Patents by Inventor Jeyaprakashnarayanan Seenisamy

Jeyaprakashnarayanan Seenisamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20230391790
    Abstract: Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: August 21, 2023
    Publication date: December 7, 2023
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Karthikeyan IYANAR
  • Indene derivatives useful in treating pain and inflammation
    Patent number: 11773108
    Abstract: Compounds of formula (1): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: October 3, 2023
    Assignee: Taro Pharmaceuticals Inc.
    Inventors: Curtis Harwig, Jeremy D. Pettigrew, Jennifer Cross, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Karthikeyan Iyanar
  • HEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20230203089
    Abstract: Wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: February 17, 2023
    Publication date: June 29, 2023
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER, Karthikeyan IYANAR
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20230002366
    Abstract: Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: August 4, 2022
    Publication date: January 5, 2023
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER
  • Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof
    Patent number: 11529350
    Abstract: Provided herein is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, R2, R3, R4, R5, R6, R7, R8, m, n) are as described herein. Compounds of Formula I, pharmaceutically acceptable salts thereof, pharmaceutical compositions of either of the foregoing, and combinations of any of the foregoing can be used to treat tyrosine kinase non-receptor 1 (TNK1)-mediated diseases, disorders and conditions.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: December 20, 2022
    Assignee: Sumitomo Pharma Oncology, Inc.
    Inventors: Adam Siddiqui-Jain, Jeyaprakashnarayanan Seenisamy, Steven L. Warner, Clifford J. Whatcott, David J. Bearss
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20220306645
    Abstract: Compounds of formula (1): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 29, 2022
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Karthikeyan IYANAR
  • Indene derivatives useful in treating pain and inflammation
    Patent number: 11420962
    Abstract: Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: August 23, 2022
    Assignee: TARO PHARMACEUTICALS INC.
    Inventors: Curtis Harwig, Jeremy D. Pettigrew, Jennifer Cross, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Samir Satish Kher
  • Process for manufacturing (S)-3-hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide
    Publication number: 20220251072
    Abstract: A process can be used for manufacturing (S)-3-hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide.
    Type: Application
    Filed: June 30, 2020
    Publication date: August 11, 2022
    Applicant: Merck Patent GmbH
    Inventors: Timo Heinrich, Jeyaprakashnarayanan Seenisamy
  • Indene derivatives useful in treating pain and inflammation
    Patent number: 11352367
    Abstract: Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: June 7, 2022
    Assignee: TARO PHARMACEUTICALS INC.
    Inventors: Curtis Harwig, Jeremy D. Pettigrew, Jennifer Cross, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Karthikeyan Iyanar
  • Heteroaryl compounds as BTK inhibitors and uses thereof
    Patent number: 11098041
    Abstract: Imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof are useful as BTK inhibitors.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: August 24, 2021
    Assignee: Merck Patent GmbH
    Inventors: Pascale Gaillard, Jeyaprakashnarayanan Seenisamy, Lesley Liu-Bujalski, Richard D. Caldwell, Justin Potnick, Hui Qiu, Constantin Neagu, Reinaldo Jones, Annie Cho Won, Andreas Goutopoulos, Brian A. Sherer, Theresa L. Johnson, Anna Gardberg
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20210155615
    Abstract: Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: April 5, 2019
    Publication date: May 27, 2021
    Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20210032264
    Abstract: Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: April 5, 2019
    Publication date: February 4, 2021
    Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Karthikeyan IYANAR
  • HEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20210024571
    Abstract: wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: April 5, 2019
    Publication date: January 28, 2021
    Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER, Karthikeyan IYANAR
  • Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitors and Uses Thereof
    Publication number: 20210000825
    Abstract: Provided herein is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X1, X2, R2, R3, R4, R5, R6, R7, R8, m, n) are as described herein. Compounds of Formula I, pharmaceutically acceptable salts thereof, pharmaceutical compositions of either of the foregoing, and combinations of any of the foregoing can be used to treat tyrosine kinase non-receptor 1 (TNK1)-mediated diseases, disorders and conditions.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 7, 2021
    Inventors: Adam Siddiqui-Jain, Jeyaprakashnarayanan Seenisamy, Steven L. Warner, Clifford J. Whatcott, David J. Bearss
  • HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20190233417
    Abstract: Imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof are useful as BTK inhibitors.
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Inventors: Pascale Gaillard, Jeyaprakashnarayanan Seenisamy, Lesley Liu-Bujalski, Richard D. Caldwell, Justin Potnick, Hui Qiu, Constantin Neagu, Reinaldo Jones, Annie Cho Won, Andreas Goutopoulos, Brian A. Sherer, Theresa L. Johnson, Anna Gardberg
  • Heteroaryl compounds as BTK inhibitors and uses thereof
    Patent number: 10253023
    Abstract: The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: April 9, 2019
    Assignee: Merck Patent GmbH
    Inventors: Pascale Gaillard, Jeyaprakashnarayanan Seenisamy, Lesley Liu-Bujalski, Richard D. Caldwell, Justin Potnick, Hui Qiu, Constantin Neagu, Reinaldo Jones, Annie Cho Won, Andreas Goutopoulos, Brian A. Sherer, Theresa L. Johnson, Anna Gardberg
  • Cyclic amides as MetAP-2 inhibitors
    Patent number: 10093623
    Abstract: Described are cyclic amide compounds of the formula (I): in which R1, R3, R5, R6, R7, R, X and Y have the meanings as described. The compounds are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 9, 2018
    Assignee: MERCK PATENT GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
  • Synthesis of a substituted indene derivative
    Patent number: 10053415
    Abstract: This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 21, 2018
    Assignee: Aquinox Pharmaceuticals (Canada) Inc.
    Inventors: Curtis Harwig, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Lakshindra Chetia
  • SYNTHESIS OF A SUBSTITUTED INDENE DERIVATIVE
    Publication number: 20180086691
    Abstract: This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
    Type: Application
    Filed: January 20, 2017
    Publication date: March 29, 2018
    Inventors: Curtis Harwig, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Lakshindra Chetia
  • SYNTHESIS OF A SUBSTITUTED INDENE DERIVATIVE
    Publication number: 20170204048
    Abstract: This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 20, 2017
    Inventors: Curtis Harwig, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Lakshindra Chetia