Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures include: obtaining a design space for a modeled object and boundary conditions including a location where load is applied; checking whether, the boundary conditions include a specified direction for the load; assigning a direction for the load at the location when no specified direction is included; iteratively modifying a three dimensional shape in the design space in accordance with a physical response of the modeled object determined by a numerical simulation employing a linear analysis, where the iterative modification comprises determining a respective maximum sustainable load for each of two or more versions of the modified three dimensional shape; presenting to a user the two or more versions of the modeled object having different shapes; and receiving a user selection of one of the two or more versions of the modeled object.

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberucolosis complex, preferably a M. tuberculos clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP? phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM? phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberulosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.

Abstract: The present invention relates to a process for the manufacture of microporous carbon materials to perform selective separations of nitrogen in gas mixtures such as hydrogen sulfide, carbon dioxide, methane and C2, C3 and C4+ hydrocarbons, with high efficiency, shaped of microspheres or cylinders from copolymers of poly (vinylidene chloride-co-methyl acrylate) with density of 1.3 to 1.85 g/cm.sup.3 or poly (vinylidene chloride-co-vinyl chloride) with density of 1.3 to 1.85 g/cm.sup.3, using two stages. The first stage consists of a surface passivation of the material by chemical attack in a highly alkaline alcohol solution, with the aim of effecting a precarbonization on the surface of the copolymer that during the pyrolysis process is not deformed and gradually develops microporosity. The material of the first stage presents, in the layer, percentages between 55% to 85% carbon, between 5% to 20% oxygen, and between 10% to 40% chlorine.

Abstract: A conjugated diene copolymer has a covalent bond reversibly dissociated and added by heat, and has at least two peaks in each of curves of molecular weight distributions measured at 40° C. and 60° C. by gel permeation chromatography, wherein a change rate of the proportion of the area of the peak having the lowest molecular weight in measurement at 60° C. to the proportion of the area of the peak having the lowest molecular weight in measurement at 40° C.

Abstract: Aspects of the present disclosure provide systems, methods, and computer-readable storage media that support automated failure mode detection for rotating machinery based on vibration analysis. To illustrate, a computing device may receive vibration data from one or more sensors configured to measure vibrations of a rotating machine, such as an engine. The computing device may generate a frequency spectrum based on the vibration data (or receive the frequency spectrum) and compare the frequency spectrum to one or more predetermined frequency models to determine one or more similarity metrics. The one or more predetermined frequency models may each be associated with a respective failure mode of the rotating machine. The computing device may identify a failure mode associated with a predetermined frequency model that corresponds to a similarity metric that satisfies a threshold, and the computing device may output an indication of the identified failure mode.

Abstract: One embodiment of the present invention sets forth a technique for modeling assemblies using generative design techniques. The technique includes determining a portion of an assembly to model as a superelement and computing a mathematical model representing the superelement. The technique further includes eliminating one or more interior degrees of freedom from the mathematical model and computing a reduced stiffness matrix corresponding to the superelement by solving one or more equations associated with the mathematical model using an iterative sparse matrix solver.

Abstract: A music generation apparatus for generating information indicative of a musical score for a game, the apparatus including communication circuitry to communicate with an entertainment device, the communication circuitry being configured to receive a request to generate a musical score for a game, and to receive one or more keywords output by the entertainment device during processing of the game, the one or more keywords being indicative of one or more of an action and/or a condition associated with a user playing the game and the game state. The music generation apparatus also comprises music generation circuitry responsive to the request and each of the one or more keywords to generate the information indicative of the musical score in dependence on that keyword. An entertainment device is also provided, as well as a system, methods and computer programs.

Abstract: Disclosed herein are methods and systems for determining optimal primer sets for a multiplex assay, each of the optimal primer sets intended to amplify one or more targets. The method comprises obtaining amplification data from a plurality of preparatory assays. The amplification data describes at least the amplification of a first target of the one or more targets by a first primer set in a first preparatory assay, the amplification of the first target amplified by a second primer set in a second preparatory assay, the amplification of a second target of the one or more targets by the first primer set in a third preparatory assay, and the amplification of the second target by the second primer set in a fourth preparatory assay. The method further comprises determining a plurality of similarity metrics, each similarity metric being indicative of a degree of similarity between the amplification data produced by one of the plurality of preparatory assays compared to another one of the preparatory assays.

Abstract: A data processing apparatus includes storage circuitry to store animation data for a computer generated environment, the animation data specifying animations of animated objects of the computer generated environment for a period of time, selection circuitry to receive an animation data request and to select a portion of the animation data in dependence on the animation data request, and output circuitry to output the portion of the animation data.

Abstract: There is provided a data processing apparatus for generating one or more images of a virtual environment. The apparatus includes a rendering processor configured to render a first part of the one or more images; a communication processor configured to request, from a remote computing device, data for rendering a second part of the one or more images; and an output image processor configured to generate the one or more images for display at least in part based on the rendered first part of the one or more images and the data for rendering the second part of the one or more images.

Abstract: An on-board toilet cubicle for an aircraft, including a front long side and a rear long side; a front short side and a rear short side, which are each connected at one end to the front long side and at their other end to the rear long side, the long sides and the short sides enclosing an interior of the toilet cubicle, and the front and the rear long sides each being wider than the front and the rear short sides; a toilet unit with a toilet opening; and an L-shaped door for accessing the on-board toilet cubicle, the L-shaped door having one door leg in the front long side and one door leg in the front short side, the toilet unit arranged adjacent to the rear long side, and the door leg in the front long side being wider than the door leg in the front short side.

Abstract: A lighting assembly for a vehicle has a light source accommodated in a housing. The light source is configured to emit light. The lighting assembly has an outer lens coupled to the housing. At least a portion of the outer lens is positioned to receive light emitted from the light source and to transmit the received light to the outside. A black mask member surrounds the portion of the outer lens. The portion of the outer lens that is disposed to receive the light has an inner surface at least a part of which is formed with an integrally formed surface texture. The surface texture is configured to diffusively transmit the light received from the light source.

Abstract: The present invention is a modularized private mesh networked streetlight pole, comprising: a base; a main body attached to the base; a lamp mounted on the main body and having an electrical connection; a first set of sensors affixed to an exterior of the main body and having electrical connections; and a second set of sensors affixed to an interior of the main body having electrical connections.

Abstract: A method performed by one or more computers for obtaining an optimized algorithm that (i) is functionally equivalent to a target algorithm and (ii) optimizes one or more target properties when executed on a target set of one or more hardware devices. The method includes: initializing a target tensor representing the target algorithm; generating, using a neural network having a plurality of network parameters, a tensor decomposition of the target tensor that parametrizes a candidate algorithm; generating target property values for each of the target properties when executing the candidate algorithm on the target set of hardware devices; determining a benchmarking score for the tensor decomposition based on the target property values of the candidate algorithm; generating a training example from the tensor decomposition and the benchmarking score; and storing, in a training data store, the training example for use in updating the network parameters of the neural network.

Abstract: A lid assembly for a sample tube, for collecting magnetic beads from the sample tube and subsequently releasing said beads, the lid assembly comprising: a closure part including means for removably attaching the closure part to the opening of the sample tube, to close the sample tube, and a bead-collecting platform arranged to locate within or above the opening of the sample tube when the closure part is attached to the sample tube, wherein the bead-collecting platform has a bead-collecting surface on one side, for coming into contact with liquid in the sample tube during use, and a magnet-receiving cavity on the other side, behind the bead-collecting surface; and a magnet-bearing part comprising a magnet, wherein the magnet is removably insertable into the magnet-receiving cavity, towards the bead-collecting surface, such that, when the magnet is present within the magnet-receiving cavity, the magnet is capable of holding magnetic beads against the bead-collecting surface, and when the magnet is not present

Abstract: The present invention is a system for providing power and controlling a plurality of ethernet devices as described. A driver, wherein the driver provides for the control of the system; a plurality of sensors, wherein the plurality of sensors collect sensor specific data and are in communication with the driver; a Power over Ethernet (POE) switch, wherein the POE switch is in communication with the plurality of sensors; a plurality of fixtures in communication with the driver and the POE switch, wherein the plurality of fixtures are light sources; and a local power source, wherein the local power source is in communication with the POE switch.

Abstract: The present invention is a system for providing power and controlling a plurality of components, comprising: a driver, wherein the driver provides for the control of the system and a gateway; a plurality of sensors, wherein the plurality of sensors collect sensor specific data and are in communication with the driver; a Power over Ethernet (POE) switch, wherein the POE switch is in communication with the plurality of sensors; and a plurality of devices in communication with the driver and the POE switch; wherein the plurality of devices and the plurality of sensors are routers for wireless connection between the plurality of sensors and the plurality of devices to the driver.

Abstract: The present invention is a Power over Ethernet (PoE) control module, comprising; an input connector adapted to receive a connection from a first cable, wherein the first cable provides a power signal and a command signal; an output connector adapted to receive a connection from a second cable, wherein the second cable sends a power signal to a set of light fixtures; a bridge circuitry connected to the input and output connectors, wherein the bridge circuitry separates the command signal from the power signal; and a microcontroller connected to the bridge circuity, wherein the microcontroller processes the command signal and sends the command signal to the set of light fixtures wirelessly.

Abstract: The present application relates to processor-implemented methods for determining a diagnostic outcome comprising receiving signals generated by an array of electro-chemical sensors in solution with a biological sample from a subject, each sensor of the array of electro-chemical sensors configured to generate a signal in response to one or more amplification reactions occurring in the solution, the one or more amplification reactions being indicative of the presence of an RNA host-response; processing the signals received from the array of electro-chemical sensors; based on the processing, assigning at least one value to the sample, the at least one value being indicative of a likelihood of the diagnostic outcome; based on the at least one assigned value, determining the diagnostic outcome.

Abstract: Disclosed herein is a computer-implemented method of identifying the presence of any of a plurality of prospective target nucleic acids in a solution containing a biological sample. The method comprises receiving amplification curve data indicative of an amplification reaction associated with at least one unknown nucleic acid present in the solution; processing the received data, wherein the processing comprises inputting input data into a machine learning model trained to identify any of the plurality of prospective target nucleic acids, wherein the input data is based on the amplification curve data and is indicative of the degree of amplification of the at least one unknown nucleic acid over time during the amplification reaction; and based on the processing, determining that the at least one unknown nucleic acid is one of the plurality of prospective nucleic acids, and thereby identifying the presence of at least one of the plurality of target nucleic acids in the solution.