Abstract: The present invention relates to a multi-channel flat-tube serpentine heat exchanger and a heat exchange apparatus. The heat exchanger includes a flat pipe, a fin set and a divider assembly. The flat pipe has bending sections and connecting sections. The flat pipe is filled with a working fluid and has channels. The fin set is connected between the connecting sections to increase heat-exchange area of the flat pipe. The divider assembly is connected to the flat pipe to divide the flat pipe into a heat-absorbing region and a heat-releasing region. The working fluid in the heat-absorbing region absorbs heat to evaporate and then flows into the heat-releasing region along the channels. The evaporated working fluid condenses in the heat-releasing region to flow back to the heat-absorbing region along the channels by means of gravity. Therefore, the present invention has a reduced production cost and an increased heat-exchange efficiency.