Abstract: The present disclosure provides a lyophilized composition for use in a colorimetric nucleic acid amplification reaction. Also provided are processes for producing a lyophilized composition and methods for determining the presence of a target nucleic acid in a test sample or diagnosing or treating infection by a pathogen in a subject.

Abstract: A biological indicator for determining the efficacy of a sterilization process, and its methods of use. The biological indicator comprises a set of microbial spores, at least one sensor molecule, and a culture medium, the sensor molecule being capable of yielding an optically detectable signal when the sensor molecule is not in a inactivated state due to the sterilization process, and a different optically detectable signal when the sensor molecule is in a inactivated state after the sterilization process.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes include: obtaining one or more design criteria, a model of an object for which a physical structure is to be manufactured, and a set of eigenmodes from a modal analysis of the model of the object; extracting a proper subset of non-zero eigenmodes from the set of eigenmodes, wherein the proper subset of non-zero eigenmodes include at least three lowest valued, non-zero eigenmodes; combining data of the proper subset of non-zero eigenmodes to form a strain energy field for the model of the object; iteratively modifying a generatively designed shape of the model of the object using the strain energy field to drive changes to the generatively designed shape of the model; and providing the generatively designed shape of the model of the object.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures include: obtaining a design space for a modeled object and boundary conditions including a location where load is applied; checking whether, the boundary conditions include a specified direction for the load; assigning a direction for the load at the location when no specified direction is included; iteratively modifying a three dimensional shape in the design space in accordance with a physical response of the modeled object determined by a numerical simulation employing a linear analysis, where the iterative modification comprises determining a respective maximum sustainable load for each of two or more versions of the modified three dimensional shape; presenting to a user the two or more versions of the modeled object having different shapes; and receiving a user selection of one of the two or more versions of the modeled object.

Abstract: A conjugated diene copolymer has a covalent bond reversibly dissociated and added by heat, and has at least two peaks in each of curves of molecular weight distributions measured at 40° C. and 60° C. by gel permeation chromatography, wherein a change rate of the proportion of the area of the peak having the lowest molecular weight in measurement at 60° C. to the proportion of the area of the peak having the lowest molecular weight in measurement at 40° C.

Abstract: One embodiment of the present invention sets forth a technique for modeling assemblies using generative design techniques. The technique includes determining a portion of an assembly to model as a superelement and computing a mathematical model representing the superelement. The technique further includes eliminating one or more interior degrees of freedom from the mathematical model and computing a reduced stiffness matrix corresponding to the superelement by solving one or more equations associated with the mathematical model using an iterative sparse matrix solver.

Abstract: Disclosed herein are methods and systems for determining optimal primer sets for a multiplex assay, each of the optimal primer sets intended to amplify one or more targets. The method comprises obtaining amplification data from a plurality of preparatory assays. The amplification data describes at least the amplification of a first target of the one or more targets by a first primer set in a first preparatory assay, the amplification of the first target amplified by a second primer set in a second preparatory assay, the amplification of a second target of the one or more targets by the first primer set in a third preparatory assay, and the amplification of the second target by the second primer set in a fourth preparatory assay. The method further comprises determining a plurality of similarity metrics, each similarity metric being indicative of a degree of similarity between the amplification data produced by one of the plurality of preparatory assays compared to another one of the preparatory assays.

Abstract: An on-board toilet cubicle for an aircraft, including a front long side and a rear long side; a front short side and a rear short side, which are each connected at one end to the front long side and at their other end to the rear long side, the long sides and the short sides enclosing an interior of the toilet cubicle, and the front and the rear long sides each being wider than the front and the rear short sides; a toilet unit with a toilet opening; and an L-shaped door for accessing the on-board toilet cubicle, the L-shaped door having one door leg in the front long side and one door leg in the front short side, the toilet unit arranged adjacent to the rear long side, and the door leg in the front long side being wider than the door leg in the front short side.

Abstract: A lighting assembly for a vehicle has a light source accommodated in a housing. The light source is configured to emit light. The lighting assembly has an outer lens coupled to the housing. At least a portion of the outer lens is positioned to receive light emitted from the light source and to transmit the received light to the outside. A black mask member surrounds the portion of the outer lens. The portion of the outer lens that is disposed to receive the light has an inner surface at least a part of which is formed with an integrally formed surface texture. The surface texture is configured to diffusively transmit the light received from the light source.

Abstract: The present invention is a modularized private mesh networked streetlight pole, comprising: a base; a main body attached to the base; a lamp mounted on the main body and having an electrical connection; a first set of sensors affixed to an exterior of the main body and having electrical connections; and a second set of sensors affixed to an interior of the main body having electrical connections.

Abstract: A lid assembly for a sample tube, for collecting magnetic beads from the sample tube and subsequently releasing said beads, the lid assembly comprising: a closure part including means for removably attaching the closure part to the opening of the sample tube, to close the sample tube, and a bead-collecting platform arranged to locate within or above the opening of the sample tube when the closure part is attached to the sample tube, wherein the bead-collecting platform has a bead-collecting surface on one side, for coming into contact with liquid in the sample tube during use, and a magnet-receiving cavity on the other side, behind the bead-collecting surface; and a magnet-bearing part comprising a magnet, wherein the magnet is removably insertable into the magnet-receiving cavity, towards the bead-collecting surface, such that, when the magnet is present within the magnet-receiving cavity, the magnet is capable of holding magnetic beads against the bead-collecting surface, and when the magnet is not present

Abstract: A method performed by one or more computers for obtaining an optimized algorithm that (i) is functionally equivalent to a target algorithm and (ii) optimizes one or more target properties when executed on a target set of one or more hardware devices. The method includes: initializing a target tensor representing the target algorithm; generating, using a neural network having a plurality of network parameters, a tensor decomposition of the target tensor that parametrizes a candidate algorithm; generating target property values for each of the target properties when executing the candidate algorithm on the target set of hardware devices; determining a benchmarking score for the tensor decomposition based on the target property values of the candidate algorithm; generating a training example from the tensor decomposition and the benchmarking score; and storing, in a training data store, the training example for use in updating the network parameters of the neural network.

Abstract: The present invention is a system for providing power and controlling a plurality of ethernet devices as described. A driver, wherein the driver provides for the control of the system; a plurality of sensors, wherein the plurality of sensors collect sensor specific data and are in communication with the driver; a Power over Ethernet (POE) switch, wherein the POE switch is in communication with the plurality of sensors; a plurality of fixtures in communication with the driver and the POE switch, wherein the plurality of fixtures are light sources; and a local power source, wherein the local power source is in communication with the POE switch.

Abstract: The present invention is a system for providing power and controlling a plurality of components, comprising: a driver, wherein the driver provides for the control of the system and a gateway; a plurality of sensors, wherein the plurality of sensors collect sensor specific data and are in communication with the driver; a Power over Ethernet (POE) switch, wherein the POE switch is in communication with the plurality of sensors; and a plurality of devices in communication with the driver and the POE switch; wherein the plurality of devices and the plurality of sensors are routers for wireless connection between the plurality of sensors and the plurality of devices to the driver.

Abstract: The present invention is a Power over Ethernet (PoE) control module, comprising; an input connector adapted to receive a connection from a first cable, wherein the first cable provides a power signal and a command signal; an output connector adapted to receive a connection from a second cable, wherein the second cable sends a power signal to a set of light fixtures; a bridge circuitry connected to the input and output connectors, wherein the bridge circuitry separates the command signal from the power signal; and a microcontroller connected to the bridge circuity, wherein the microcontroller processes the command signal and sends the command signal to the set of light fixtures wirelessly.

Abstract: Disclosed herein is a computer-implemented method of identifying the presence of any of a plurality of prospective target nucleic acids in a solution containing a biological sample. The method comprises receiving amplification curve data indicative of an amplification reaction associated with at least one unknown nucleic acid present in the solution; processing the received data, wherein the processing comprises inputting input data into a machine learning model trained to identify any of the plurality of prospective target nucleic acids, wherein the input data is based on the amplification curve data and is indicative of the degree of amplification of the at least one unknown nucleic acid over time during the amplification reaction; and based on the processing, determining that the at least one unknown nucleic acid is one of the plurality of prospective nucleic acids, and thereby identifying the presence of at least one of the plurality of target nucleic acids in the solution.

Abstract: The present application relates to processor-implemented methods for determining a diagnostic outcome comprising receiving signals generated by an array of electro-chemical sensors in solution with a biological sample from a subject, each sensor of the array of electro-chemical sensors configured to generate a signal in response to one or more amplification reactions occurring in the solution, the one or more amplification reactions being indicative of the presence of an RNA host-response; processing the signals received from the array of electro-chemical sensors; based on the processing, assigning at least one value to the sample, the at least one value being indicative of a likelihood of the diagnostic outcome; based on the at least one assigned value, determining the diagnostic outcome.

Abstract: A method for enriching a map representation of a traffic infrastructure. The method includes: receiving map data of a map representation of a traffic infrastructure, the map representation including pieces of information of a multitude of roadways negotiable by vehicles, the map representation encompassing pieces of information regarding at least one roadway including a transition area; receiving trajectory data of a multitude of first driving trajectories and a multitude of second driving trajectories of a multitude of vehicles; ascertaining a first number of the first driving trajectories and a second number of the second driving trajectories, and comparing the first number to the second number; and marking the first route as a preferred route in the map representation if the first number is greater than the second number.

Abstract: A system for providing power and controlling a plurality of ethernet devices, a driver, wherein the driver provides for the control of the system; a plurality of sensors, wherein the plurality of sensors collect sensor specific data and are in communication with the driver; a Power over Ethernet (POE) switch, wherein the POE switch is in communication with the plurality of sensors; a plurality of fixtures in communication with the driver and the POE switch, wherein the plurality of fixtures are light sources; and a local power source, wherein the local power source is in communication with the POE switch.

Abstract: The present invention is a system for providing power and controlling a plurality of ethernet devices, comprising: a driver, wherein the driver provides for the control of the system; a plurality of sensors, wherein the plurality of sensors collect sensor specific data and are in communication with the driver; a Power over Ethernet (POE) switch, wherein the POE switch is in communication with the plurality of sensors; a plurality of fixtures in communication with the driver and the POE switch, wherein the plurality of fixtures are light sources; and a local power source, wherein the local power source is in communication with the POE switch.