Abstract: A method for determining a recurrence of a disease in a patient is presented. The method includes generating a plurality of medical images of an organ of the patient and determining a plurality of recurrence probabilities from the plurality of medical images. A recurrence of the disease is determined based on the plurality of recurrence probabilities and clinicopathological data of the patient using a Bayesian network.

Abstract: Various methods and systems are provided for an ultrasound-mediated therapy system. In one example, a method includes for one or more therapeutic ultrasound beams of a plurality of therapeutic ultrasound beams delivered to a therapy region of interest (ROI) via an ultrasound probe, identifying a respective location of the one or more therapeutic ultrasound beams relative to the therapy ROI based on: a respective modeled beam profile, a respective live two-dimensional (2D) image of the therapy ROI acquired with the ultrasound probe, a respective position of the ultrasound probe, and a known prior location of the therapy ROI, calculating a cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI based on the respective location of the one or more therapeutic ultrasound beams; and outputting an indication of the cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI for display on a display device.

Abstract: Systems and methods are provided for real-time multimodal deformable image registration for image-guided interventions. A pre-interventional three-dimensional (3D) magnetic resonance imaging (MRI) image and multiple 3D ultrasound (US) images capturing various respiratory states and poses are acquired for a patient. The MRI image is registered to each US image using a trained MR-US deformation model, producing deformed MRI images. During intervention, an interventional 3D US image is acquired and registered to a pre-interventional US image using a trained US-US deformation model, determining a warp field. This warp field is applied to the corresponding deformed MRI image, producing a registered 3D MRI image for visualizing annotated tissue features from the pre-interventional MRI on the live interventional US image.

Abstract: A computer-implemented method includes obtaining, via a processor, clinical images including vessels and generating, via the processor, straightened-out images for each coronary tree path within respective clinical images, The method also includes extracting, via the processor, segmented 3D image patches, determining, via the processor, overlapping binary mask volumes for each segment, and predicting, via the processor, pressure drops across the segmented image patches using a trained deep neural network.

Abstract: A computer-implemented method includes obtaining, via a processor, segmented image patches of a vessel along a coronary tree path and associated coronary flow distribution for respective vessel segments in the segmented image patches. The method also includes determining, via the processor, a pressure drop distribution along an axial length of the vessel from the segmented image patches and the associated coronary flow distribution. The method further includes determining, via the processor, critical points in the pressure drop distribution. The method even further includes detecting, via the processor, a presence of a stenosis based on the critical points in the pressure drop distribution.

Abstract: Various methods and systems are provided for an ultrasound-mediated therapy system. In one example, a method includes for one or more therapeutic ultrasound beams of a plurality of therapeutic ultrasound beams delivered to a therapy region of interest (ROI) via an ultrasound probe, identifying a respective location of the one or more therapeutic ultrasound beams relative to the therapy ROI based on: a respective modeled beam profile, a respective live two-dimensional (2D) image of the therapy ROI acquired with the ultrasound probe, a respective position of the ultrasound probe, and a known prior location of the therapy ROI, calculating a cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI based on the respective location of the one or more therapeutic ultrasound beams; and outputting an indication of the cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI for display on a display device.

Abstract: Various methods and systems are provided for an ultrasound-mediated therapy system. In one example, a method includes for one or more therapeutic ultrasound beams of a plurality of therapeutic ultrasound beams delivered to a therapy region of interest (ROI) of a patient via an ultrasound probe, identifying a respective location of the one or more therapeutic ultrasound beams relative to the therapy ROI of the patient based on one or more images of the therapy ROI acquired via the ultrasound probe; calculating a cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI based on the respective location of the one or more therapeutic ultrasound beams; and displaying a representation of the cumulative therapeutic ultrasound dose received at each sub-region of the therapy ROI on a display device.

Abstract: A computer-implemented method includes obtaining, via a processor, clinical images including vessels and generating, via the processor, straightened-out images for each coronary tree path within respective clinical images, The method also includes extracting, via the processor, segmented 3D image patches, determining, via the processor, overlapping binary mask volumes for each segment, and predicting, via the processor, pressure drops across the segmented image patches using a trained deep neural network.

Abstract: A computer-implemented method includes generating, via a processor, synthetic vessels. The method also includes performing, via the processor, three-dimensional (3D) computational fluid dynamics (CFD) on the synthetic vessels for different flow rates to generate 3D CFD data. The method further includes extracting, via the processor, 3D image patches from the synthetic vessels. The method even further includes obtaining, via the processor, pressure drops across the 3D image patches from the 3D CFD data. The method yet further includes training, via the processor, a deep neural network utilizing the 3D image patches, the pressure drops, and associated flow rates to generate a trained deep neural network.

Abstract: Systems and techniques that facilitate hybrid unsupervised and supervised image segmentation are provided. In various embodiments, a system can access a computed tomography (CT) image depicting an anatomical structure. In various aspects, the system can generate, via an unsupervised modeling technique, at least one class probability mask of the anatomical structure based on the CT image. In various instances, the system can generate, via a deep-learning model, an image segmentation based on the CT image and based on the at least one class probability mask.

Abstract: A method for determining a recurrence of a disease in a patient is presented. The method includes generating a plurality of medical images of an organ of the patient and determining a plurality of recurrence probabilities from the plurality of medical images. A recurrence of the disease is determined based on the plurality of recurrence probabilities and clinicopathological data of the patient using a Bayesian network.

Abstract: A method for determining a recurrence of a disease in a patient is presented. The method includes generating a plurality of medical images of an organ of the patient and determining a plurality of recurrence probabilities from the plurality of medical images. A recurrence of the disease is determined based on the plurality of recurrence probabilities and clinicopathological data of the patient using a Bayesian network.

Abstract: A computer-implemented method includes generating, via a processor, synthetic vessels. The method also includes performing, via the processor, three-dimensional (3D) computational fluid dynamics (CFD) on the synthetic vessels for different flow rates to generate 3D CFD data. The method further includes extracting, via the processor, 3D image patches from the synthetic vessels. The method even further includes obtaining, via the processor, pressure drops across the 3D image patches from the 3D CFD data. The method yet further includes training, via the processor, a deep neural network utilizing the 3D image patches, the pressure drops, and associated flow rates to generate a trained deep neural network.

Abstract: A computer-implemented method includes obtaining, via a processor, segmented image patches of a vessel along a coronary tree path and associated coronary flow distribution for respective vessel segments in the segmented image patches. The method also includes determining, via the processor, a pressure drop distribution along an axial length of the vessel from the segmented image patches and the associated coronary flow distribution. The method further includes determining, via the processor, critical points in the pressure drop distribution. The method even further includes detecting, via the processor, a presence of a stenosis based on the critical points in the pressure drop distribution.

Abstract: In accordance with the present disclosure, deep-learning techniques are employed to find anomalies corresponding to bleed events. By way of example, a deep convolutional neural network or combination of such networks may be trained to determine the location of a bleed event, such as an internal bleed event, based on ultrasound data acquired at one or more locations on a patient anatomy. Such a technique may be useful in non-clinical settings.

Abstract: Systems and techniques that facilitate hybrid unsupervised and supervised image segmentation are provided. In various embodiments, a system can access a computed tomography (CT) image depicting an anatomical structure. In various aspects, the system can generate, via an unsupervised modeling technique, at least one class probability mask of the anatomical structure based on the CT image. In various instances, the system can generate, via a deep-learning model, an image segmentation based on the CT image and based on the at least one class probability mask.

Abstract: The subject matter discussed herein relates to multi-modal image alignment to facilitate biopsy procedures and post-biopsy procedures. In one such example, prostate structures (or other suitable anatomic features or structures) are automatically segmented in pre-biopsy MR and pre-biopsy ultrasound images. Thereafter, pre-biopsy MR and pre-biopsy ultrasound contours are aligned. To account for non-linear deformation of the imaged anatomic structure, a patient-specific transformation model is trained via deep learning based at least in part on the pre-biopsy ultrasound images. The pre-biopsy ultrasound images that are overlaid with the pre-biopsy MR contours and based off the deformable transformation model are then aligned with the biopsy ultrasound images. Such real-time alignment using multi-modality imaging techniques provides guidance during the biopsy and post-biopsy system.

Abstract: The present disclosure relates to automatically determining respiratory phases (e.g., end-inspiration/expiration respiratory phases) in real time using ultrasound beamspace data. The respiratory phases may be used subsequently in a therapy or treatment (e.g., image-guided radiation-therapy (IGRT)) for precise dose-delivery. In certain implementations, vessel bifurcation may be tracked and respiration phases determined in real time using the tracked vessel bifurcations to facilitate respiration gating of the treatment or therapy.

Abstract: The subject matter discussed herein relates to the automatic, real-time registration of pre-operative magnetic resonance imaging (MRI) data to intra-operative ultrasound (US) data (e.g., reconstructed images or unreconstructed data), such as to facilitate surgical guidance or other interventional procedures. In one such example, brain structures (or other suitable anatomic features or structures) are automatically segmented in pre-operative and intra-operative ultrasound data. Thereafter, anatomic structure (e.g., brain structure) guided registration is applied between pre-operative and intra-operative ultrasound data to account for non-linear deformation of the imaged anatomic structure. MR images that are pre-registered to pre-operative ultrasound images are then given the same nonlinear spatial transformation to align the MR images with intra-operative ultrasound images to provide surgical guidance.

Abstract: The subject matter discussed herein relates to multi-modal image alignment to facilitate biopsy procedures and post-biopsy procedures. In one such example, prostate structures (or other suitable anatomic features or structures) are automatically segmented in pre-biopsy MR and pre-biopsy ultrasound images. Thereafter, pre-biopsy MR and pre-biopsy ultrasound contours are aligned. To account for non-linear deformation of the imaged anatomic structure, a patient-specific transformation model is trained via deep learning based at least in part on the pre-biopsy ultrasound images. The pre-biopsy ultrasound images that are overlaid with the pre-biopsy MR contours and based off the deformable transformation model are then aligned with the biopsy ultrasound images. Such real-time alignment using multi-modality imaging techniques provides guidance during the biopsy and post-biopsy system.