Patents by Inventor Jew Kwee Ngui
Jew Kwee Ngui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180311672Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: June 27, 2018Publication date: November 1, 2018Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 10010887Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: GrantFiled: October 10, 2014Date of Patent: July 3, 2018Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 9457351Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.Type: GrantFiled: March 12, 2014Date of Patent: October 4, 2016Assignee: Applied Biosystems, LLCInventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Wolfgang Heimberg
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Publication number: 20150024479Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: October 10, 2014Publication date: January 22, 2015Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 8859271Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: GrantFiled: February 16, 2011Date of Patent: October 14, 2014Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Publication number: 20140273182Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Wolfgang Heimberg
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Patent number: 8676383Abstract: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures.Type: GrantFiled: September 5, 2007Date of Patent: March 18, 2014Assignee: Applied Biosystems, LLCInventors: Lim Hi Tan, Jew Kwee Ngui, Hon Siu Shin, Ui Leng Soh, Yang Hooi Kee, Hock Lai Khoo, Mark T. Reed, Ching Ong Lau, Wolfgang Heimberg
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Publication number: 20110136219Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: February 16, 2011Publication date: June 9, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Hon Siu SHIN, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Publication number: 20090203120Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: April 9, 2009Publication date: August 13, 2009Applicant: Life Technologies CorporationInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 7169355Abstract: The invention includes a heating apparatus for biological samples. The heating apparatus of the present invention includes a cover, a sample block having a plurality of openings in a top portion thereof for receiving a sample well tray having a plurality of sample wells, and an urging mechanism. The urging mechanism is positionable between the sample block and the sample well tray to urge the sample well tray away from the sample block when the cover is moved from a closed position toward an open position. The cover imparts a downward force on the top of the sample well tray to press the sample wells into the openings of the sample block when the heated cover is moved toward a closed position. The urging mechanism imparts an upward force on the sample well tray. The downward force imparted by the heated cover is sufficient to retain the sample well tray against the sample block when the cover is in the closed position.Type: GrantFiled: February 2, 2000Date of Patent: January 30, 2007Assignee: Applera CorporationInventors: Hon Siu Shin, Jew Kwee Ngui, Adrian Fawcett, Kenneth P. Chao, Gary L. Bordenkircher, Jessica E. Barzilai, Donald R. Sandell
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Patent number: 6875604Abstract: A thermal cycling device for biological samples. The thermal cycling device may include a sample block, an annular plate, and a plurality of spring devices interposed between the sample block and the annular plate. The sample block has a plurality of openings for receiving sample wells of a sample well tray. The annular plate may be positioned adjacent the outer periphery of the sample block and may be configured to abut a bottom surface of the sample well tray when the sample well tray is positioned thereon. The plurality of spring device may be interposed between the sample block and the annular plate to urge the annular plate and sample well tray away from the sample block.Type: GrantFiled: August 14, 2003Date of Patent: April 5, 2005Assignee: Applera CorporationInventors: Hon Siu Shin, Jew Kwee Ngui
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Publication number: 20040241048Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: May 30, 2003Publication date: December 2, 2004Applicant: Applera CorporationInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Publication number: 20040033592Abstract: A thermal cycling device for biological samples. The thermal cycling device may include a sample block, an annular plate, and a plurality of spring devices interposed between the sample block and the annular plate. The sample block has a plurality of openings for receiving sample wells of a sample well tray. The annular plate may be positioned adjacent the outer periphery of the sample block and may be configured to abut a bottom surface of the sample well tray when the sample well tray is positioned thereon. The plurality of spring device may be interposed between the sample block and the annular plate to urge the annular plate and sample well tray away from the sample block.Type: ApplicationFiled: August 14, 2003Publication date: February 19, 2004Applicant: Applera CorporationInventors: Hon Siu Shin, Jew Kwee Ngui
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Patent number: 6638761Abstract: A thermal cycling device for biological samples. The thermal cycling device may include a sample block, an annular plate, and a plurality of spring devices interposed between the sample block and the annular plate. The sample block has a plurality of openings for receiving sample wells of a sample well tray. The annular plate may be positioned adjacent the outer periphery of the sample block and may be configured to abut a bottom surface of the sample well tray when the sample well tray is positioned thereon. The plurality of spring device may be interposed between the sample block and the annular plate to urge the annular plate and sample well tray away from the sample block.Type: GrantFiled: July 22, 2002Date of Patent: October 28, 2003Assignee: Applera CorporationInventors: Hon Siu Shin, Jew Kwee Ngui
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Publication number: 20030044969Abstract: A thermal cycling device for biological samples. The thermal cycling device may include a sample block, an annular plate, and a plurality of spring devices interposed between the sample block and the annular plate. The sample block has a plurality of openings for receiving sample wells of a sample well tray. The annular plate may be positioned adjacent the outer periphery of the sample block and may be configured to abut a bottom surface of the sample well tray when the sample well tray is positioned thereon. The plurality of spring device may be interposed between the sample block and the annular plate to urge the annular plate and sample well tray away from the sample block.Type: ApplicationFiled: July 22, 2002Publication date: March 6, 2003Inventors: Hon Siu Shin, Jew Kwee Ngui