Patents by Inventor Jesus Moreno
Jesus Moreno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124478Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, CS, R2, and R3 are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.Type: ApplicationFiled: November 23, 2021Publication date: April 18, 2024Inventors: Yongxin Han, Elisabeth Hennessy, Andrew J. Hoover, Jesus Moreno, David L. Sloman, Uma Swaminathan, Yingchun Ye
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Publication number: 20240076297Abstract: The present invention provides compounds of the structural Formula (I), and pharmaceutically acceptable salts thereof, wherein, are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.Type: ApplicationFiled: July 22, 2021Publication date: March 7, 2024Applicant: Merck Sharp & Dohme LLCInventors: Amjad Ali, Jared N. Cumming, Manuel De Lera Ruiz, Duane DeMong, Thomas H. Graham, Elisabeth T. Hennessy, Joseph M. Kelly, Rongze Kuang, Michael Man-Chu Lo, Umar Faruk Mansoor, Jesus Moreno, Uma Swaminathan, Heping Wu, Yingchun Ye, Younong Yu
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Patent number: 11867383Abstract: Disclosed is an outdoor light fixture assembly having a housing and a lens module. The lens module is removable from the housing for servicing. The removable lens module includes a socket for one or more light sources and a lens. The outdoor light fixture further includes engagement structures for installing and removing the lens module from the housing without the use of tools.Type: GrantFiled: December 12, 2022Date of Patent: January 9, 2024Assignee: Hunter Industries, Inc.Inventors: Darrin I. Schmuckle, Jesus Moreno
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Publication number: 20230416266Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, CA, R1, R2a, and R2b are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.Type: ApplicationFiled: November 23, 2021Publication date: December 28, 2023Inventors: Yongxin Han, Elisabeth Hennessy, Andrew J. Hoover, Jesus Moreno, Uma Swaminathan
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Publication number: 20230322785Abstract: The present invention provides compounds of the structural Formula (I) and pharmaceutically acceptable salts thereof, wherein, are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.Type: ApplicationFiled: July 21, 2022Publication date: October 12, 2023Applicant: Merck Sharp & Dohme LLCInventors: Amjad Ali, Christopher W. Boyce, Jared N. Cumming, Duane DeMong, Thomas H. Graham, Subrahmanyam Gudipati, Andrew J. Hoover, Xianhai Huang, Rongze Kuang, Jae-Hun Kim, Joseph M. Kelly, Yeon-Hee Lim, Michael Man-Chu Lo, Jesus Moreno, Jing Su, Heping Wu, Dong Xiao, Younong Yu, Xiaohong Zhu
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Publication number: 20230181363Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: ApplicationFiled: February 13, 2023Publication date: June 15, 2023Applicant: Nova Eye, Inc.Inventors: Jesus Moreno, Philip Ian Prosser
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Publication number: 20230113724Abstract: Disclosed is an outdoor light fixture assembly having a housing and a lens module. The lens module is removable from the housing for servicing. The removable lens module includes a socket for one or more light sources and a lens. The outdoor light fixture further includes engagement structures for installing and removing the lens module from the housing without the use of tools.Type: ApplicationFiled: December 12, 2022Publication date: April 13, 2023Inventors: Darrin I. Schmuckle, Jesus Moreno
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Patent number: 11576816Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: GrantFiled: September 27, 2018Date of Patent: February 14, 2023Inventors: Jesus Moreno, Philip Ian Prosser
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Patent number: 11564835Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: GrantFiled: October 18, 2018Date of Patent: January 31, 2023Inventors: Jesus Moreno, Philip Prosser
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Patent number: 11525558Abstract: Disclosed is an outdoor light fixture assembly having a housing and a lens module. The lens module is removable from the housing for servicing. The removable lens module includes a socket for one or more light sources and a lens. The outdoor light fixture further includes engagement structures for installing and removing the lens module from the housing without the use of tools.Type: GrantFiled: October 14, 2020Date of Patent: December 13, 2022Assignee: Hunter Industries, Inc.Inventors: Darrin I. Schmuckle, Jesus Moreno
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Publication number: 20220113008Abstract: Disclosed is an outdoor light fixture assembly having a housing and a lens module. The lens module is removable from the housing for servicing. The removable lens module includes a socket for one or more light sources and a lens. The outdoor light fixture further includes engagement structures for installing and removing the lens module from the housing without the use of tools.Type: ApplicationFiled: October 14, 2020Publication date: April 14, 2022Inventors: Darrin I. Schmuckle, Jesus Moreno
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Publication number: 20220040184Abstract: In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): and, and pharmaceutically acceptable salts thereof, wherein, R1, n, R2, and R3 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.Type: ApplicationFiled: November 15, 2019Publication date: February 10, 2022Applicant: Merck Sharp Dohme Corp.Inventors: Zachary G. Brill, Amjad Ali, Jared Cumming, Duane DeMong, Qiaolin Deng, Gioconda V. Gallo-Etienne, Thomas H. Graham, Rongze Kuang, Matthew A. Larsen, Yeon-Hee Lim, Kun Liu, Umar Faruk Mansoor, Jesus Moreno, Brandon A. Vara, Huijun Wang, Yonglian Zhang
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Publication number: 20210128356Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: ApplicationFiled: October 18, 2018Publication date: May 6, 2021Inventors: Jesus Moreno, Philip Prosser
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Patent number: 10987247Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: GrantFiled: February 9, 2018Date of Patent: April 27, 2021Inventors: Jesus Moreno, Philip Ian Prosser
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Publication number: 20200246898Abstract: An apparatus for automation of weld seams machining of a wind turbine tower is provided. The apparatus includes an automated arm; a machining tool fixed to the automated arm; a compensator system fixed to the machining tool or being part of the automated arm; a joint visor that identifies and locates the weld seam; and a control unit to coordinate the movement of the machining tool with the compensator system and the joint visor. A method of performing a welded circular seam machining in a wind turbine tower with the apparatus is also provided.Type: ApplicationFiled: January 31, 2020Publication date: August 6, 2020Inventors: Jesus Moreno Catalan, Jose Fermin Gutierrez Fernandez, Pablo Unanua Hermoso de Mendoza
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Publication number: 20190110924Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: ApplicationFiled: February 9, 2018Publication date: April 18, 2019Inventors: Jesus Moreno, Philip Ian Prosser
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Publication number: 20190110925Abstract: In some embodiments, a microsurgical instrument includes a trocar having a rigid, hollow shaft formed with a lumen extending from a proximal end to a distal end of the shaft. The distal end of the shaft may be shaped for tissue penetration. The instrument may further include a composite microcannula slidably engaged with the trocar in the lumen. The microcannula includes a light guide and a flexible hollow tube having an outer diameter less than an inner diameter of the lumen in the trocar. Other embodiments include placing the microcannula in the lumen of the trocar, illuminating the end of the trocar by illuminating the end of the microcannula, advancing the trocar from a selected entry point on an eye into a selected structure in the eye, and extending the illuminated end of the microcannula from the trocar into the selected structure.Type: ApplicationFiled: September 27, 2018Publication date: April 18, 2019Inventors: Jesus Moreno, Philip Ian Prosser
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Publication number: 20110293562Abstract: The invention is related to the use of cardiotrophin-1 (CT-1) for the treatment of obesity and associated disorders: hyperglycaemias, insulin resistance, development of type 2 diabetes and dyslipemias and given its anorexigenic role, fat oxidation stimulant, hypoglycaemic, sensitizing agent of the action of insulin on a skeletal muscle level and inhibitor of the intestinal transport of glucose by enterocytes.Type: ApplicationFiled: February 10, 2010Publication date: December 1, 2011Applicant: PROYECTO DE BIOMEDICINA CIMA, S.L.Inventors: Jesus Maria Prieto Valtuena, Matilde Bustos De Abajo, Maria Jesus Moreno Aliaga
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Publication number: 20110248506Abstract: Assembly of components inside a large wind turbine, positioned between the upper section (3) of the tower (1) and under the nacelle. The components, which are transported pre-assembled to the site, are horizontal, circular platforms (6a and 6b), a vertical ladder (5) that goes through both platforms (6a and 6b) and a central structure (7) that joins and integrates the entire unit. The middle connection part (8) fitted onto the nacelle frame (4) allows the aforementioned unit to be coupled to the nacelle. The platforms (6a and 6b) house electrical devices for the drive train and the yaw system, as well as the lubrication and refrigeration system for the drive train. Once all the components have been assembled, they turn together with the nacelle while it rotates to face the wind.Type: ApplicationFiled: March 31, 2011Publication date: October 13, 2011Inventors: IGNACIO RUIZ URIEN, JESUS MORENO CATALAN, ALBERTO CALDERON PACHO, IBON PEREZ UNZURRUNZAGA, ALBERTO LINARES DE LA PUERTA
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Patent number: D946735Type: GrantFiled: June 12, 2019Date of Patent: March 22, 2022Inventors: Martin Jesus Moreno, Anthony Dominguez, Justin Hoffarth