns the housing with the tubular members of the moving end and provides a sturdy structure that is tamper proof. Through openings in the walls of the housing cooperate to permit the operation of the locking hardware.

Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: Described is a medium for the autologous culture of autologous human progenitor stem cells, which comprises: between 0.1 and 90 wt.-% autologous human serum; between 0.1 and 10,000 UI/ml heparin; between 0.1 and 10,000 UI/ml protamine; and a culture medium consisting of basic nutrients with or without glutamine, in a sufficient quantity to make up 100 wt.-%, which can be used to culture and expand autologous human progenitor stem cells. Compositions containing said cells can be implanted in the patient using an autologous cellular cardiomyoplasty method in order to create, regenerate and repair dysfunctional myocardial tissue.

Abstract: The invention relates to a recombinant DNA and polypeptide sequence of an immuno-dominant phage particle associated protein from Bartonella bacilliformis. The recombinant protein is easily produced permitting the conduct of more accurate and rapid diagnositic assays for the detection of B. bacilliformis infection with reduced reagent and equipment requirements over that required by currently available methods of diagnosis. The DNA and polypeptide sequence is also useful in vaccine preparations against B. bacilliformis.

Abstract: The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides arc for instance isolated polypeptides with at least 87% idcntity with SEQ ID: NO. 2 or SEQ ED: NO. 4. The invention also relates to nucleic acid sequences encoding these polypeptides. The invention also relates to processes for the racemisation of enantiomerically enriched hydantoin compounds and to processes for the preparation of enantiomarically enriched I)-or I-? amino acids.

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: In one exemplary aspect, an access system for a moveable vehicle having a longitudinal axis is disclosed. The access system includes an access device attached to the vehicle and movable between a stowed position and an access position. A bottom end of the access device is disposed at a first horizontal distance from the longitudinal axis in the stowed position and is disposed a second greater horizontal distance from the longitudinal axis in the access position. The access system also includes a biasing device associated with the access device and configured to apply a continuous biasing force to bias the access device toward the access position. An actuator device is associated with the access device and configured to apply a selective actuating force to the access device.

Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: A remanufactured laser printer toner cartridge incorporates a used doctor blade and/or a used wiper blade. The used doctor blade has been adapted and oriented to make contact with a developer roller or a magnetic roller along a previously unused portion of the doctor blade's metering surface to utilize a new fresh metering surface. The used wiper blade has been adapted and oriented to make contact with a photoconductive drum along a previously unused portion of the wiper blade's wiping surface to utilize a new fresh wiping surface. The invention extends the effective life of doctor blades and wiper blades by utilizing previously unused working surfaces. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not to be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.