Abstract: The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.

Abstract: The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.

Abstract: A method of welding a thermoplastic sheet, having a first side and a second side, into a cylinder, the method comprising the steps of folding the thermoplastic sheet into a cylinder such that the first side and the second side overlap, positioning the thermoplastic sheet in a cylinder tube having a longitudinal opening such that the overlapping portions of the first and second sides of the thermoplastic sheet are aligned with the longitudinal opening, and activating a heat welder so that a press of the heat welder moves into the longitudinal opening of the cylinder tube and presses the thermoplastic sheet against an opposing surface to weld the overlapping portions of the first and second sides.

Abstract: Method for culturing resistant vineyards that selects indigenous vines, with natural stock, the fertilizer for which comprises local grasses/weeds, without other nutrients, harvesting being in the autumn. Fermentation method that is based on pressed grapes, in 20-25% of the vats, the wild yeasts thereof being produced and, in initial states, 3.5-6% vol. alcohol being achieved, with subsequent topping-up every 7-15 days; the total added sugar undergoes stepwise fermentation. Three different yeasts are obtained: white yeast (1), slow-growth yeast (2) and yellow yeast (3). Said yeasts make it possible directly to obtain high-quality beverages, such as cider, beers, cognacs, rums, vodkas, etc., with products having an alcohol content of up to 60% vol./vol. Fermentation also takes place with highly concentrated solutions of sucrose, molasses, sugars resulting from starch hydrolysis, and various plant materials. The production of bread, pastries and quality derived products is facilitated.

Abstract: A method of welding a thermoplastic sheet, having a first side and a second side, into a cylinder, the method comprising the steps of folding the thermoplastic sheet into a cylinder such that the first side and the second side overlap, positioning the thermoplastic sheet in a cylinder tube having a longitudinal opening such that the overlapping portions of the first and second sides of the thermoplastic sheet are aligned with the longitudinal opening, and activating a heat welder so that a press of the heat welder moves into the longitudinal opening of the cylinder tube and presses the thermoplastic sheet against an opposing surface to weld the overlapping portions of the first and second sides.